A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control

P T Schmidt; E Näslund; P Grybäck; H Jacobsson; Jens Juul Holst; L Hilsted; P M Hellström

doi:10.1210/jc.2004-2089

A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control

P T Schmidt, E Näslund, P Grybäck, H Jacobsson, Jens Juul Holst, L Hilsted, P M Hellström

61 Citations (Scopus)

Abstract

CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.

OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.

DESIGN: This was a single-blind study.

SETTING: The study was performed at a university hospital.

PARTICIPANTS: Fourteen healthy adult subjects were studied.

INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).

MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).

RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.

CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	90
Issue number	9
Pages (from-to)	5241-6
Number of pages	6
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2004-2089
Publication status	Published - Sept 2005

Keywords

Adult
Appetite
Blood Glucose
Cross-Over Studies
Eating
Female
Food
Gastric Emptying
Glucagon
Hormones
Humans
Insulin
Male
Pain Measurement
Pancreatic Polypeptide
Postprandial Period
Reference Values
Satiation
Single-Blind Method
Water

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2004-2089

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@article{0920a22d3a0d434fa3327cf711697161,

title = "A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control",

abstract = "CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.DESIGN: This was a single-blind study.SETTING: The study was performed at a university hospital.PARTICIPANTS: Fourteen healthy adult subjects were studied.INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.",

keywords = "Adult, Appetite, Blood Glucose, Cross-Over Studies, Eating, Female, Food, Gastric Emptying, Glucagon, Hormones, Humans, Insulin, Male, Pain Measurement, Pancreatic Polypeptide, Postprandial Period, Reference Values, Satiation, Single-Blind Method, Water",

author = "Schmidt, {P T} and E N{\"a}slund and P Gryb{\"a}ck and H Jacobsson and Holst, {Jens Juul} and L Hilsted and Hellstr{\"o}m, {P M}",

year = "2005",

month = sep,

doi = "10.1210/jc.2004-2089",

language = "English",

volume = "90",

pages = "5241--6",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control

AU - Schmidt, P T

AU - Näslund, E

AU - Grybäck, P

AU - Jacobsson, H

AU - Holst, Jens Juul

AU - Hilsted, L

AU - Hellström, P M

PY - 2005/9

Y1 - 2005/9

N2 - CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.DESIGN: This was a single-blind study.SETTING: The study was performed at a university hospital.PARTICIPANTS: Fourteen healthy adult subjects were studied.INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.

AB - CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.DESIGN: This was a single-blind study.SETTING: The study was performed at a university hospital.PARTICIPANTS: Fourteen healthy adult subjects were studied.INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.

KW - Adult

KW - Appetite

KW - Blood Glucose

KW - Cross-Over Studies

KW - Eating

KW - Female

KW - Food

KW - Gastric Emptying

KW - Glucagon

KW - Hormones

KW - Humans

KW - Insulin

KW - Male

KW - Pain Measurement

KW - Pancreatic Polypeptide

KW - Postprandial Period

KW - Reference Values

KW - Satiation

KW - Single-Blind Method

KW - Water

U2 - 10.1210/jc.2004-2089

DO - 10.1210/jc.2004-2089

M3 - Journal article

C2 - 15998783

SN - 0021-972X

VL - 90

SP - 5241

EP - 5246

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 9

ER -

A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control

Abstract

Keywords

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