A side effect resource to capture phenotypic effects of drugs

Michael Kuhn; Monica Campillos; Ivica Letunic; Lars Juhl Jensen; Peer Bork

doi:10.1038/msb.2009.98

A side effect resource to capture phenotypic effects of drugs

Michael Kuhn, Monica Campillos, Ivica Letunic, Lars Juhl Jensen, Peer Bork

592 Citations (Scopus)

Abstract

The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.

Original language	English
Journal	Molecular Systems Biology
Volume	6
Pages (from-to)	343
ISSN	1744-4292
DOIs	https://doi.org/10.1038/msb.2009.98
Publication status	Published - 1 Jan 2010

Keywords

Adverse Drug Reaction Reporting Systems
Data Mining
Databases as Topic
Drug Therapy
Humans
Internet
Pharmaceutical Preparations
Phenotype
Risk Assessment
Structure-Activity Relationship

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/msb.2009.98

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title = "A side effect resource to capture phenotypic effects of drugs",

abstract = "The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.",

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T1 - A side effect resource to capture phenotypic effects of drugs

AU - Kuhn, Michael

AU - Campillos, Monica

AU - Letunic, Ivica

AU - Jensen, Lars Juhl

AU - Bork, Peer

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.

AB - The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.

KW - Adverse Drug Reaction Reporting Systems

KW - Data Mining

KW - Databases as Topic

KW - Drug Therapy

KW - Humans

KW - Internet

KW - Pharmaceutical Preparations

KW - Phenotype

KW - Risk Assessment

KW - Structure-Activity Relationship

U2 - 10.1038/msb.2009.98

DO - 10.1038/msb.2009.98

M3 - Journal article

C2 - 20087340

SN - 1744-4292

VL - 6

SP - 343

JO - Molecular Systems Biology

JF - Molecular Systems Biology

ER -

A side effect resource to capture phenotypic effects of drugs

Abstract

Keywords

UN SDGs

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