A role for the weak DnaA binding sites in bacterial replication origins

Godefroid Charbon; Anders Løbner-Olesen

doi:10.1111/j.1365-2958.2011.07840.x

A role for the weak DnaA binding sites in bacterial replication origins

6 Citations (Scopus)

Abstract

DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

Original language	English
Journal	Molecular Microbiology
Volume	82
Issue number	2
Pages (from-to)	272-274
Number of pages	3
ISSN	0950-382X
DOIs	https://doi.org/10.1111/j.1365-2958.2011.07840.x
Publication status	Published - Oct 2011
Externally published	Yes

Keywords

Bacterial Proteins/chemistry
Binding Sites
Caulobacter crescentus/chemistry
Chromosomes, Bacterial/genetics
DNA Replication
DNA-Binding Proteins/chemistry
Protein Binding
Replication Origin

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Cite this

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title = "A role for the weak DnaA binding sites in bacterial replication origins",

abstract = "DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.",

keywords = "Bacterial Proteins/chemistry, Binding Sites, Caulobacter crescentus/chemistry, Chromosomes, Bacterial/genetics, DNA Replication, DNA-Binding Proteins/chemistry, Protein Binding, Replication Origin",

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T1 - A role for the weak DnaA binding sites in bacterial replication origins

AU - Charbon, Godefroid

AU - Løbner-Olesen, Anders

PY - 2011/10

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N2 - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

AB - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

KW - Bacterial Proteins/chemistry

KW - Binding Sites

KW - Caulobacter crescentus/chemistry

KW - Chromosomes, Bacterial/genetics

KW - DNA Replication

KW - DNA-Binding Proteins/chemistry

KW - Protein Binding

KW - Replication Origin

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DO - 10.1111/j.1365-2958.2011.07840.x

M3 - Journal article

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SN - 0950-382X

VL - 82

SP - 272

EP - 274

JO - Molecular Microbiology

JF - Molecular Microbiology

IS - 2

ER -

A role for the weak DnaA binding sites in bacterial replication origins

Abstract

Keywords

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