A role for both HLA-F and HLA-G in reproduction and during pregnancy?

TY - JOUR

T1 - A role for both HLA-F and HLA-G in reproduction and during pregnancy?

AU - Persson, Gry

AU - Jørgensen, Nanna

AU - Nilsson, Line Lynge

AU - Andersen, Lærke Heidam J.

AU - Hviid, Thomas Vauvert F.

PY - 2020/4

Y1 - 2020/4

N2 - The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases, in infertility and pregnancy complications, HLA-F has nearly been ignored. However, recent discoveries show that HLA-F can be expressed as both open conformers binding to a number of KIRs on primarily NK cells, as well as peptide-bound HLA-F binding to ILT2 and ILT4. Furthermore, a number of reports indicate a possible involvement of HLA-F in viral infections, in cancer immunology, and in fertility and reproduction, which may initiate more interest in this rather unknown HLA class I molecule. In this short review, we focus on recent discoveries that indicate a functional role for HLA-F in reproduction and during pregnancy, and the role of HLA-F in relation to HLA-G.

AB - The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases, in infertility and pregnancy complications, HLA-F has nearly been ignored. However, recent discoveries show that HLA-F can be expressed as both open conformers binding to a number of KIRs on primarily NK cells, as well as peptide-bound HLA-F binding to ILT2 and ILT4. Furthermore, a number of reports indicate a possible involvement of HLA-F in viral infections, in cancer immunology, and in fertility and reproduction, which may initiate more interest in this rather unknown HLA class I molecule. In this short review, we focus on recent discoveries that indicate a functional role for HLA-F in reproduction and during pregnancy, and the role of HLA-F in relation to HLA-G.

KW - HLA class Ib

KW - HLA-F

KW - HLA-G

KW - Pregnancy success

KW - Reproduction

U2 - 10.1016/j.humimm.2019.09.006

DO - 10.1016/j.humimm.2019.09.006

M3 - Review

C2 - 31558330

AN - SCOPUS:85072374748

SN - 0198-8859

JO - Human Immunology

JF - Human Immunology

ER -