A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

TY - JOUR

T1 - A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

AU - Bhuiyan, Tanveer A

AU - Graff, Claus

AU - Kanters, Jørgen K

AU - Melgaard, Jacob

AU - Toft, Egon

AU - Kääb, Stefan

AU - Struijk, Johannes J

N1 - © 2017 American Society for Clinical Pharmacology and Therapeutics.

PY - 2018

Y1 - 2018

N2 - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

AB - The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; -TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; -TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

UR - http://www.scopus.com/inward/record.url?scp=85032187887&partnerID=8YFLogxK

U2 - 10.1002/cpt.886

DO - 10.1002/cpt.886

M3 - Journal article

C2 - 28940299

SN - 0009-9236

VL - 103

SP - 1100

EP - 1106

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 6

ER -