A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Ruodan Xu; Stanislava Pankratova; Søren Hofman Oliveira Christiansen; David Paul Drucker Woldbye; Anne Højland; Elisabeth Marianne Bock; Vladimir Berezin

doi:10.1007/s11064-013-1166-1

A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Ruodan Xu, Stanislava Pankratova, Søren Hofman Oliveira Christiansen, David Paul Drucker Woldbye, Anne Højland, Elisabeth Marianne Bock, Vladimir Berezin

Eyepath Lab

2 Citationer (Scopus)

Abstract

ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

Originalsprog	Engelsk
Tidsskrift	Neurochemical Research
Vol/bind	38
Udgave nummer	12
Sider (fra-til)	2550-8
Antal sider	9
ISSN	0364-3190
DOI	https://doi.org/10.1007/s11064-013-1166-1
Status	Udgivet - dec. 2013

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A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition. / Xu, Ruodan; Pankratova, Stanislava; Christiansen, Søren Hofman Oliveira et al.
I: Neurochemical Research, Bind 38, Nr. 12, 12.2013, s. 2550-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition",

abstract = "ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.",

author = "Ruodan Xu and Stanislava Pankratova and Christiansen, {S{\o}ren Hofman Oliveira} and Woldbye, {David Paul Drucker} and Anne H{\o}jland and Bock, {Elisabeth Marianne} and Vladimir Berezin",

year = "2013",

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doi = "10.1007/s11064-013-1166-1",

language = "English",

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T1 - A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

AU - Xu, Ruodan

AU - Pankratova, Stanislava

AU - Christiansen, Søren Hofman Oliveira

AU - Woldbye, David Paul Drucker

AU - Højland, Anne

AU - Bock, Elisabeth Marianne

AU - Berezin, Vladimir

PY - 2013/12

Y1 - 2013/12

N2 - ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

AB - ErbB receptors not only function in cancer, but are also key developmental regulators in the nervous system. We previously identified an ErbB1 peptide antagonist, Inherbin3, that is capable of inhibiting tumor growth in vitro and in vivo. In this study, we found that inhibition of ErbB1 kinase activity and activation of ErbB4 by NRG-1β induced neurite extension, suggesting that ErbB1 and ErbB4 act as negative and positive regulators, respectively, of the neuritogenic response. Inherbin3, inhibited activation not only of ErbB1 but also of ErbB4 in primary neurons, strongly induced neurite outgrowth in rat cerebellar granule neurons, indicating that this effect mainly was due to inhibition of ErbB1 activation.

U2 - 10.1007/s11064-013-1166-1

DO - 10.1007/s11064-013-1166-1

M3 - Journal article

C2 - 24132641

SN - 0364-3190

VL - 38

SP - 2550

EP - 2558

JO - Neurochemical Research

JF - Neurochemical Research

IS - 12

ER -

A Peptide Antagonist of ErbB Receptors, Inherbin3, Induces Neurite Outgrowth from Rat Cerebellar Granule Neurons Through ErbB1 Inhibition

Abstract

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