Abstract
The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.
| Original language | English |
|---|---|
| Journal | International Journal of Peptide and Protein Research |
| Volume | 32 |
| Issue number | 5 |
| Pages (from-to) | 331-43 |
| Number of pages | 13 |
| ISSN | 0367-8377 |
| Publication status | Published - Nov 1988 |
Keywords
- Acridines/chemical synthesis
- Amino Acid Sequence
- Chemical Phenomena
- Chemistry
- DNA/drug effects
- Molecular Sequence Data
- Molecular Structure
- Nitrobenzenes/chemical synthesis
- Peptides/chemical synthesis
- Photochemistry
- Sulfones/chemical synthesis