Abstract
A porcine model of second intention wound healing was established and gross and histological changes needed for accurate assessing the age of wounds were determined. Twenty-five pigs were anesthetized before incision of four wounds on each. The wounds were left to heal from 1 h to 35 days when the pigs were euthanized. In 14 pigs, biopsies were sampled from two wounds between days 2 and 18. By histological evaluation the following characteristics were found useful for determining the age of wounds: neutrophil:macrophage ratio, angiogenesis, hyperplasia of fibroblasts, presence of hemosiderophages and granulation tissue. The latter was present from day 4 (n = 8 wounds, 100%), but by gross evaluation it was not recognized until day 5 (n = 4 wounds, 100%). From day 4 to 10, the thickness of granulation tissue increased by 1.2 ± 2.4 mm/day. The thickness of collagen fibers within granulation tissue increased throughout the study period, and complete epithelization was reached from day 18.
| Original language | English |
|---|---|
| Article number | 33 |
| Journal | Acta Veterinaria Scandinavica |
| Volume | 60 |
| Issue number | 1 |
| Number of pages | 7 |
| ISSN | 0044-605X |
| DOIs | |
| Publication status | Published - 2018 |
Keywords
- Age of wounds
- Experimental animal model
- Pig
- Skin
- Ulceration
- Veterinary forensic pathology