A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

Tanveer A Bhuiyan; Claus Graff; Jørgen K Kanters; Jacob Melgaard; Egon Toft; Stefan Kääb; Johannes J Struijk

doi:10.1002/cpt.886

A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

Tanveer A Bhuiyan, Claus Graff, Jørgen K Kanters, Jacob Melgaard, Egon Toft, Stefan Kääb, Johannes J Struijk

Physiology of circulation, kidney and lung

2 Citations (Scopus)

Abstract

The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

Original language	English
Journal	Clinical Pharmacology and Therapeutics
Volume	103
Issue number	6
Pages (from-to)	1100-1106
Number of pages	7
ISSN	0009-9236
DOIs	https://doi.org/10.1002/cpt.886
Publication status	Published - 2018

Access to Document

10.1002/cpt.886

Cite this

@article{0c0d23ca97b54e598a1fee51a4ad28b6,

title = "A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities",

abstract = "The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.",

author = "Bhuiyan, {Tanveer A} and Claus Graff and Kanters, {J{\o}rgen K} and Jacob Melgaard and Egon Toft and Stefan K{\"a}{\"a}b and Struijk, {Johannes J}",

note = "{\textcopyright} 2017 American Society for Clinical Pharmacology and Therapeutics.",

year = "2018",

doi = "10.1002/cpt.886",

language = "English",

volume = "103",

pages = "1100--1106",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

publisher = "JohnWiley & Sons, Inc.",

number = "6",

}

TY - JOUR

T1 - A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

AU - Bhuiyan, Tanveer A

AU - Graff, Claus

AU - Kanters, Jørgen K

AU - Melgaard, Jacob

AU - Toft, Egon

AU - Kääb, Stefan

AU - Struijk, Johannes J

PY - 2018

Y1 - 2018

N2 - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

AB - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

UR - http://www.scopus.com/inward/record.url?scp=85032187887&partnerID=8YFLogxK

U2 - 10.1002/cpt.886

DO - 10.1002/cpt.886

M3 - Journal article

C2 - 28940299

SN - 0009-9236

VL - 103

SP - 1100

EP - 1106

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 6

ER -

A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

Abstract

Access to Document

Other files and links

Fingerprint

Cite this