A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sven J. van der Lee; Olivia J. Conway; Iris Jansen; Minerva M. Carrasquillo; Luca Kleineidam; Erik van den Akker; Isabel Hernandez; Kristel R. van Eijk; Najada Stringa; Jason A. Chen; Anna Zettergren; Till F. M. Andlauer; Monica Diez-Fairen; Javier Simon-Sanchez; Alberto Lleo; Henrik Zetterberg; Marianne Nygaard; Cornelis Blauwendraat; Jeanne E. Savage; Jonas Mengel-From; Sonia Moreno-Grau; Michael Wagner; Juan Fortea; Michael J. Keogh; Kaj Blennow; Ingmar Skoog; Manuel A. Friese; Olga Pletnikova; Miren Zulaica; Carmen Lage; Itziar de Rojas; Steffi Riedel-Heller; Ignacio Illan-Gala; Wei Wei; Bernard Jeune; Adelina Orellana; Florian Then Bergh; Xue Wang; Marc Hulsman; Nina Beker; Niccolo Tesi; Christopher M. Morris; Begona Indakoetxea; Lyduine E. Collij; Martin Scherer; Estrella Morenas-Rodriguez; James W. Ironside; Bart N. M. van Berckel; Daniel Alcolea; Heinz Wiendl; Samantha L. Strickland; Pau Pastor; Eloy Rodriguez Rodriguez; Bradley F. Boeve; Ronald C. Petersen; Tanis J. Ferman; Jay A. van Gerpen; Marcel J. T. Reinders; Ryan J. Uitti; Lluis Tarraga; Wolfgang Maier; Oriol Dols-Icardo; Amit Kawalia; Maria Carolina Dalmasso; Merce Boada; Uwe K. Zettl; Natasja M. van Schoor; Marian Beekman; Mariet Allen; Eliezer Masliah; Adolfo Lopez de Munain; Alexander Pantelyat; Zbigniew K. Wszolek; Owen A. Ross; Dennis W. Dickson; Neill R. Graff-Radford; David Knopman; Rosa Rademakers; Afina W. Lemstra; Yolande A. L. Pijnenburg; Philip Scheltens; Thomas Gasser; Patrick F. Chinnery; Bernhard Hemmer; Martijn A. Huisman; Juan Troncoso; Fermin Moreno; Ellen A. Nohr; Thorkild I. A. Sørensen; Peter Heutink; Pascual Sanchez-Juan; Danielle Posthuma; Jordi Clarimon; Kaare Christensen; Nilufer Ertekin-Taner; Sonja W. Scholz; Alfredo Ramirez; Agustin Ruiz; Eline Slagboom; Wiesje M. van der Flier; Henne Holstege

doi:10.1007/s00401-019-02026-8

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernandez, Kristel R. van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleo, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-FromSonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J. Keogh, Kaj Blennow, Ingmar Skoog, Manuel A. Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illan-Gala, Wei Wei, Bernard Jeune, Adelina Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesi, Christopher M. Morris, Begona Indakoetxea, Lyduine E. Collij, Martin Scherer, Estrella Morenas-Rodriguez, James W. Ironside, Bart N. M. van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L. Strickland, Pau Pastor, Eloy Rodriguez Rodriguez, Bradley F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Jay A. van Gerpen, Marcel J. T. Reinders, Ryan J. Uitti, Lluis Tarraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Merce Boada, Uwe K. Zettl, Natasja M. van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo Lopez de Munain, Alexander Pantelyat, Zbigniew K. Wszolek, Owen A. Ross, Dennis W. Dickson, Neill R. Graff-Radford, David Knopman, Rosa Rademakers, Afina W. Lemstra, Yolande A. L. Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F. Chinnery, Bernhard Hemmer, Martijn A. Huisman, Juan Troncoso, Fermin Moreno, Ellen A. Nohr, Thorkild I. A. Sørensen, Peter Heutink, Pascual Sanchez-Juan, Danielle Posthuma, Jordi Clarimon, Kaare Christensen, Nilufer Ertekin-Taner, Sonja W. Scholz, Alfredo Ramirez, Agustin Ruiz, Eline Slagboom, Wiesje M. van der Flier, Henne Holstege

Department of Public Health

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Original language	English
Journal	Acta Neuropathologica
Volume	138
Issue number	2
Pages (from-to)	237-250
Number of pages	14
ISSN	0001-6322
DOIs	https://doi.org/10.1007/s00401-019-02026-8
Publication status	Published - 1 Aug 2019

Keywords

Alzheimer's disease
Frontotemporal dementia
Dementia with Lewy bodies
Progressive supranuclear palsy
Parkinson's disease
Amyotrophic lateral sclerosis
Multiple sclerosis
Neurodegenerative disease
Longevity
PLCG2
Phospholipase C Gamma 2

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10.1007/s00401-019-02026-8Licence: CC BY

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevityFinal published version, 1.16 MBLicence: CC BY

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van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernandez, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleo, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., ... Holstege, H. (2019). A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathologica, 138(2), 237-250. https://doi.org/10.1007/s00401-019-02026-8

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. / van der Lee, Sven J.; Conway, Olivia J.; Jansen, Iris et al.
In: Acta Neuropathologica, Vol. 138, No. 2, 01.08.2019, p. 237-250.

Research output: Contribution to journal › Journal article › Research › peer-review

van der Lee, SJ, Conway, OJ, Jansen, I, Carrasquillo, MM, Kleineidam, L, van den Akker, E, Hernandez, I, van Eijk, KR, Stringa, N, Chen, JA, Zettergren, A, Andlauer, TFM, Diez-Fairen, M, Simon-Sanchez, J, Lleo, A, Zetterberg, H, Nygaard, M, Blauwendraat, C, Savage, JE, Mengel-From, J, Moreno-Grau, S, Wagner, M, Fortea, J, Keogh, MJ, Blennow, K, Skoog, I, Friese, MA, Pletnikova, O, Zulaica, M, Lage, C, de Rojas, I, Riedel-Heller, S, Illan-Gala, I, Wei, W, Jeune, B, Orellana, A, Bergh, FT, Wang, X, Hulsman, M, Beker, N, Tesi, N, Morris, CM, Indakoetxea, B, Collij, LE, Scherer, M, Morenas-Rodriguez, E, Ironside, JW, van Berckel, BNM, Alcolea, D, Wiendl, H, Strickland, SL, Pastor, P, Rodriguez Rodriguez, E, Boeve, BF, Petersen, RC, Ferman, TJ, van Gerpen, JA, Reinders, MJT, Uitti, RJ, Tarraga, L, Maier, W, Dols-Icardo, O, Kawalia, A, Dalmasso, MC, Boada, M, Zettl, UK, van Schoor, NM, Beekman, M, Allen, M, Masliah, E, Lopez de Munain, A, Pantelyat, A, Wszolek, ZK, Ross, OA, Dickson, DW, Graff-Radford, NR, Knopman, D, Rademakers, R, Lemstra, AW, Pijnenburg, YAL, Scheltens, P, Gasser, T, Chinnery, PF, Hemmer, B, Huisman, MA, Troncoso, J, Moreno, F, Nohr, EA, Sørensen, TIA, Heutink, P, Sanchez-Juan, P, Posthuma, D, Clarimon, J, Christensen, K, Ertekin-Taner, N, Scholz, SW, Ramirez, A, Ruiz, A, Slagboom, E, van der Flier, WM & Holstege, H 2019, 'A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity', Acta Neuropathologica, vol. 138, no. 2, pp. 237-250. https://doi.org/10.1007/s00401-019-02026-8

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month = aug,

day = "1",

doi = "10.1007/s00401-019-02026-8",

language = "English",

volume = "138",

pages = "237--250",

journal = "Acta Neuropathologica",

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T1 - A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

AU - van der Lee, Sven J.

AU - Conway, Olivia J.

AU - Jansen, Iris

AU - Carrasquillo, Minerva M.

AU - Kleineidam, Luca

AU - van den Akker, Erik

AU - Hernandez, Isabel

AU - van Eijk, Kristel R.

AU - Stringa, Najada

AU - Chen, Jason A.

AU - Zettergren, Anna

AU - Andlauer, Till F. M.

AU - Diez-Fairen, Monica

AU - Simon-Sanchez, Javier

AU - Lleo, Alberto

AU - Zetterberg, Henrik

AU - Nygaard, Marianne

AU - Blauwendraat, Cornelis

AU - Savage, Jeanne E.

AU - Mengel-From, Jonas

AU - Moreno-Grau, Sonia

AU - Wagner, Michael

AU - Fortea, Juan

AU - Keogh, Michael J.

AU - Blennow, Kaj

AU - Skoog, Ingmar

AU - Friese, Manuel A.

AU - Pletnikova, Olga

AU - Zulaica, Miren

AU - Lage, Carmen

AU - de Rojas, Itziar

AU - Riedel-Heller, Steffi

AU - Illan-Gala, Ignacio

AU - Wei, Wei

AU - Jeune, Bernard

AU - Orellana, Adelina

AU - Bergh, Florian Then

AU - Wang, Xue

AU - Hulsman, Marc

AU - Beker, Nina

AU - Tesi, Niccolo

AU - Morris, Christopher M.

AU - Indakoetxea, Begona

AU - Collij, Lyduine E.

AU - Scherer, Martin

AU - Morenas-Rodriguez, Estrella

AU - Ironside, James W.

AU - van Berckel, Bart N. M.

AU - Alcolea, Daniel

AU - Wiendl, Heinz

AU - Strickland, Samantha L.

AU - Pastor, Pau

AU - Rodriguez Rodriguez, Eloy

AU - Boeve, Bradley F.

AU - Petersen, Ronald C.

AU - Ferman, Tanis J.

AU - van Gerpen, Jay A.

AU - Reinders, Marcel J. T.

AU - Uitti, Ryan J.

AU - Tarraga, Lluis

AU - Maier, Wolfgang

AU - Dols-Icardo, Oriol

AU - Kawalia, Amit

AU - Dalmasso, Maria Carolina

AU - Boada, Merce

AU - Zettl, Uwe K.

AU - van Schoor, Natasja M.

AU - Beekman, Marian

AU - Allen, Mariet

AU - Masliah, Eliezer

AU - Lopez de Munain, Adolfo

AU - Pantelyat, Alexander

AU - Wszolek, Zbigniew K.

AU - Ross, Owen A.

AU - Dickson, Dennis W.

AU - Graff-Radford, Neill R.

AU - Knopman, David

AU - Rademakers, Rosa

AU - Lemstra, Afina W.

AU - Pijnenburg, Yolande A. L.

AU - Scheltens, Philip

AU - Gasser, Thomas

AU - Chinnery, Patrick F.

AU - Hemmer, Bernhard

AU - Huisman, Martijn A.

AU - Troncoso, Juan

AU - Moreno, Fermin

AU - Nohr, Ellen A.

AU - Sørensen, Thorkild I. A.

AU - Heutink, Peter

AU - Sanchez-Juan, Pascual

AU - Posthuma, Danielle

AU - Clarimon, Jordi

AU - Christensen, Kaare

AU - Ertekin-Taner, Nilufer

AU - Scholz, Sonja W.

AU - Ramirez, Alfredo

AU - Ruiz, Agustin

AU - Slagboom, Eline

AU - van der Flier, Wiesje M.

AU - Holstege, Henne

PY - 2019/8/1

Y1 - 2019/8/1

KW - Alzheimer's disease

KW - Frontotemporal dementia

KW - Dementia with Lewy bodies

KW - Progressive supranuclear palsy

KW - Parkinson's disease

KW - Amyotrophic lateral sclerosis

KW - Multiple sclerosis

KW - Neurodegenerative disease

KW - Longevity

KW - PLCG2

KW - Phospholipase C Gamma 2

U2 - 10.1007/s00401-019-02026-8

DO - 10.1007/s00401-019-02026-8

M3 - Journal article

C2 - 31131421

SN - 0001-6322

VL - 138

SP - 237

EP - 250

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 2

ER -

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Keywords

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