A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

Martin Nybo Andersen; Katarzyna Krzystanek; Frederic Petersen; Sofia Hammami Bomholtz; Søren-Peter Olesen; Hugues Abriel; Thomas Jespersen; Hanne Borger Rasmussen

doi:10.1074/jbc.M113.525931

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

Martin Nybo Andersen, Katarzyna Krzystanek, Frederic Petersen, Sofia Hammami Bomholtz, Søren-Peter Olesen, Hugues Abriel, Thomas Jespersen, Hanne Borger Rasmussen

20 Citationer (Scopus)

Abstract

Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.

Originalsprog	Engelsk
Tidsskrift	The Journal of Biological Chemistry
Vol/bind	288
Udgave nummer	52
Sider (fra-til)	36841-54
Antal sider	14
ISSN	0021-9258
DOI	https://doi.org/10.1074/jbc.M113.525931
Status	Udgivet - 27 dec. 2013

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10.1074/jbc.M113.525931

Citationsformater

Andersen, M. N., Krzystanek, K., Petersen, F., Bomholtz, S. H., Olesen, S-P., Abriel, H., Jespersen, T., & Rasmussen, H. B. (2013). A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. The Journal of Biological Chemistry, 288(52), 36841-54. https://doi.org/10.1074/jbc.M113.525931

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. / Andersen, Martin Nybo; Krzystanek, Katarzyna; Petersen, Frederic et al.

I: The Journal of Biological Chemistry, Bind 288, Nr. 52, 27.12.2013, s. 36841-54.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Andersen, MN, Krzystanek, K, Petersen, F, Bomholtz, SH, Olesen, S-P, Abriel, H, Jespersen, T & Rasmussen, HB 2013, 'A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein', The Journal of Biological Chemistry, bind 288, nr. 52, s. 36841-54. https://doi.org/10.1074/jbc.M113.525931

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title = "A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein",

abstract = "Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.",

author = "Andersen, {Martin Nybo} and Katarzyna Krzystanek and Frederic Petersen and Bomholtz, {Sofia Hammami} and S{\o}ren-Peter Olesen and Hugues Abriel and Thomas Jespersen and Rasmussen, {Hanne Borger}",

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doi = "10.1074/jbc.M113.525931",

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AU - Andersen, Martin Nybo

AU - Krzystanek, Katarzyna

AU - Petersen, Frederic

AU - Bomholtz, Sofia Hammami

AU - Olesen, Søren-Peter

AU - Abriel, Hugues

AU - Jespersen, Thomas

AU - Rasmussen, Hanne Borger

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.

AB - Background: PI3K regulates the surface expression of Kv7.1. Results: Kv7.1 surface expression depends on PI3K activity in polarized epithelial cells. SGK1 is the primary downstream target of PI3K in this process, which involves inhibition of Nedd4-2-dependent endocytosis of the channel. Conclusion: The surface expression of Kv7.1 is regulated by a PI3K-SGK1-Nedd4-2-mediated pathway. Significance: This pathway could regulate Kv7.1 cell surface expression levels in epithelial cells and cardiac myocytes.

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DO - 10.1074/jbc.M113.525931

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VL - 288

SP - 36841

EP - 36854

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 52

ER -

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

Abstract

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