A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges

Ali Kermanizadeh; Ilse Gosens; Laura MacCalman; Helinor Johnston; Pernille H. Danielsen; Nicklas R Jacobsen; Anke-Gabriele Lenz; Teresa Fernandes; Roel P F Schins; Flemming R Cassee; Håkan Wallin; Wolfgang Kreyling; Tobias Stoeger; Steffen Loft; Peter Møller; Lang Tran; Vicki Stone

doi:10.1080/10937404.2015.1126210

A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges

Ali Kermanizadeh, Ilse Gosens, Laura MacCalman, Helinor Johnston, Pernille H. Danielsen, Nicklas R Jacobsen, Anke-Gabriele Lenz, Teresa Fernandes, Roel P F Schins, Flemming R Cassee, Håkan Wallin, Wolfgang Kreyling, Tobias Stoeger, Steffen Loft, Peter Møller, Lang Tran, Vicki Stone

88 Citations (Scopus)

Abstract

ENPRA was one of the earlier multidisciplinary European Commission FP7-funded projects aiming to evaluate the risks associated with nanomaterial (NM) exposure on human health across pulmonary, cardiovascular, hepatic, renal, and developmental systems. The outputs from this project have formed the basis of this review. A retrospective interpretation of the findings across a wide range of in vitro and in vivo studies was performed to identify the main highlights from the project. In particular, focus was placed on informing what advances were made in the hazard assessment of NM, as well as offering some suggestions on the future of "nanotoxicology research" based on these observations, shortcomings, and lessons learned from the project. A number of issues related to the hazard assessment of NM are discussed in detail and include use of appropriate NM for nanotoxicology investigations; characterization and dispersion of NM; use of appropriate doses for all related investigations; need for the correct choice of experimental models for risk assessment purposes; and full understanding of the test systems and correct interpretation of data generated from in vitro and in vivo systems. It is hoped that this review may assist in providing information in the implementation of guidelines, model systems, validation of assessment methodology, and integrated testing approaches for risk assessment of NM. It is vital to learn from ongoing and/or completed studies to avoid unnecessary duplication and offer suggestions that might improve different aspects of experimental design.

Original language	English
Journal	Journal of toxicology and environmental health. Part B, Critical reviews
Volume	19
Issue number	1
Pages (from-to)	1-28
Number of pages	28
ISSN	1093-7404
DOIs	https://doi.org/10.1080/10937404.2015.1126210
Publication status	Published - 2 Jan 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10937404.2015.1126210

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Kermanizadeh, A., Gosens, I., MacCalman, L., Johnston, H., Danielsen, P. H., Jacobsen, N. R., Lenz, A.-G., Fernandes, T., Schins, R. P. F., Cassee, F. R., Wallin, H., Kreyling, W., Stoeger, T., Loft, S., Møller, P., Tran, L., & Stone, V. (2016). A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. Journal of toxicology and environmental health. Part B, Critical reviews, 19(1), 1-28. https://doi.org/10.1080/10937404.2015.1126210

A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. / Kermanizadeh, Ali; Gosens, Ilse; MacCalman, Laura et al.
In: Journal of toxicology and environmental health. Part B, Critical reviews, Vol. 19, No. 1, 02.01.2016, p. 1-28.

Research output: Contribution to journal › Review › peer-review

Kermanizadeh, A, Gosens, I, MacCalman, L, Johnston, H, Danielsen, PH, Jacobsen, NR, Lenz, A-G, Fernandes, T, Schins, RPF, Cassee, FR, Wallin, H, Kreyling, W, Stoeger, T, Loft, S , Møller, P, Tran, L & Stone, V 2016, 'A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges', Journal of toxicology and environmental health. Part B, Critical reviews, vol. 19, no. 1, pp. 1-28. https://doi.org/10.1080/10937404.2015.1126210

Kermanizadeh A, Gosens I, MacCalman L, Johnston H, Danielsen PH, Jacobsen NR et al. A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges. Journal of toxicology and environmental health. Part B, Critical reviews. 2016 Jan 2;19(1):1-28. doi: 10.1080/10937404.2015.1126210

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A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health: ENPRA Project - The Highlights, Limitations, and Current and Future Challenges

Abstract

Keywords

UN SDGs

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