γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

Lucia Tamborini; Veronica Nicosia; Paola Conti; Federica Dall'Oglio; Carlo De Micheli; Birgitte Nielsen; Anders A. Jensen; Darryl S Pickering; Andrea Pinto

doi:10.1016/j.tet.2016.11.025

γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

Lucia Tamborini, Veronica Nicosia, Paola Conti, Federica Dall'Oglio, Carlo De Micheli, Birgitte Nielsen, Anders A. Jensen, Darryl S Pickering, Andrea Pinto

1 Citation (Scopus)

Abstract

γ-Glutamyl-dipeptides, built by condensing the distal carboxylate of L-Glu (or D-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereoelectronic properties of iGluRs, searching for subtype-selective ligands.

Original language	English
Journal	Tetrahedron
Volume	72
Issue number	51
Pages (from-to)	8586-8492
Number of pages	7
ISSN	0040-4020
DOIs	https://doi.org/10.1016/j.tet.2016.11.025
Publication status	Published - 1 Dec 2016

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title = "γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket",

abstract = "γ-Glutamyl-dipeptides, built by condensing the distal carboxylate of L-Glu (or D-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereoelectronic properties of iGluRs, searching for subtype-selective ligands.",

author = "Lucia Tamborini and Veronica Nicosia and Paola Conti and Federica Dall'Oglio and {De Micheli}, Carlo and Birgitte Nielsen and Jensen, {Anders A.} and Pickering, {Darryl S} and Andrea Pinto",

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doi = "10.1016/j.tet.2016.11.025",

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T1 - γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

AU - Tamborini, Lucia

AU - Nicosia, Veronica

AU - Conti, Paola

AU - Dall'Oglio, Federica

AU - De Micheli, Carlo

AU - Nielsen, Birgitte

AU - Jensen, Anders A.

AU - Pickering, Darryl S

AU - Pinto, Andrea

PY - 2016/12/1

Y1 - 2016/12/1

N2 - γ-Glutamyl-dipeptides, built by condensing the distal carboxylate of L-Glu (or D-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereoelectronic properties of iGluRs, searching for subtype-selective ligands.

AB - γ-Glutamyl-dipeptides, built by condensing the distal carboxylate of L-Glu (or D-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereoelectronic properties of iGluRs, searching for subtype-selective ligands.

U2 - 10.1016/j.tet.2016.11.025

DO - 10.1016/j.tet.2016.11.025

M3 - Journal article

SN - 0040-4020

VL - 72

SP - 8586

EP - 8492

JO - Tetrahedron

JF - Tetrahedron

IS - 51

ER -

γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

Abstract

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