A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

Rahul Tyagi; Bharat Shimpukade; Stefanie Blättermann; Evi Kostenis; Trond Ulven

A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

Rahul Tyagi, Bharat Shimpukade, Stefanie Blättermann, Evi Kostenis, Trond Ulven

8 Citations (Scopus)

Abstract

A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions

Original language	English
Journal	MedChemComm
Volume	3
Pages (from-to)	195-198
Number of pages	4
ISSN	2040-2503
Publication status	Published - Feb 2012

Keywords

inflammatory mediator
5-oxo-ETE

Cite this

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title = "A concise synthesis of the potent inflammatory mediator 5-oxo-ETE",

abstract = "A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions",

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AU - Tyagi, Rahul

AU - Shimpukade, Bharat

AU - Blättermann, Stefanie

AU - Kostenis, Evi

AU - Ulven, Trond

PY - 2012/2

Y1 - 2012/2

N2 - A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions

AB - A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions

KW - inflammatory mediator

KW - 5-oxo-ETE

M3 - Journal article

SN - 2040-2503

VL - 3

SP - 195

EP - 198

JO - MedChemComm

JF - MedChemComm

ER -

A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

Abstract

Keywords

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