A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Eleanor Raffan; Rowena J Dennis; Conor J O'Donovan; Julia M Becker; Robert A Scott; Stephen P Smith; David J Withers; Claire J Wood; Elena Conci; Dylan N Clements; Kim M Summers; Alexander J German; Cathryn S Mellersh; Maja L Arendt; Valentine P Iyemere; Elaine Withers; Josefin Söder; Sara Wernersson; Göran Andersson; Kerstin Lindblad-Toh; Giles S H Yeo; Stephen O'Rahilly

doi:10.1016/j.cmet.2016.04.012

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Eleanor Raffan, Rowena J Dennis, Conor J O'Donovan, Julia M Becker, Robert A Scott, Stephen P Smith, David J Withers, Claire J Wood, Elena Conci, Dylan N Clements, Kim M Summers, Alexander J German, Cathryn S Mellersh, Maja L Arendt, Valentine P Iyemere, Elaine Withers, Josefin Söder, Sara Wernersson, Göran Andersson, Kerstin Lindblad-TohGiles S H Yeo, Stephen O'Rahilly

61 Citationer (Scopus)

Abstract

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

Originalsprog	Engelsk
Tidsskrift	Cell Metabolism
Vol/bind	23
Udgave nummer	5
Sider (fra-til)	893-900
Antal sider	8
ISSN	1550-4131
DOI	https://doi.org/10.1016/j.cmet.2016.04.012
Status	Udgivet - 10 maj 2016
Udgivet eksternt	Ja

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10.1016/j.cmet.2016.04.012Licens: CC BY

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Raffan, E., Dennis, R. J., O'Donovan, C. J., Becker, J. M., Scott, R. A., Smith, S. P., Withers, D. J., Wood, C. J., Conci, E., Clements, D. N., Summers, K. M., German, A. J., Mellersh, C. S., Arendt, M. L., Iyemere, V. P., Withers, E., Söder, J., Wernersson, S., Andersson, G., ... O'Rahilly, S. (2016). A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism, 23(5), 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

Raffan, E, Dennis, RJ, O'Donovan, CJ, Becker, JM, Scott, RA, Smith, SP, Withers, DJ, Wood, CJ, Conci, E, Clements, DN, Summers, KM, German, AJ, Mellersh, CS, Arendt, ML, Iyemere, VP, Withers, E, Söder, J, Wernersson, S, Andersson, G, Lindblad-Toh, K, Yeo, GSH & O'Rahilly, S 2016, 'A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs', Cell Metabolism, bind 23, nr. 5, s. 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

@article{9c114decd4284580950c200292b91fed,

title = "A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs",

abstract = "Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.",

keywords = "Adiposity/genetics, Amino Acid Sequence, Animals, Appetite/genetics, Base Pairing, Base Sequence, Body Weight/genetics, COS Cells, Cercopithecus aethiops, Dogs, Feeding Behavior, Gene Deletion, Genotype, Obesity/genetics, Pro-Opiomelanocortin/chemistry, Receptors, Melanocortin/metabolism, beta-MSH/metabolism",

author = "Eleanor Raffan and Dennis, {Rowena J} and O'Donovan, {Conor J} and Becker, {Julia M} and Scott, {Robert A} and Smith, {Stephen P} and Withers, {David J} and Wood, {Claire J} and Elena Conci and Clements, {Dylan N} and Summers, {Kim M} and German, {Alexander J} and Mellersh, {Cathryn S} and Arendt, {Maja L} and Iyemere, {Valentine P} and Elaine Withers and Josefin S{\"o}der and Sara Wernersson and G{\"o}ran Andersson and Kerstin Lindblad-Toh and Yeo, {Giles S H} and Stephen O'Rahilly",

year = "2016",

month = may,

day = "10",

doi = "10.1016/j.cmet.2016.04.012",

language = "English",

volume = "23",

pages = "893--900",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "5",

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TY - JOUR

T1 - A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

AU - Raffan, Eleanor

AU - Dennis, Rowena J

AU - O'Donovan, Conor J

AU - Becker, Julia M

AU - Scott, Robert A

AU - Smith, Stephen P

AU - Withers, David J

AU - Wood, Claire J

AU - Conci, Elena

AU - Clements, Dylan N

AU - Summers, Kim M

AU - German, Alexander J

AU - Mellersh, Cathryn S

AU - Arendt, Maja L

AU - Iyemere, Valentine P

AU - Withers, Elaine

AU - Söder, Josefin

AU - Wernersson, Sara

AU - Andersson, Göran

AU - Lindblad-Toh, Kerstin

AU - Yeo, Giles S H

AU - O'Rahilly, Stephen

PY - 2016/5/10

Y1 - 2016/5/10

N2 - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

AB - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

KW - Adiposity/genetics

KW - Amino Acid Sequence

KW - Animals

KW - Appetite/genetics

KW - Base Pairing

KW - Base Sequence

KW - Body Weight/genetics

KW - COS Cells

KW - Cercopithecus aethiops

KW - Dogs

KW - Feeding Behavior

KW - Gene Deletion

KW - Genotype

KW - Obesity/genetics

KW - Pro-Opiomelanocortin/chemistry

KW - Receptors, Melanocortin/metabolism

KW - beta-MSH/metabolism

U2 - 10.1016/j.cmet.2016.04.012

DO - 10.1016/j.cmet.2016.04.012

M3 - Journal article

C2 - 27157046

SN - 1550-4131

VL - 23

SP - 893

EP - 900

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

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