A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression

Joseph Diab; Rania Al-Mahdi; Sandra Gouveia-Figueira; Terkel Hansen; Einar Jensen; Rasmus Goll; Thomas Moritz; Jon Florholmen; Guro Forsdahl

doi:10.1093/ibd/izy349

A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression

Joseph Diab, Rania Al-Mahdi, Sandra Gouveia-Figueira, Terkel Hansen, Einar Jensen, Rasmus Goll, Thomas Moritz, Jon Florholmen, Guro Forsdahl

10 Citationer (Scopus)

Abstract

The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (?-3 and ?-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to evaluate the potential link to cytokine gene expression during inflammatory events in ulcerative colitis (UC).

Originalsprog	Engelsk
Tidsskrift	Inflammatory Bowel Diseases
Vol/bind	25
Udgave nummer	3
Sider (fra-til)	490-497
Antal sider	8
ISSN	1078-0998
DOI	https://doi.org/10.1093/ibd/izy349
Status	Udgivet - 21 feb. 2019
Udgivet eksternt	Ja

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10.1093/ibd/izy349

izy349.pdfForlagets udgivne version, 1 MBLicens: CC BY-NC

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Diab, J., Al-Mahdi, R., Gouveia-Figueira, S., Hansen, T., Jensen, E., Goll, R., Moritz, T., Florholmen, J., & Forsdahl, G. (2019). A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression. Inflammatory Bowel Diseases, 25(3), 490-497. https://doi.org/10.1093/ibd/izy349

A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression. / Diab, Joseph; Al-Mahdi, Rania; Gouveia-Figueira, Sandra et al.

I: Inflammatory Bowel Diseases, Bind 25, Nr. 3, 21.02.2019, s. 490-497.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Diab, J, Al-Mahdi, R, Gouveia-Figueira, S, Hansen, T, Jensen, E, Goll, R, Moritz, T, Florholmen, J & Forsdahl, G 2019, 'A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression', Inflammatory Bowel Diseases, bind 25, nr. 3, s. 490-497. https://doi.org/10.1093/ibd/izy349

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abstract = "The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (?-3 and ?-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to evaluate the potential link to cytokine gene expression during inflammatory events in ulcerative colitis (UC).",

author = "Joseph Diab and Rania Al-Mahdi and Sandra Gouveia-Figueira and Terkel Hansen and Einar Jensen and Rasmus Goll and Thomas Moritz and Jon Florholmen and Guro Forsdahl",

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AU - Al-Mahdi, Rania

AU - Gouveia-Figueira, Sandra

AU - Hansen, Terkel

AU - Jensen, Einar

AU - Goll, Rasmus

AU - Moritz, Thomas

AU - Florholmen, Jon

AU - Forsdahl, Guro

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AB - The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (?-3 and ?-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to evaluate the potential link to cytokine gene expression during inflammatory events in ulcerative colitis (UC).

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A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naive and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression

Abstract

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