A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date

Emilie Garnaes; Katalin Kiss; Luise Andersen; Marianne H Therkildsen; Maria B Franzmann; Bettina Filtenborg-Barnkob; Estrid Hoegdall; Lene Krenk; Michael Josiassen; Christel B Lajer; Lena Specht; Kirsten Frederiksen; Lennart Friis-Hansen; Finn C Nielsen; Susanne K Kjaer; Bodil Norrild; Christian von Buchwald

doi:10.1002/ijc.29254

A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date

Emilie Garnaes, Katalin Kiss, Luise Andersen, Marianne H Therkildsen, Maria B Franzmann, Bettina Filtenborg-Barnkob, Estrid Hoegdall, Lene Krenk, Michael Josiassen, Christel B Lajer, Lena Specht, Kirsten Frederiksen, Lennart Friis-Hansen, Finn C Nielsen, Susanne K Kjaer, Bodil Norrild, Christian von Buchwald

85 Citations (Scopus)

Abstract

The aim was to explore whether the incidence of tonsillar squamous cell carcinomas (TSCCs) increased in Eastern Denmark, 2000-2010, and whether human papillomavirus (HPV) could explain the increase, and to assess the association of HPV prevalence with gender, age, and origin (i.e., the certainty of tonsillar tumor origin). We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and in the Danish Pathology Data Bank (n = 632). Pathologists reviewed and subdivided the tumors into two groups: specified and nonspecified TSCCs. Approximately 10% of HPV-positive tumors was genotyped by amplicon next-generation sequencing. The overall crude incidence of TSCCs increased significantly (2.7% per year) and was explained by an increasing incidence of HPV-positive TSCCs (4.9% per year). The overall HPV prevalence was 58%, with HPV16 being the predominant HPV type. In multivariate analysis, the HPV prevalence was associated with age (<55 vs. >60 years) (OR, 1.72; 95% CI 1.13-2.63) and origin (nonspecified vs. specified TSCCs) (OR, 0.15; 95% CI 0.11-0.22). The association of HPV prevalence with origin increased over time in specified TSCCs (OR per year, 1.10; 95% CI 1.01-1.19), whereas no change over time was observed among nonspecified TSCCs (OR per year, 0.99; 95% CI 0.90-1.08). In conclusion, the observed increase in the number of HPV-positive TSCCs can explain the increasing number of TSCCs in Eastern Denmark, 2000-2010. HPV prevalence was associated with younger age (<55 years) and a high certainty of tonsillar tumor origin.

Original language	English
Journal	International journal of cancer. Journal international du cancer
Volume	136
Issue number	9
Pages (from-to)	2196-203
Number of pages	8
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.29254
Publication status	Published - 1 May 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ijc.29254

ijc.29254Final published version, 271 KB

Cite this

Garnaes, E., Kiss, K., Andersen, L., Therkildsen, M. H., Franzmann, M. B., Filtenborg-Barnkob, B., Hoegdall, E., Krenk, L., Josiassen, M., Lajer, C. B., Specht, L., Frederiksen, K., Friis-Hansen, L., Nielsen, F. C., Kjaer, S. K., Norrild, B., & von Buchwald, C. (2015). A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date. International journal of cancer. Journal international du cancer, 136(9), 2196-203. https://doi.org/10.1002/ijc.29254

A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010 : The largest registry-based study to date. / Garnaes, Emilie; Kiss, Katalin; Andersen, Luise et al.

In: International journal of cancer. Journal international du cancer, Vol. 136, No. 9, 01.05.2015, p. 2196-203.

Research output: Contribution to journal › Journal article › Research › peer-review

Garnaes, E, Kiss, K, Andersen, L, Therkildsen, MH, Franzmann, MB, Filtenborg-Barnkob, B, Hoegdall, E, Krenk, L, Josiassen, M, Lajer, CB, Specht, L, Frederiksen, K, Friis-Hansen, L , Nielsen, FC , Kjaer, SK, Norrild, B & von Buchwald, C 2015, 'A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date', International journal of cancer. Journal international du cancer, vol. 136, no. 9, pp. 2196-203. https://doi.org/10.1002/ijc.29254

@article{8aecf14d488f4a09b387b367a2c698c2,

title = "A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date",

abstract = "The aim was to explore whether the incidence of tonsillar squamous cell carcinomas (TSCCs) increased in Eastern Denmark, 2000-2010, and whether human papillomavirus (HPV) could explain the increase, and to assess the association of HPV prevalence with gender, age, and origin (i.e., the certainty of tonsillar tumor origin). We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and in the Danish Pathology Data Bank (n = 632). Pathologists reviewed and subdivided the tumors into two groups: specified and nonspecified TSCCs. Approximately 10% of HPV-positive tumors was genotyped by amplicon next-generation sequencing. The overall crude incidence of TSCCs increased significantly (2.7% per year) and was explained by an increasing incidence of HPV-positive TSCCs (4.9% per year). The overall HPV prevalence was 58%, with HPV16 being the predominant HPV type. In multivariate analysis, the HPV prevalence was associated with age (<55 vs. >60 years) (OR, 1.72; 95% CI 1.13-2.63) and origin (nonspecified vs. specified TSCCs) (OR, 0.15; 95% CI 0.11-0.22). The association of HPV prevalence with origin increased over time in specified TSCCs (OR per year, 1.10; 95% CI 1.01-1.19), whereas no change over time was observed among nonspecified TSCCs (OR per year, 0.99; 95% CI 0.90-1.08). In conclusion, the observed increase in the number of HPV-positive TSCCs can explain the increasing number of TSCCs in Eastern Denmark, 2000-2010. HPV prevalence was associated with younger age (<55 years) and a high certainty of tonsillar tumor origin.",

author = "Emilie Garnaes and Katalin Kiss and Luise Andersen and Therkildsen, {Marianne H} and Franzmann, {Maria B} and Bettina Filtenborg-Barnkob and Estrid Hoegdall and Lene Krenk and Michael Josiassen and Lajer, {Christel B} and Lena Specht and Kirsten Frederiksen and Lennart Friis-Hansen and Nielsen, {Finn C} and Kjaer, {Susanne K} and Bodil Norrild and {von Buchwald}, Christian",

note = "{\textcopyright} 2014 UICC.",

year = "2015",

month = may,

day = "1",

doi = "10.1002/ijc.29254",

language = "English",

volume = "136",

pages = "2196--203",

journal = "Radiation Oncology Investigations",

issn = "0020-7136",

publisher = "JohnWiley & Sons, Inc.",

number = "9",

}

TY - JOUR

T1 - A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010

T2 - The largest registry-based study to date

AU - Garnaes, Emilie

AU - Kiss, Katalin

AU - Andersen, Luise

AU - Therkildsen, Marianne H

AU - Franzmann, Maria B

AU - Filtenborg-Barnkob, Bettina

AU - Hoegdall, Estrid

AU - Krenk, Lene

AU - Josiassen, Michael

AU - Lajer, Christel B

AU - Specht, Lena

AU - Frederiksen, Kirsten

AU - Friis-Hansen, Lennart

AU - Nielsen, Finn C

AU - Kjaer, Susanne K

AU - Norrild, Bodil

AU - von Buchwald, Christian

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The aim was to explore whether the incidence of tonsillar squamous cell carcinomas (TSCCs) increased in Eastern Denmark, 2000-2010, and whether human papillomavirus (HPV) could explain the increase, and to assess the association of HPV prevalence with gender, age, and origin (i.e., the certainty of tonsillar tumor origin). We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and in the Danish Pathology Data Bank (n = 632). Pathologists reviewed and subdivided the tumors into two groups: specified and nonspecified TSCCs. Approximately 10% of HPV-positive tumors was genotyped by amplicon next-generation sequencing. The overall crude incidence of TSCCs increased significantly (2.7% per year) and was explained by an increasing incidence of HPV-positive TSCCs (4.9% per year). The overall HPV prevalence was 58%, with HPV16 being the predominant HPV type. In multivariate analysis, the HPV prevalence was associated with age (<55 vs. >60 years) (OR, 1.72; 95% CI 1.13-2.63) and origin (nonspecified vs. specified TSCCs) (OR, 0.15; 95% CI 0.11-0.22). The association of HPV prevalence with origin increased over time in specified TSCCs (OR per year, 1.10; 95% CI 1.01-1.19), whereas no change over time was observed among nonspecified TSCCs (OR per year, 0.99; 95% CI 0.90-1.08). In conclusion, the observed increase in the number of HPV-positive TSCCs can explain the increasing number of TSCCs in Eastern Denmark, 2000-2010. HPV prevalence was associated with younger age (<55 years) and a high certainty of tonsillar tumor origin.

AB - The aim was to explore whether the incidence of tonsillar squamous cell carcinomas (TSCCs) increased in Eastern Denmark, 2000-2010, and whether human papillomavirus (HPV) could explain the increase, and to assess the association of HPV prevalence with gender, age, and origin (i.e., the certainty of tonsillar tumor origin). We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and in the Danish Pathology Data Bank (n = 632). Pathologists reviewed and subdivided the tumors into two groups: specified and nonspecified TSCCs. Approximately 10% of HPV-positive tumors was genotyped by amplicon next-generation sequencing. The overall crude incidence of TSCCs increased significantly (2.7% per year) and was explained by an increasing incidence of HPV-positive TSCCs (4.9% per year). The overall HPV prevalence was 58%, with HPV16 being the predominant HPV type. In multivariate analysis, the HPV prevalence was associated with age (<55 vs. >60 years) (OR, 1.72; 95% CI 1.13-2.63) and origin (nonspecified vs. specified TSCCs) (OR, 0.15; 95% CI 0.11-0.22). The association of HPV prevalence with origin increased over time in specified TSCCs (OR per year, 1.10; 95% CI 1.01-1.19), whereas no change over time was observed among nonspecified TSCCs (OR per year, 0.99; 95% CI 0.90-1.08). In conclusion, the observed increase in the number of HPV-positive TSCCs can explain the increasing number of TSCCs in Eastern Denmark, 2000-2010. HPV prevalence was associated with younger age (<55 years) and a high certainty of tonsillar tumor origin.

U2 - 10.1002/ijc.29254

DO - 10.1002/ijc.29254

M3 - Journal article

C2 - 25283302

SN - 0020-7136

VL - 136

SP - 2196

EP - 2203

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 9

ER -

A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: The largest registry-based study to date

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this