1,2,3-triazolyl amino acids as AMPA receptor ligands

Nathan J. Stanley; Daniel Sejer Pedersen; Birgitte Nielsen; Trine Kvist; Jesper M Mathiesen; Hans Bräuner-Osborne; Dennis K Taylor; Andrew D Abell

doi:10.1016/j.bmcl.2010.09.139

1,2,3-triazolyl amino acids as AMPA receptor ligands

Nathan J. Stanley, Daniel Sejer Pedersen, Birgitte Nielsen, Trine Kvist, Jesper M Mathiesen, Hans Bräuner-Osborne, Dennis K Taylor, Andrew D Abell

30 Citations (Scopus)

Abstract

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

Original language	English
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	20
Issue number	24
Pages (from-to)	7512-7515
ISSN	0960-894X
DOIs	https://doi.org/10.1016/j.bmcl.2010.09.139
Publication status	Published - 15 Dec 2010

Keywords

Former Faculty of Pharmaceutical Sciences

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10.1016/j.bmcl.2010.09.139

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title = "1,2,3-triazolyl amino acids as AMPA receptor ligands",

abstract = "The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Stanley, {Nathan J.} and Pedersen, {Daniel Sejer} and Birgitte Nielsen and Trine Kvist and Mathiesen, {Jesper M} and Hans Br{\"a}uner-Osborne and Taylor, {Dennis K} and Abell, {Andrew D}",

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AU - Stanley, Nathan J.

AU - Pedersen, Daniel Sejer

AU - Nielsen, Birgitte

AU - Kvist, Trine

AU - Mathiesen, Jesper M

AU - Bräuner-Osborne, Hans

AU - Taylor, Dennis K

AU - Abell, Andrew D

N1 - Keywords: synthesis; glutamate receptor; triazole

PY - 2010/12/15

Y1 - 2010/12/15

N2 - The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

AB - The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.bmcl.2010.09.139

DO - 10.1016/j.bmcl.2010.09.139

M3 - Journal article

C2 - 21036612

SN - 0960-894X

VL - 20

SP - 7512

EP - 7515

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 24

ER -

1,2,3-triazolyl amino acids as AMPA receptor ligands

Abstract

Keywords

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