A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sven J. van der Lee; Olivia J. Conway; Iris Jansen; Minerva M. Carrasquillo; Luca Kleineidam; Erik van den Akker; Isabel Hernandez; Kristel R. van Eijk; Najada Stringa; Jason A. Chen; Anna Zettergren; Till F. M. Andlauer; Monica Diez-Fairen; Javier Simon-Sanchez; Alberto Lleo; Henrik Zetterberg; Marianne Nygaard; Cornelis Blauwendraat; Jeanne E. Savage; Jonas Mengel-From; Sonia Moreno-Grau; Michael Wagner; Juan Fortea; Michael J. Keogh; Kaj Blennow; Ingmar Skoog; Manuel A. Friese; Olga Pletnikova; Miren Zulaica; Carmen Lage; Itziar de Rojas; Steffi Riedel-Heller; Ignacio Illan-Gala; Wei Wei; Bernard Jeune; Adelina Orellana; Florian Then Bergh; Xue Wang; Marc Hulsman; Nina Beker; Niccolo Tesi; Christopher M. Morris; Begona Indakoetxea; Lyduine E. Collij; Martin Scherer; Estrella Morenas-Rodriguez; James W. Ironside; Bart N. M. van Berckel; Daniel Alcolea; Heinz Wiendl; Samantha L. Strickland; Pau Pastor; Eloy Rodriguez Rodriguez; Bradley F. Boeve; Ronald C. Petersen; Tanis J. Ferman; Jay A. van Gerpen; Marcel J. T. Reinders; Ryan J. Uitti; Lluis Tarraga; Wolfgang Maier; Oriol Dols-Icardo; Amit Kawalia; Maria Carolina Dalmasso; Merce Boada; Uwe K. Zettl; Natasja M. van Schoor; Marian Beekman; Mariet Allen; Eliezer Masliah; Adolfo Lopez de Munain; Alexander Pantelyat; Zbigniew K. Wszolek; Owen A. Ross; Dennis W. Dickson; Neill R. Graff-Radford; David Knopman; Rosa Rademakers; Afina W. Lemstra; Yolande A. L. Pijnenburg; Philip Scheltens; Thomas Gasser; Patrick F. Chinnery; Bernhard Hemmer; Martijn A. Huisman; Juan Troncoso; Fermin Moreno; Ellen A. Nohr; Thorkild I. A. Sørensen; Peter Heutink; Pascual Sanchez-Juan; Danielle Posthuma; Jordi Clarimon; Kaare Christensen; Nilufer Ertekin-Taner; Sonja W. Scholz; Alfredo Ramirez; Agustin Ruiz; Eline Slagboom; Wiesje M. van der Flier; Henne Holstege

doi:10.1007/s00401-019-02026-8

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sven J. van der Lee, Olivia J. Conway, Iris Jansen, Minerva M. Carrasquillo, Luca Kleineidam, Erik van den Akker, Isabel Hernandez, Kristel R. van Eijk, Najada Stringa, Jason A. Chen, Anna Zettergren, Till F. M. Andlauer, Monica Diez-Fairen, Javier Simon-Sanchez, Alberto Lleo, Henrik Zetterberg, Marianne Nygaard, Cornelis Blauwendraat, Jeanne E. Savage, Jonas Mengel-FromSonia Moreno-Grau, Michael Wagner, Juan Fortea, Michael J. Keogh, Kaj Blennow, Ingmar Skoog, Manuel A. Friese, Olga Pletnikova, Miren Zulaica, Carmen Lage, Itziar de Rojas, Steffi Riedel-Heller, Ignacio Illan-Gala, Wei Wei, Bernard Jeune, Adelina Orellana, Florian Then Bergh, Xue Wang, Marc Hulsman, Nina Beker, Niccolo Tesi, Christopher M. Morris, Begona Indakoetxea, Lyduine E. Collij, Martin Scherer, Estrella Morenas-Rodriguez, James W. Ironside, Bart N. M. van Berckel, Daniel Alcolea, Heinz Wiendl, Samantha L. Strickland, Pau Pastor, Eloy Rodriguez Rodriguez, Bradley F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Jay A. van Gerpen, Marcel J. T. Reinders, Ryan J. Uitti, Lluis Tarraga, Wolfgang Maier, Oriol Dols-Icardo, Amit Kawalia, Maria Carolina Dalmasso, Merce Boada, Uwe K. Zettl, Natasja M. van Schoor, Marian Beekman, Mariet Allen, Eliezer Masliah, Adolfo Lopez de Munain, Alexander Pantelyat, Zbigniew K. Wszolek, Owen A. Ross, Dennis W. Dickson, Neill R. Graff-Radford, David Knopman, Rosa Rademakers, Afina W. Lemstra, Yolande A. L. Pijnenburg, Philip Scheltens, Thomas Gasser, Patrick F. Chinnery, Bernhard Hemmer, Martijn A. Huisman, Juan Troncoso, Fermin Moreno, Ellen A. Nohr, Thorkild I. A. Sørensen, Peter Heutink, Pascual Sanchez-Juan, Danielle Posthuma, Jordi Clarimon, Kaare Christensen, Nilufer Ertekin-Taner, Sonja W. Scholz, Alfredo Ramirez, Agustin Ruiz, Eline Slagboom, Wiesje M. van der Flier, Henne Holstege

Institut for Folkesundhedsvidenskab

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Originalsprog	Engelsk
Tidsskrift	Acta Neuropathologica
Vol/bind	138
Udgave nummer	2
Sider (fra-til)	237-250
Antal sider	14
ISSN	0001-6322
DOI	https://doi.org/10.1007/s00401-019-02026-8
Status	Udgivet - 1 aug. 2019

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10.1007/s00401-019-02026-8Licens: CC BY

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevityForlagets udgivne version, 1,16 MBLicens: CC BY

Citationsformater

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernandez, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleo, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., ... Holstege, H. (2019). A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathologica, 138(2), 237-250. https://doi.org/10.1007/s00401-019-02026-8

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. / van der Lee, Sven J.; Conway, Olivia J.; Jansen, Iris et al.
I: Acta Neuropathologica, Bind 138, Nr. 2, 01.08.2019, s. 237-250.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

van der Lee, SJ, Conway, OJ, Jansen, I, Carrasquillo, MM, Kleineidam, L, van den Akker, E, Hernandez, I, van Eijk, KR, Stringa, N, Chen, JA, Zettergren, A, Andlauer, TFM, Diez-Fairen, M, Simon-Sanchez, J, Lleo, A, Zetterberg, H, Nygaard, M, Blauwendraat, C, Savage, JE, Mengel-From, J, Moreno-Grau, S, Wagner, M, Fortea, J, Keogh, MJ, Blennow, K, Skoog, I, Friese, MA, Pletnikova, O, Zulaica, M, Lage, C, de Rojas, I, Riedel-Heller, S, Illan-Gala, I, Wei, W, Jeune, B, Orellana, A, Bergh, FT, Wang, X, Hulsman, M, Beker, N, Tesi, N, Morris, CM, Indakoetxea, B, Collij, LE, Scherer, M, Morenas-Rodriguez, E, Ironside, JW, van Berckel, BNM, Alcolea, D, Wiendl, H, Strickland, SL, Pastor, P, Rodriguez Rodriguez, E, Boeve, BF, Petersen, RC, Ferman, TJ, van Gerpen, JA, Reinders, MJT, Uitti, RJ, Tarraga, L, Maier, W, Dols-Icardo, O, Kawalia, A, Dalmasso, MC, Boada, M, Zettl, UK, van Schoor, NM, Beekman, M, Allen, M, Masliah, E, Lopez de Munain, A, Pantelyat, A, Wszolek, ZK, Ross, OA, Dickson, DW, Graff-Radford, NR, Knopman, D, Rademakers, R, Lemstra, AW, Pijnenburg, YAL, Scheltens, P, Gasser, T, Chinnery, PF, Hemmer, B, Huisman, MA, Troncoso, J, Moreno, F, Nohr, EA, Sørensen, TIA, Heutink, P, Sanchez-Juan, P, Posthuma, D, Clarimon, J, Christensen, K, Ertekin-Taner, N, Scholz, SW, Ramirez, A, Ruiz, A, Slagboom, E, van der Flier, WM & Holstege, H 2019, 'A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity', Acta Neuropathologica, bind 138, nr. 2, s. 237-250. https://doi.org/10.1007/s00401-019-02026-8

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title = "A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity",

keywords = "Alzheimer's disease, Frontotemporal dementia, Dementia with Lewy bodies, Progressive supranuclear palsy, Parkinson's disease, Amyotrophic lateral sclerosis, Multiple sclerosis, Neurodegenerative disease, Longevity, PLCG2, Phospholipase C Gamma 2",

author = "{van der Lee}, {Sven J.} and Conway, {Olivia J.} and Iris Jansen and Carrasquillo, {Minerva M.} and Luca Kleineidam and {van den Akker}, Erik and Isabel Hernandez and {van Eijk}, {Kristel R.} and Najada Stringa and Chen, {Jason A.} and Anna Zettergren and Andlauer, {Till F. M.} and Monica Diez-Fairen and Javier Simon-Sanchez and Alberto Lleo and Henrik Zetterberg and Marianne Nygaard and Cornelis Blauwendraat and Savage, {Jeanne E.} and Jonas Mengel-From and Sonia Moreno-Grau and Michael Wagner and Juan Fortea and Keogh, {Michael J.} and Kaj Blennow and Ingmar Skoog and Friese, {Manuel A.} and Olga Pletnikova and Miren Zulaica and Carmen Lage and {de Rojas}, Itziar and Steffi Riedel-Heller and Ignacio Illan-Gala and Wei Wei and Bernard Jeune and Adelina Orellana and Bergh, {Florian Then} and Xue Wang and Marc Hulsman and Nina Beker and Niccolo Tesi and Morris, {Christopher M.} and Begona Indakoetxea and Collij, {Lyduine E.} and Martin Scherer and Estrella Morenas-Rodriguez and Ironside, {James W.} and {van Berckel}, {Bart N. M.} and Daniel Alcolea and Heinz Wiendl and Strickland, {Samantha L.} and Pau Pastor and {Rodriguez Rodriguez}, Eloy and Boeve, {Bradley F.} and Petersen, {Ronald C.} and Ferman, {Tanis J.} and {van Gerpen}, {Jay A.} and Reinders, {Marcel J. T.} and Uitti, {Ryan J.} and Lluis Tarraga and Wolfgang Maier and Oriol Dols-Icardo and Amit Kawalia and Dalmasso, {Maria Carolina} and Merce Boada and Zettl, {Uwe K.} and {van Schoor}, {Natasja M.} and Marian Beekman and Mariet Allen and Eliezer Masliah and {Lopez de Munain}, Adolfo and Alexander Pantelyat and Wszolek, {Zbigniew K.} and Ross, {Owen A.} and Dickson, {Dennis W.} and Graff-Radford, {Neill R.} and David Knopman and Rosa Rademakers and Lemstra, {Afina W.} and Pijnenburg, {Yolande A. L.} and Philip Scheltens and Thomas Gasser and Chinnery, {Patrick F.} and Bernhard Hemmer and Huisman, {Martijn A.} and Juan Troncoso and Fermin Moreno and Nohr, {Ellen A.} and S{\o}rensen, {Thorkild I. A.} and Peter Heutink and Pascual Sanchez-Juan and Danielle Posthuma and Jordi Clarimon and Kaare Christensen and Nilufer Ertekin-Taner and Scholz, {Sonja W.} and Alfredo Ramirez and Agustin Ruiz and Eline Slagboom and {van der Flier}, {Wiesje M.} and Henne Holstege",

year = "2019",

month = aug,

day = "1",

doi = "10.1007/s00401-019-02026-8",

language = "English",

volume = "138",

pages = "237--250",

journal = "Acta Neuropathologica",

issn = "0001-6322",

publisher = "Springer",

number = "2",

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TY - JOUR

T1 - A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

AU - van der Lee, Sven J.

AU - Conway, Olivia J.

AU - Jansen, Iris

AU - Carrasquillo, Minerva M.

AU - Kleineidam, Luca

AU - van den Akker, Erik

AU - Hernandez, Isabel

AU - van Eijk, Kristel R.

AU - Stringa, Najada

AU - Chen, Jason A.

AU - Zettergren, Anna

AU - Andlauer, Till F. M.

AU - Diez-Fairen, Monica

AU - Simon-Sanchez, Javier

AU - Lleo, Alberto

AU - Zetterberg, Henrik

AU - Nygaard, Marianne

AU - Blauwendraat, Cornelis

AU - Savage, Jeanne E.

AU - Mengel-From, Jonas

AU - Moreno-Grau, Sonia

AU - Wagner, Michael

AU - Fortea, Juan

AU - Keogh, Michael J.

AU - Blennow, Kaj

AU - Skoog, Ingmar

AU - Friese, Manuel A.

AU - Pletnikova, Olga

AU - Zulaica, Miren

AU - Lage, Carmen

AU - de Rojas, Itziar

AU - Riedel-Heller, Steffi

AU - Illan-Gala, Ignacio

AU - Wei, Wei

AU - Jeune, Bernard

AU - Orellana, Adelina

AU - Bergh, Florian Then

AU - Wang, Xue

AU - Hulsman, Marc

AU - Beker, Nina

AU - Tesi, Niccolo

AU - Morris, Christopher M.

AU - Indakoetxea, Begona

AU - Collij, Lyduine E.

AU - Scherer, Martin

AU - Morenas-Rodriguez, Estrella

AU - Ironside, James W.

AU - van Berckel, Bart N. M.

AU - Alcolea, Daniel

AU - Wiendl, Heinz

AU - Strickland, Samantha L.

AU - Pastor, Pau

AU - Rodriguez Rodriguez, Eloy

AU - Boeve, Bradley F.

AU - Petersen, Ronald C.

AU - Ferman, Tanis J.

AU - van Gerpen, Jay A.

AU - Reinders, Marcel J. T.

AU - Uitti, Ryan J.

AU - Tarraga, Lluis

AU - Maier, Wolfgang

AU - Dols-Icardo, Oriol

AU - Kawalia, Amit

AU - Dalmasso, Maria Carolina

AU - Boada, Merce

AU - Zettl, Uwe K.

AU - van Schoor, Natasja M.

AU - Beekman, Marian

AU - Allen, Mariet

AU - Masliah, Eliezer

AU - Lopez de Munain, Adolfo

AU - Pantelyat, Alexander

AU - Wszolek, Zbigniew K.

AU - Ross, Owen A.

AU - Dickson, Dennis W.

AU - Graff-Radford, Neill R.

AU - Knopman, David

AU - Rademakers, Rosa

AU - Lemstra, Afina W.

AU - Pijnenburg, Yolande A. L.

AU - Scheltens, Philip

AU - Gasser, Thomas

AU - Chinnery, Patrick F.

AU - Hemmer, Bernhard

AU - Huisman, Martijn A.

AU - Troncoso, Juan

AU - Moreno, Fermin

AU - Nohr, Ellen A.

AU - Sørensen, Thorkild I. A.

AU - Heutink, Peter

AU - Sanchez-Juan, Pascual

AU - Posthuma, Danielle

AU - Clarimon, Jordi

AU - Christensen, Kaare

AU - Ertekin-Taner, Nilufer

AU - Scholz, Sonja W.

AU - Ramirez, Alfredo

AU - Ruiz, Agustin

AU - Slagboom, Eline

AU - van der Flier, Wiesje M.

AU - Holstege, Henne

PY - 2019/8/1

Y1 - 2019/8/1

KW - Alzheimer's disease

KW - Frontotemporal dementia

KW - Dementia with Lewy bodies

KW - Progressive supranuclear palsy

KW - Parkinson's disease

KW - Amyotrophic lateral sclerosis

KW - Multiple sclerosis

KW - Neurodegenerative disease

KW - Longevity

KW - PLCG2

KW - Phospholipase C Gamma 2

U2 - 10.1007/s00401-019-02026-8

DO - 10.1007/s00401-019-02026-8

M3 - Journal article

C2 - 31131421

SN - 0001-6322

VL - 138

SP - 237

EP - 250

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 2

ER -

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

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