Abstract
A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.
| Original language | English |
|---|---|
| Journal | Organic Letters |
| Volume | 11 |
| Issue number | 22 |
| Pages (from-to) | 5134-5137 |
| Number of pages | 4 |
| ISSN | 1523-7060 |
| DOIs | |
| Publication status | Published - 19 Nov 2009 |