A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Trine P Petersen; Andreas Ritzén; Trond Ulven

doi:10.1021/ol902101c

A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Trine P Petersen, Andreas Ritzén, Trond Ulven

41 Citationer (Scopus)

Abstract

A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.

Originalsprog	Engelsk
Tidsskrift	Organic Letters
Vol/bind	11
Udgave nummer	22
Sider (fra-til)	5134-5137
Antal sider	4
ISSN	1523-7060
DOI	https://doi.org/10.1021/ol902101c
Status	Udgivet - 19 nov. 2009

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10.1021/ol902101c

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abstract = "A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.",

author = "Petersen, {Trine P} and Andreas Ritz{\'e}n and Trond Ulven",

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AU - Ritzén, Andreas

AU - Ulven, Trond

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N2 - A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.

AB - A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.

U2 - 10.1021/ol902101c

DO - 10.1021/ol902101c

M3 - Journal article

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JO - Organic Letters

JF - Organic Letters

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A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

Abstract

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