A role for the weak DnaA binding sites in bacterial replication origins

Godefroid Charbon; Anders Løbner-Olesen

doi:10.1111/j.1365-2958.2011.07840.x

A role for the weak DnaA binding sites in bacterial replication origins

6 Citationer (Scopus)

Abstract

DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

Originalsprog	Engelsk
Tidsskrift	Molecular Microbiology
Vol/bind	82
Udgave nummer	2
Sider (fra-til)	272-274
Antal sider	3
ISSN	0950-382X
DOI	https://doi.org/10.1111/j.1365-2958.2011.07840.x
Status	Udgivet - okt. 2011
Udgivet eksternt	Ja

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10.1111/j.1365-2958.2011.07840.x

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Citationsformater

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abstract = "DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.",

keywords = "Bacterial Proteins/chemistry, Binding Sites, Caulobacter crescentus/chemistry, Chromosomes, Bacterial/genetics, DNA Replication, DNA-Binding Proteins/chemistry, Protein Binding, Replication Origin",

author = "Godefroid Charbon and Anders L{\o}bner-Olesen",

note = "{\textcopyright} 2011 Blackwell Publishing Ltd.",

year = "2011",

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doi = "10.1111/j.1365-2958.2011.07840.x",

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T1 - A role for the weak DnaA binding sites in bacterial replication origins

AU - Charbon, Godefroid

AU - Løbner-Olesen, Anders

PY - 2011/10

Y1 - 2011/10

N2 - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

AB - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

KW - Bacterial Proteins/chemistry

KW - Binding Sites

KW - Caulobacter crescentus/chemistry

KW - Chromosomes, Bacterial/genetics

KW - DNA Replication

KW - DNA-Binding Proteins/chemistry

KW - Protein Binding

KW - Replication Origin

U2 - 10.1111/j.1365-2958.2011.07840.x

DO - 10.1111/j.1365-2958.2011.07840.x

M3 - Journal article

C2 - 21958322

SN - 0950-382X

VL - 82

SP - 272

EP - 274

JO - Molecular Microbiology

JF - Molecular Microbiology

IS - 2

ER -

A role for the weak DnaA binding sites in bacterial replication origins

Abstract

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