A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Ruodan Xu; Stanislava Pankratova; Søren Hofman Oliveira Christiansen; David Paul Drucker Woldbye; Anne Højland; Elisabeth Marianne Bock; Vladimir Berezin

doi:10.1007/s11064-013-1166-1

A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Ruodan Xu, Stanislava Pankratova, Søren Hofman Oliveira Christiansen, David Paul Drucker Woldbye, Anne Højland, Elisabeth Marianne Bock, Vladimir Berezin

Eyepath Lab

2 Citations (Scopus)

Abstract

ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

Original language	English
Journal	Neurochemical Research
Volume	38
Issue number	12
Pages (from-to)	2550-8
Number of pages	9
ISSN	0364-3190
DOIs	https://doi.org/10.1007/s11064-013-1166-1
Publication status	Published - Dec 2013

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A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition. / Xu, Ruodan; Pankratova, Stanislava; Christiansen, Søren Hofman Oliveira et al.
In: Neurochemical Research, Vol. 38, No. 12, 12.2013, p. 2550-8.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.",

author = "Ruodan Xu and Stanislava Pankratova and Christiansen, {S{\o}ren Hofman Oliveira} and Woldbye, {David Paul Drucker} and Anne H{\o}jland and Bock, {Elisabeth Marianne} and Vladimir Berezin",

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AU - Xu, Ruodan

AU - Pankratova, Stanislava

AU - Christiansen, Søren Hofman Oliveira

AU - Woldbye, David Paul Drucker

AU - Højland, Anne

AU - Bock, Elisabeth Marianne

AU - Berezin, Vladimir

PY - 2013/12

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N2 - ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

AB - ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

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DO - 10.1007/s11064-013-1166-1

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ER -

A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Abstract

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