A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression

Joseph Diab; Rania Al-Mahdi; Sandra Gouveia-Figueira; Terkel Hansen; Einar Jensen; Rasmus Goll; Thomas Moritz; Jon Florholmen; Guro Forsdahl

doi:10.1093/ibd/izy349

A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression

Joseph Diab, Rania Al-Mahdi, Sandra Gouveia-Figueira, Terkel Hansen, Einar Jensen, Rasmus Goll, Thomas Moritz, Jon Florholmen, Guro Forsdahl

10 Citations (Scopus)

Abstract

The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (?-3 and ?-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to evaluate the potential link to cytokine gene expression during inflammatory events in ulcerative colitis (UC).

Original language	English
Journal	Inflammatory Bowel Diseases
Volume	25
Issue number	3
Pages (from-to)	490-497
Number of pages	8
ISSN	1078-0998
DOIs	https://doi.org/10.1093/ibd/izy349
Publication status	Published - 21 Feb 2019
Externally published	Yes

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Diab, J., Al-Mahdi, R., Gouveia-Figueira, S., Hansen, T., Jensen, E., Goll, R., Moritz, T., Florholmen, J., & Forsdahl, G. (2019). A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression. Inflammatory Bowel Diseases, 25(3), 490-497. https://doi.org/10.1093/ibd/izy349

A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression. / Diab, Joseph; Al-Mahdi, Rania; Gouveia-Figueira, Sandra et al.

In: Inflammatory Bowel Diseases, Vol. 25, No. 3, 21.02.2019, p. 490-497.

Research output: Contribution to journal › Journal article › Research › peer-review

Diab, J, Al-Mahdi, R, Gouveia-Figueira, S, Hansen, T, Jensen, E, Goll, R, Moritz, T, Florholmen, J & Forsdahl, G 2019, 'A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression', Inflammatory Bowel Diseases, vol. 25, no. 3, pp. 490-497. https://doi.org/10.1093/ibd/izy349

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A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression

Abstract

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