A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

Josephine Purps; Sabine Siegert; Sascha Willuweit; Marion Nagy; Cíntia Alves; Renato Salazar; Sheila M T Angustia; Lorna H Santos; Katja Anslinger; Birgit Bayer; Qasim Ayub; Wei Wei; Yali Xue; Chris Tyler-Smith; Miriam Baeta Bafalluy; Begoña Martínez-Jarreta; Balazs Egyed; Beate Balitzki; Sibylle Tschumi; David Ballard; Denise Syndercombe Court; Xinia Barrantes; Gerhard Bäßler; Tina Wiest; Burkhard Berger; Harald Niederstätter; Walther Parson; Carey Davis; Bruce Budowle; Helen Burri; Urs Borer; Christoph Koller; Elizeu F Carvalho; Patricia M Domingues; Wafaa Takash Chamoun; Michael D Coble; Carolyn R Hill; Daniel Corach; Mariela Caputo; Maria E D'Amato; Sean Davison; Ronny Decorte; Maarten H D Larmuseau; Claudio Ottoni; Olga Rickards; Di Lu; Chengtao Jiang; Tadeusz Dobosz; Anna Jonkisz; William E Frank; Ivana Furac; Christian Gehrig; Vincent Castella; Branka Grskovic; Cordula Haas; Jana Wobst; Gavrilo Hadzic; Katja Drobnic; Katsuya Honda; Yiping Hou; Di Zhou; Yan Li; Shengping Hu; Shenglan Chen; Uta-Dorothee Immel; Rüdiger Lessig; Zlatko Jakovski; Tanja Ilievska; Anja E Klann; Cristina Cano García; Peter de Knijff; Thirsa Kraaijenbrink; Aikaterini Kondili; Penelope Miniati; Maria Vouropoulou; Lejla Kovacevic; Damir Marjanovic; Iris Lindner; Issam Mansour; Mouayyad Al-Azem; Ansar El Andari; Miguel Marino; Sandra Furfuro; Laura Locarno; Pablo Martín; Gracia M Luque; Antonio Alonso; Luís Souto Miranda; Helena Moreira; Natsuko Mizuno; Yasuki Iwashima; Rodrigo S Moura Neto; Tatiana L S Nogueira; Rosane Silva; Marina Nastainczyk-Wulf; Jeanett Edelmann; Michael Kohl; Shengjie Nie; Xianping Wang; Baowen Cheng; Carolina Núñez; Marian Martínez de Pancorbo; Jill Katharina Olofsson; Niels Morling; Valerio Onofri; Adriano Tagliabracci; Horolma Pamjav; Antonia Volgyi; Gusztav Barany; Ryszard Pawlowski; Agnieszka Maciejewska; Susi Pelotti; Witold Pepinski; Monica Abreu-Glowacka; Christopher Phillips; Jorge Cárdenas; Danel Rey-Gonzalez; Antonio Salas; Francesca Brisighelli; Cristian Capelli; Ulises Toscanini; Andrea Piccinini; Marilidia Piglionica; Stefania L Baldassarra; Rafal Ploski; Magdalena Konarzewska; Emila Jastrzebska; Carlo Robino; Antti Sajantila; Jukka U Palo; Evelyn Guevara; Jazelyn Salvador; Maria Corazon De Ungria; Jae Joseph Russell Rodriguez; Ulrike Schmidt; Nicola Schlauderer; Pekka Saukko; Peter M Schneider; Miriam Sirker; Kyoung-Jin Shin; Yu Na Oh; Iulia Skitsa; Alexandra Ampati; Tobi-Gail Smith; Lina Solis de Calvit; Vlastimil Stenzl; Thomas Capal; Andreas Tillmar; Helena Nilsson; Stefania Turrina; Domenico De Leo; Andrea Verzeletti; Venusia Cortellini; Jon H Wetton; Gareth M Gwynne; Mark A Jobling; Martin R Whittle; Denilce R Sumita; Paulina Wolańska-Nowak; Rita Y Y Yong; Michael Krawczak; Michael Nothnagel; Lutz Roewer

doi:10.1016/j.fsigen.2014.04.008

A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

Josephine Purps, Sabine Siegert, Sascha Willuweit, Marion Nagy, Cíntia Alves, Renato Salazar, Sheila M T Angustia, Lorna H Santos, Katja Anslinger, Birgit Bayer, Qasim Ayub, Wei Wei, Yali Xue, Chris Tyler-Smith, Miriam Baeta Bafalluy, Begoña Martínez-Jarreta, Balazs Egyed, Beate Balitzki, Sibylle Tschumi, David BallardDenise Syndercombe Court, Xinia Barrantes, Gerhard Bäßler, Tina Wiest, Burkhard Berger, Harald Niederstätter, Walther Parson, Carey Davis, Bruce Budowle, Helen Burri, Urs Borer, Christoph Koller, Elizeu F Carvalho, Patricia M Domingues, Wafaa Takash Chamoun, Michael D Coble, Carolyn R Hill, Daniel Corach, Mariela Caputo, Maria E D'Amato, Sean Davison, Ronny Decorte, Maarten H D Larmuseau, Claudio Ottoni, Olga Rickards, Di Lu, Chengtao Jiang, Tadeusz Dobosz, Anna Jonkisz, William E Frank, Ivana Furac, Christian Gehrig, Vincent Castella, Branka Grskovic, Cordula Haas, Jana Wobst, Gavrilo Hadzic, Katja Drobnic, Katsuya Honda, Yiping Hou, Di Zhou, Yan Li, Shengping Hu, Shenglan Chen, Uta-Dorothee Immel, Rüdiger Lessig, Zlatko Jakovski, Tanja Ilievska, Anja E Klann, Cristina Cano García, Peter de Knijff, Thirsa Kraaijenbrink, Aikaterini Kondili, Penelope Miniati, Maria Vouropoulou, Lejla Kovacevic, Damir Marjanovic, Iris Lindner, Issam Mansour, Mouayyad Al-Azem, Ansar El Andari, Miguel Marino, Sandra Furfuro, Laura Locarno, Pablo Martín, Gracia M Luque, Antonio Alonso, Luís Souto Miranda, Helena Moreira, Natsuko Mizuno, Yasuki Iwashima, Rodrigo S Moura Neto, Tatiana L S Nogueira, Rosane Silva, Marina Nastainczyk-Wulf, Jeanett Edelmann, Michael Kohl, Shengjie Nie, Xianping Wang, Baowen Cheng, Carolina Núñez, Marian Martínez de Pancorbo, Jill Katharina Olofsson, Niels Morling, Valerio Onofri, Adriano Tagliabracci, Horolma Pamjav, Antonia Volgyi, Gusztav Barany, Ryszard Pawlowski, Agnieszka Maciejewska, Susi Pelotti, Witold Pepinski, Monica Abreu-Glowacka, Christopher Phillips, Jorge Cárdenas, Danel Rey-Gonzalez, Antonio Salas, Francesca Brisighelli, Cristian Capelli, Ulises Toscanini, Andrea Piccinini, Marilidia Piglionica, Stefania L Baldassarra, Rafal Ploski, Magdalena Konarzewska, Emila Jastrzebska, Carlo Robino, Antti Sajantila, Jukka U Palo, Evelyn Guevara, Jazelyn Salvador, Maria Corazon De Ungria, Jae Joseph Russell Rodriguez, Ulrike Schmidt, Nicola Schlauderer, Pekka Saukko, Peter M Schneider, Miriam Sirker, Kyoung-Jin Shin, Yu Na Oh, Iulia Skitsa, Alexandra Ampati, Tobi-Gail Smith, Lina Solis de Calvit, Vlastimil Stenzl, Thomas Capal, Andreas Tillmar, Helena Nilsson, Stefania Turrina, Domenico De Leo, Andrea Verzeletti, Venusia Cortellini, Jon H Wetton, Gareth M Gwynne, Mark A Jobling, Martin R Whittle, Denilce R Sumita, Paulina Wolańska-Nowak, Rita Y Y Yong, Michael Krawczak, Michael Nothnagel, Lutz Roewer

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Abstract

In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.

Original language	English
Journal	Forensic science international. Genetics
Volume	12
Pages (from-to)	12-23
Number of pages	12
DOIs	https://doi.org/10.1016/j.fsigen.2014.04.008
Publication status	Published - Sept 2014

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10.1016/j.fsigen.2014.04.008

A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

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Purps, J., Siegert, S., Willuweit, S., Nagy, M., Alves, C., Salazar, R., Angustia, S. M. T., Santos, L. H., Anslinger, K., Bayer, B., Ayub, Q., Wei, W., Xue, Y., Tyler-Smith, C., Bafalluy, M. B., Martínez-Jarreta, B., Egyed, B., Balitzki, B., Tschumi, S., ... Roewer, L. (2014). A global analysis of Y-chromosomal haplotype diversity for 23 STR loci. Forensic science international. Genetics, 12, 12-23. https://doi.org/10.1016/j.fsigen.2014.04.008

Purps, J, Siegert, S, Willuweit, S, Nagy, M, Alves, C, Salazar, R, Angustia, SMT, Santos, LH, Anslinger, K, Bayer, B, Ayub, Q, Wei, W, Xue, Y, Tyler-Smith, C, Bafalluy, MB, Martínez-Jarreta, B, Egyed, B, Balitzki, B, Tschumi, S, Ballard, D, Court, DS, Barrantes, X, Bäßler, G, Wiest, T, Berger, B, Niederstätter, H, Parson, W, Davis, C, Budowle, B, Burri, H, Borer, U, Koller, C, Carvalho, EF, Domingues, PM, Chamoun, WT, Coble, MD, Hill, CR, Corach, D, Caputo, M, D'Amato, ME, Davison, S, Decorte, R, Larmuseau, MHD, Ottoni, C, Rickards, O, Lu, D, Jiang, C, Dobosz, T, Jonkisz, A, Frank, WE, Furac, I, Gehrig, C, Castella, V, Grskovic, B, Haas, C, Wobst, J, Hadzic, G, Drobnic, K, Honda, K, Hou, Y, Zhou, D, Li, Y, Hu, S, Chen, S, Immel, U-D, Lessig, R, Jakovski, Z, Ilievska, T, Klann, AE, García, CC, de Knijff, P, Kraaijenbrink, T, Kondili, A, Miniati, P, Vouropoulou, M, Kovacevic, L, Marjanovic, D, Lindner, I, Mansour, I, Al-Azem, M, Andari, AE, Marino, M, Furfuro, S, Locarno, L, Martín, P, Luque, GM, Alonso, A, Miranda, LS, Moreira, H, Mizuno, N, Iwashima, Y, Neto, RSM, Nogueira, TLS, Silva, R, Nastainczyk-Wulf, M, Edelmann, J, Kohl, M, Nie, S, Wang, X, Cheng, B, Núñez, C, Pancorbo, MMD, Olofsson, JK , Morling, N, Onofri, V, Tagliabracci, A, Pamjav, H, Volgyi, A, Barany, G, Pawlowski, R, Maciejewska, A, Pelotti, S, Pepinski, W, Abreu-Glowacka, M, Phillips, C, Cárdenas, J, Rey-Gonzalez, D, Salas, A, Brisighelli, F, Capelli, C, Toscanini, U, Piccinini, A, Piglionica, M, Baldassarra, SL, Ploski, R, Konarzewska, M, Jastrzebska, E, Robino, C, Sajantila, A, Palo, JU, Guevara, E, Salvador, J, Ungria, MCD, Rodriguez, JJR, Schmidt, U, Schlauderer, N, Saukko, P, Schneider, PM, Sirker, M, Shin, K-J, Oh, YN, Skitsa, I, Ampati, A, Smith, T-G, Calvit, LSD, Stenzl, V, Capal, T, Tillmar, A, Nilsson, H, Turrina, S, De Leo, D, Verzeletti, A, Cortellini, V, Wetton, JH, Gwynne, GM, Jobling, MA, Whittle, MR, Sumita, DR, Wolańska-Nowak, P, Yong, RYY, Krawczak, M, Nothnagel, M & Roewer, L 2014, 'A global analysis of Y-chromosomal haplotype diversity for 23 STR loci', Forensic science international. Genetics, vol. 12, pp. 12-23. https://doi.org/10.1016/j.fsigen.2014.04.008

@article{64618639059042ffa3c5054e6f4e3297,

title = "A global analysis of Y-chromosomal haplotype diversity for 23 STR loci",

abstract = "In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.",

author = "Josephine Purps and Sabine Siegert and Sascha Willuweit and Marion Nagy and C{\'i}ntia Alves and Renato Salazar and Angustia, {Sheila M T} and Santos, {Lorna H} and Katja Anslinger and Birgit Bayer and Qasim Ayub and Wei Wei and Yali Xue and Chris Tyler-Smith and Bafalluy, {Miriam Baeta} and Bego{\~n}a Mart{\'i}nez-Jarreta and Balazs Egyed and Beate Balitzki and Sibylle Tschumi and David Ballard and Court, {Denise Syndercombe} and Xinia Barrantes and Gerhard B{\"a}{\ss}ler and Tina Wiest and Burkhard Berger and Harald Niederst{\"a}tter and Walther Parson and Carey Davis and Bruce Budowle and Helen Burri and Urs Borer and Christoph Koller and Carvalho, {Elizeu F} and Domingues, {Patricia M} and Chamoun, {Wafaa Takash} and Coble, {Michael D} and Hill, {Carolyn R} and Daniel Corach and Mariela Caputo and D'Amato, {Maria E} and Sean Davison and Ronny Decorte and Larmuseau, {Maarten H D} and Claudio Ottoni and Olga Rickards and Di Lu and Chengtao Jiang and Tadeusz Dobosz and Anna Jonkisz and Frank, {William E} and Ivana Furac and Christian Gehrig and Vincent Castella and Branka Grskovic and Cordula Haas and Jana Wobst and Gavrilo Hadzic and Katja Drobnic and Katsuya Honda and Yiping Hou and Di Zhou and Yan Li and Shengping Hu and Shenglan Chen and Uta-Dorothee Immel and R{\"u}diger Lessig and Zlatko Jakovski and Tanja Ilievska and Klann, {Anja E} and Garc{\'i}a, {Cristina Cano} and {de Knijff}, Peter and Thirsa Kraaijenbrink and Aikaterini Kondili and Penelope Miniati and Maria Vouropoulou and Lejla Kovacevic and Damir Marjanovic and Iris Lindner and Issam Mansour and Mouayyad Al-Azem and Andari, {Ansar El} and Miguel Marino and Sandra Furfuro and Laura Locarno and Pablo Mart{\'i}n and Luque, {Gracia M} and Antonio Alonso and Miranda, {Lu{\'i}s Souto} and Helena Moreira and Natsuko Mizuno and Yasuki Iwashima and Neto, {Rodrigo S Moura} and Nogueira, {Tatiana L S} and Rosane Silva and Marina Nastainczyk-Wulf and Jeanett Edelmann and Michael Kohl and Shengjie Nie and Xianping Wang and Baowen Cheng and Carolina N{\'u}{\~n}ez and Pancorbo, {Marian Mart{\'i}nez de} and Olofsson, {Jill Katharina} and Niels Morling and Valerio Onofri and Adriano Tagliabracci and Horolma Pamjav and Antonia Volgyi and Gusztav Barany and Ryszard Pawlowski and Agnieszka Maciejewska and Susi Pelotti and Witold Pepinski and Monica Abreu-Glowacka and Christopher Phillips and Jorge C{\'a}rdenas and Danel Rey-Gonzalez and Antonio Salas and Francesca Brisighelli and Cristian Capelli and Ulises Toscanini and Andrea Piccinini and Marilidia Piglionica and Baldassarra, {Stefania L} and Rafal Ploski and Magdalena Konarzewska and Emila Jastrzebska and Carlo Robino and Antti Sajantila and Palo, {Jukka U} and Evelyn Guevara and Jazelyn Salvador and Ungria, {Maria Corazon De} and Rodriguez, {Jae Joseph Russell} and Ulrike Schmidt and Nicola Schlauderer and Pekka Saukko and Schneider, {Peter M} and Miriam Sirker and Kyoung-Jin Shin and Oh, {Yu Na} and Iulia Skitsa and Alexandra Ampati and Tobi-Gail Smith and Calvit, {Lina Solis de} and Vlastimil Stenzl and Thomas Capal and Andreas Tillmar and Helena Nilsson and Stefania Turrina and {De Leo}, Domenico and Andrea Verzeletti and Venusia Cortellini and Wetton, {Jon H} and Gwynne, {Gareth M} and Jobling, {Mark A} and Whittle, {Martin R} and Sumita, {Denilce R} and Paulina Wola{\'n}ska-Nowak and Yong, {Rita Y Y} and Michael Krawczak and Michael Nothnagel and Lutz Roewer",

year = "2014",

month = sep,

doi = "10.1016/j.fsigen.2014.04.008",

language = "English",

volume = "12",

pages = "12--23",

journal = "Forensic Science International: Genetics",

issn = "1872-4973",

publisher = "Elsevier",

}

TY - JOUR

T1 - A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

AU - Purps, Josephine

AU - Siegert, Sabine

AU - Willuweit, Sascha

AU - Nagy, Marion

AU - Alves, Cíntia

AU - Salazar, Renato

AU - Angustia, Sheila M T

AU - Santos, Lorna H

AU - Anslinger, Katja

AU - Bayer, Birgit

AU - Ayub, Qasim

AU - Wei, Wei

AU - Xue, Yali

AU - Tyler-Smith, Chris

AU - Bafalluy, Miriam Baeta

AU - Martínez-Jarreta, Begoña

AU - Egyed, Balazs

AU - Balitzki, Beate

AU - Tschumi, Sibylle

AU - Ballard, David

AU - Court, Denise Syndercombe

AU - Barrantes, Xinia

AU - Bäßler, Gerhard

AU - Wiest, Tina

AU - Berger, Burkhard

AU - Niederstätter, Harald

AU - Parson, Walther

AU - Davis, Carey

AU - Budowle, Bruce

AU - Burri, Helen

AU - Borer, Urs

AU - Koller, Christoph

AU - Carvalho, Elizeu F

AU - Domingues, Patricia M

AU - Chamoun, Wafaa Takash

AU - Coble, Michael D

AU - Hill, Carolyn R

AU - Corach, Daniel

AU - Caputo, Mariela

AU - D'Amato, Maria E

AU - Davison, Sean

AU - Decorte, Ronny

AU - Larmuseau, Maarten H D

AU - Ottoni, Claudio

AU - Rickards, Olga

AU - Lu, Di

AU - Jiang, Chengtao

AU - Dobosz, Tadeusz

AU - Jonkisz, Anna

AU - Frank, William E

AU - Furac, Ivana

AU - Gehrig, Christian

AU - Castella, Vincent

AU - Grskovic, Branka

AU - Haas, Cordula

AU - Wobst, Jana

AU - Hadzic, Gavrilo

AU - Drobnic, Katja

AU - Honda, Katsuya

AU - Hou, Yiping

AU - Zhou, Di

AU - Li, Yan

AU - Hu, Shengping

AU - Chen, Shenglan

AU - Immel, Uta-Dorothee

AU - Lessig, Rüdiger

AU - Jakovski, Zlatko

AU - Ilievska, Tanja

AU - Klann, Anja E

AU - García, Cristina Cano

AU - de Knijff, Peter

AU - Kraaijenbrink, Thirsa

AU - Kondili, Aikaterini

AU - Miniati, Penelope

AU - Vouropoulou, Maria

AU - Kovacevic, Lejla

AU - Marjanovic, Damir

AU - Lindner, Iris

AU - Mansour, Issam

AU - Al-Azem, Mouayyad

AU - Andari, Ansar El

AU - Marino, Miguel

AU - Furfuro, Sandra

AU - Locarno, Laura

AU - Martín, Pablo

AU - Luque, Gracia M

AU - Alonso, Antonio

AU - Miranda, Luís Souto

AU - Moreira, Helena

AU - Mizuno, Natsuko

AU - Iwashima, Yasuki

AU - Neto, Rodrigo S Moura

AU - Nogueira, Tatiana L S

AU - Silva, Rosane

AU - Nastainczyk-Wulf, Marina

AU - Edelmann, Jeanett

AU - Kohl, Michael

AU - Nie, Shengjie

AU - Wang, Xianping

AU - Cheng, Baowen

AU - Núñez, Carolina

AU - Pancorbo, Marian Martínez de

AU - Olofsson, Jill Katharina

AU - Morling, Niels

AU - Onofri, Valerio

AU - Tagliabracci, Adriano

AU - Pamjav, Horolma

AU - Volgyi, Antonia

AU - Barany, Gusztav

AU - Pawlowski, Ryszard

AU - Maciejewska, Agnieszka

AU - Pelotti, Susi

AU - Pepinski, Witold

AU - Abreu-Glowacka, Monica

AU - Phillips, Christopher

AU - Cárdenas, Jorge

AU - Rey-Gonzalez, Danel

AU - Salas, Antonio

AU - Brisighelli, Francesca

AU - Capelli, Cristian

AU - Toscanini, Ulises

AU - Piccinini, Andrea

AU - Piglionica, Marilidia

AU - Baldassarra, Stefania L

AU - Ploski, Rafal

AU - Konarzewska, Magdalena

AU - Jastrzebska, Emila

AU - Robino, Carlo

AU - Sajantila, Antti

AU - Palo, Jukka U

AU - Guevara, Evelyn

AU - Salvador, Jazelyn

AU - Ungria, Maria Corazon De

AU - Rodriguez, Jae Joseph Russell

AU - Schmidt, Ulrike

AU - Schlauderer, Nicola

AU - Saukko, Pekka

AU - Schneider, Peter M

AU - Sirker, Miriam

AU - Shin, Kyoung-Jin

AU - Oh, Yu Na

AU - Skitsa, Iulia

AU - Ampati, Alexandra

AU - Smith, Tobi-Gail

AU - Calvit, Lina Solis de

AU - Stenzl, Vlastimil

AU - Capal, Thomas

AU - Tillmar, Andreas

AU - Nilsson, Helena

AU - Turrina, Stefania

AU - De Leo, Domenico

AU - Verzeletti, Andrea

AU - Cortellini, Venusia

AU - Wetton, Jon H

AU - Gwynne, Gareth M

AU - Jobling, Mark A

AU - Whittle, Martin R

AU - Sumita, Denilce R

AU - Wolańska-Nowak, Paulina

AU - Yong, Rita Y Y

AU - Krawczak, Michael

AU - Nothnagel, Michael

AU - Roewer, Lutz

PY - 2014/9

Y1 - 2014/9

N2 - In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.

AB - In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.

U2 - 10.1016/j.fsigen.2014.04.008

DO - 10.1016/j.fsigen.2014.04.008

M3 - Journal article

C2 - 24854874

SN - 1872-4973

VL - 12

SP - 12

EP - 23

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

ER -

A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

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