A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Eleanor Raffan; Rowena J Dennis; Conor J O'Donovan; Julia M Becker; Robert A Scott; Stephen P Smith; David J Withers; Claire J Wood; Elena Conci; Dylan N Clements; Kim M Summers; Alexander J German; Cathryn S Mellersh; Maja L Arendt; Valentine P Iyemere; Elaine Withers; Josefin Söder; Sara Wernersson; Göran Andersson; Kerstin Lindblad-Toh; Giles S H Yeo; Stephen O'Rahilly

doi:10.1016/j.cmet.2016.04.012

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Eleanor Raffan, Rowena J Dennis, Conor J O'Donovan, Julia M Becker, Robert A Scott, Stephen P Smith, David J Withers, Claire J Wood, Elena Conci, Dylan N Clements, Kim M Summers, Alexander J German, Cathryn S Mellersh, Maja L Arendt, Valentine P Iyemere, Elaine Withers, Josefin Söder, Sara Wernersson, Göran Andersson, Kerstin Lindblad-TohGiles S H Yeo, Stephen O'Rahilly

61 Citations (Scopus)

Abstract

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

Original language	English
Journal	Cell Metabolism
Volume	23
Issue number	5
Pages (from-to)	893-900
Number of pages	8
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2016.04.012
Publication status	Published - 10 May 2016
Externally published	Yes

Keywords

Adiposity/genetics
Amino Acid Sequence
Animals
Appetite/genetics
Base Pairing
Base Sequence
Body Weight/genetics
COS Cells
Cercopithecus aethiops
Dogs
Feeding Behavior
Gene Deletion
Genotype
Obesity/genetics
Pro-Opiomelanocortin/chemistry
Receptors, Melanocortin/metabolism
beta-MSH/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Raffan, E., Dennis, R. J., O'Donovan, C. J., Becker, J. M., Scott, R. A., Smith, S. P., Withers, D. J., Wood, C. J., Conci, E., Clements, D. N., Summers, K. M., German, A. J., Mellersh, C. S., Arendt, M. L., Iyemere, V. P., Withers, E., Söder, J., Wernersson, S., Andersson, G., ... O'Rahilly, S. (2016). A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism, 23(5), 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

Raffan, E, Dennis, RJ, O'Donovan, CJ, Becker, JM, Scott, RA, Smith, SP, Withers, DJ, Wood, CJ, Conci, E, Clements, DN, Summers, KM, German, AJ, Mellersh, CS, Arendt, ML, Iyemere, VP, Withers, E, Söder, J, Wernersson, S, Andersson, G, Lindblad-Toh, K, Yeo, GSH & O'Rahilly, S 2016, 'A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs', Cell Metabolism, vol. 23, no. 5, pp. 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

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title = "A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs",

abstract = "Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.",

keywords = "Adiposity/genetics, Amino Acid Sequence, Animals, Appetite/genetics, Base Pairing, Base Sequence, Body Weight/genetics, COS Cells, Cercopithecus aethiops, Dogs, Feeding Behavior, Gene Deletion, Genotype, Obesity/genetics, Pro-Opiomelanocortin/chemistry, Receptors, Melanocortin/metabolism, beta-MSH/metabolism",

author = "Eleanor Raffan and Dennis, {Rowena J} and O'Donovan, {Conor J} and Becker, {Julia M} and Scott, {Robert A} and Smith, {Stephen P} and Withers, {David J} and Wood, {Claire J} and Elena Conci and Clements, {Dylan N} and Summers, {Kim M} and German, {Alexander J} and Mellersh, {Cathryn S} and Arendt, {Maja L} and Iyemere, {Valentine P} and Elaine Withers and Josefin S{\"o}der and Sara Wernersson and G{\"o}ran Andersson and Kerstin Lindblad-Toh and Yeo, {Giles S H} and Stephen O'Rahilly",

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T1 - A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

AU - Raffan, Eleanor

AU - Dennis, Rowena J

AU - O'Donovan, Conor J

AU - Becker, Julia M

AU - Scott, Robert A

AU - Smith, Stephen P

AU - Withers, David J

AU - Wood, Claire J

AU - Conci, Elena

AU - Clements, Dylan N

AU - Summers, Kim M

AU - German, Alexander J

AU - Mellersh, Cathryn S

AU - Arendt, Maja L

AU - Iyemere, Valentine P

AU - Withers, Elaine

AU - Söder, Josefin

AU - Wernersson, Sara

AU - Andersson, Göran

AU - Lindblad-Toh, Kerstin

AU - Yeo, Giles S H

AU - O'Rahilly, Stephen

PY - 2016/5/10

Y1 - 2016/5/10

N2 - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

AB - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

KW - Adiposity/genetics

KW - Amino Acid Sequence

KW - Animals

KW - Appetite/genetics

KW - Base Pairing

KW - Base Sequence

KW - Body Weight/genetics

KW - COS Cells

KW - Cercopithecus aethiops

KW - Dogs

KW - Feeding Behavior

KW - Gene Deletion

KW - Genotype

KW - Obesity/genetics

KW - Pro-Opiomelanocortin/chemistry

KW - Receptors, Melanocortin/metabolism

KW - beta-MSH/metabolism

U2 - 10.1016/j.cmet.2016.04.012

DO - 10.1016/j.cmet.2016.04.012

M3 - Journal article

C2 - 27157046

SN - 1550-4131

VL - 23

SP - 893

EP - 900

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Abstract

Keywords

UN SDGs

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