A side effect resource to capture phenotypic effects of drugs

TY - JOUR

T1 - A side effect resource to capture phenotypic effects of drugs

AU - Kuhn, Michael

AU - Campillos, Monica

AU - Letunic, Ivica

AU - Jensen, Lars Juhl

AU - Bork, Peer

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.

AB - The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.

KW - Adverse Drug Reaction Reporting Systems

KW - Data Mining

KW - Databases as Topic

KW - Drug Therapy

KW - Humans

KW - Internet

KW - Pharmaceutical Preparations

KW - Phenotype

KW - Risk Assessment

KW - Structure-Activity Relationship

U2 - 10.1038/msb.2009.98

DO - 10.1038/msb.2009.98

M3 - Journal article

C2 - 20087340

SN - 1744-4292

VL - 6

SP - 343

JO - Molecular Systems Biology

JF - Molecular Systems Biology

ER -