A role for both HLA-F and HLA-G in reproduction and during pregnancy?

Gry Persson; Nanna Jørgensen; Line Lynge Nilsson; Lærke Heidam J. Andersen; Thomas Vauvert F. Hviid

doi:10.1016/j.humimm.2019.09.006

A role for both HLA-F and HLA-G in reproduction and during pregnancy?

Gry Persson, Nanna Jørgensen, Line Lynge Nilsson, Lærke Heidam J. Andersen, Thomas Vauvert F. Hviid^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases, in infertility and pregnancy complications, HLA-F has nearly been ignored. However, recent discoveries show that HLA-F can be expressed as both open conformers binding to a number of KIRs on primarily NK cells, as well as peptide-bound HLA-F binding to ILT2 and ILT4. Furthermore, a number of reports indicate a possible involvement of HLA-F in viral infections, in cancer immunology, and in fertility and reproduction, which may initiate more interest in this rather unknown HLA class I molecule. In this short review, we focus on recent discoveries that indicate a functional role for HLA-F in reproduction and during pregnancy, and the role of HLA-F in relation to HLA-G.

Originalsprog	Engelsk
Tidsskrift	Human Immunology
ISSN	0198-8859
DOI	https://doi.org/10.1016/j.humimm.2019.09.006
Status	Udgivet - apr. 2020

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Adgang til dokumentet

10.1016/j.humimm.2019.09.006

Citationsformater

@article{d577bd65b35f425095d8ffa15d073382,

title = "A role for both HLA-F and HLA-G in reproduction and during pregnancy?",

abstract = "The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases, in infertility and pregnancy complications, HLA-F has nearly been ignored. However, recent discoveries show that HLA-F can be expressed as both open conformers binding to a number of KIRs on primarily NK cells, as well as peptide-bound HLA-F binding to ILT2 and ILT4. Furthermore, a number of reports indicate a possible involvement of HLA-F in viral infections, in cancer immunology, and in fertility and reproduction, which may initiate more interest in this rather unknown HLA class I molecule. In this short review, we focus on recent discoveries that indicate a functional role for HLA-F in reproduction and during pregnancy, and the role of HLA-F in relation to HLA-G.",

keywords = "HLA class Ib, HLA-F, HLA-G, Pregnancy success, Reproduction",

author = "Gry Persson and Nanna J{\o}rgensen and Nilsson, {Line Lynge} and Andersen, {L{\ae}rke Heidam J.} and Hviid, {Thomas Vauvert F.}",

year = "2020",

month = apr,

doi = "10.1016/j.humimm.2019.09.006",

language = "English",

journal = "Human Immunology",