A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

Maria E Due-Hansen; Sunil K Pandey; Elisabeth Christiansen; Rikke Andersen; Steffen V F Hansen; Trond Ulven

doi:10.1039/c5ob02129d

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

Maria E Due-Hansen, Sunil K Pandey, Elisabeth Christiansen, Rikke Andersen, Steffen V F Hansen, Trond Ulven

41 Citations (Scopus)

Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Original language	English
Journal	Organic & Biomolecular Chemistry
Volume	14
Issue number	2
Pages (from-to)	430-433
Number of pages	4
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c5ob02129d
Publication status	Published - 2016
Externally published	Yes

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c5ob02129dFinal published version, 302 KBLicence: CC BY

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title = "A protocol for amide bond formation with electron deficient amines and sterically hindered substrates",

abstract = "A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.",

author = "Due-Hansen, {Maria E} and Pandey, {Sunil K} and Elisabeth Christiansen and Rikke Andersen and Hansen, {Steffen V F} and Trond Ulven",

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AU - Pandey, Sunil K

AU - Christiansen, Elisabeth

AU - Andersen, Rikke

AU - Hansen, Steffen V F

AU - Ulven, Trond

PY - 2016

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AB - A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

U2 - 10.1039/c5ob02129d

DO - 10.1039/c5ob02129d

M3 - Journal article

SN - 1470-4358

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JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

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A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

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