Publikationer pr. år
Publikationer pr. år
Personlig profil
Primære forskningsområder
Ionotropic receptors for inhibitory amino acids (GABA, glycine) with emphasis on the relation to epilepsyAktuel forskning
Ionotropic receptors for inhibitory amino acids (GABA, glycine) with emphasis on the relation to epilepsy. The mechanism of activation of the receptors and structure-activity relationships of the ligands are studied in cultured neurons or in cell lines expressing recombinant wild type or mutant receptors using patch-clamp electrophysiology. Inhibition of neuronal activity is studied in vitro (electrophysiology in brain slices) and in vivo in the PTZ kindling model of epilepsy, where both the anticonvulsive and antiepileptogenic effects can be investigated. Using these metods, a current main theme of our research is to investigate whether selective ligands for extrasynaptic GABAA receptors are potential antiepileptic drugs.Undervisnings- og vejledningsområder
General physiology. Neurophysiology and -pharmacology. Biological standardization. Pharmacodynamics. Ion channel kinetics.Emneord
- Det tidligere Farmaceutiske Fakultet
- elektrofysiologi
- GABA
- farmakodynamik
- dyremodeller
- synaptisk transmission
- epilepsi
- ionkanalkinetik
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Uffe Kristiansen er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 6 Lignende profiler
Publikation
-
Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)
Leguizamon, C. R. R., Elnagar, M., Kristiansen, U. & Kohlmeier, K. A., 1 dec. 2019, I: Scientific Reports. s. 1 - 11 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
4 Citationer (Scopus)17 Downloads (Pure) -
The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice
von Schoubye, N. L., Frederiksen, K., Kristiansen, U., Petersen, A. V., Dalby, N. O., Grunnet, M., Jensen, H. S., Jespersen, T., Sohal, V. S. & Perrier, J-F., 1 jan. 2018, I: Neuroscience Letters. 662, s. 29-35 7 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells
Simonsen, C., Boddum, K., von Schoubye, N. L., Kloppenburg, A., Sønderskov, K., Hansen, S. L. & Kristiansen, U., aug. 2017, I: Pharmacology Research & Perspectives. 5, 4, 15 s., e00322.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Astrocytic GABA transporter activity modulates excitatory neurotransmission
Boddum, K., Jensen, T. P., Magloire, V., Kristiansen, U., Rusakov, D. A., Pavlov, I. & Walker, M. C., 25 nov. 2016, I: Nature Communications. 7, 10 s., 13572.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors
Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, U., Frølund, B., Frederiksen, K. & Jensen, A. A., 15 jun. 2016, I: Biochemical Pharmacology. 110-111, s. 92-108 17 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Uterine contraction induced by Ghanaian plants used to induce abortion
Larsen, B. HV., Soelberg, J., Kristiansen, U. & Jäger, A. K., 1 sep. 2016, I: South African Journal of Botany. 106, s. 137-39 3 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology
Krall, J., Balle, T., Krogsgaard-Larsen, N., Sørensen, T. E., Krogsgaard-Larsen, P., Kristiansen, U. & Frølund, B., 2015, Diversity and functions of GABA receptors: A tribute to Hanns Möhler, Part A. Bind 72. s. 201-27 27 s. (Advances in Pharmacology).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review
-
Hippocampal P3-Like Auditory Event-Related Potentials are Disrupted in a Rat Model of Cholinergic Degeneration in Alzheimer's Disease: Reversal by Donepezil Treatment: Reversal by Donepezil Treatment
Laursen, B., Mørk, A., Kristiansen, U. & Bastlund, J. F., 2 jul. 2014, I: Journal of Alzheimer's Disease. 42, 4, s. 1179–1189 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Aktiviteter
- 1 Medlemskab af forskningsnetværk
-
Biologue (Ekstern organisation)
Uffe Kristiansen (Medlem)
10 maj 2006 → …Aktivitet: Medlemsskab - typer › Medlemskab af forskningsnetværk