Ragnar Thomsen

Research output

Research output per year 2012 2017 2019 2019

• 12 Journal article
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2019

  Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1

  Briand, E., Thomsen, R., Linnet, K., Rasmussen, H. B., Brunak, S. & Taboureau, O., 29 Jul 2019, In: Molecules. 24, 15, 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human CES1 protein 100%
  • Carboxylesterase 70%
  • machine learning 66%
  • Machine Learning 59%
  • drugs 52%
  1 Citation (Scopus)

  26 Downloads (Pure)

• Coronary artery CT calcium score assessed by direct calcium quantification using atomic absorption spectroscopy and compared to macroscopic and histological assessments

  Gheorghe, A. G., Jacobsen, C., Thomsen, R., Linnet, K., Lynnerup, N., Andersen, C. B., Fuchs, A., Kofoed, K. F. & Banner, J., 1 Sept 2019, In: International Journal of Legal Medicine. 133, 5, p. 1485–1496

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Spectrum Analysis 100%
  • Coronary Vessels 83%
  • Calcium 69%
  • Pathologic Constriction 34%
  • Coronary Stenosis 16%
  4 Citations (Scopus)

• The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid/methylphenidate ratios

  Stage, C., Dalhoff, K., Rasmussen, H. B., Schow Guski, L., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., Busk Madsen, M. & Jürgens, G., 1 Jul 2019, In: Basic & Clinical Pharmacology & Toxicology. 125, 1, p. 54-61

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ritalinic acid 100%
  • Ritalinic Acid 92%
  • Methylphenidate 79%
  • Genetic Variation 47%
  • Single Nucleotide Polymorphism 41%
  2 Citations (Scopus)
• 2018

  Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

  Kaddurah-Daouk, R., Hankemeier, T., Scholl, E. H., Baillie, R., Harms, A., Stage, C., Dalhoff, K. P., Jűrgens, G., Taboureau, O., Nzabonimpa, G. S., Motsinger-Reif, A. A., Thomsen, R., Linnet, K., Rasmussen, H. B., INDICES Consortium & Pharmacometabolomics Research Network, 1 Aug 2018, In: CPT: Pharmacometrics and Systems Pharmacology. 7, 8, p. 525-533 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lipids 100%
  • Pharmacokinetics 95%
  • Carboxylesterase 90%
  • Methylphenidate 84%
  • Drugs 69%
  5 Citations (Scopus)
• 2017

  Advantages of analyzing postmortem brain samples in routine forensic drug screening—case series of three non-natural deaths tested positive for lysergic acid diethylamide (LSD)

  Mardal, M., Johansen, S. S., Thomsen, R. & Linnet, K., Sept 2017, In: Forensic Science International. 278, p. e14-e18

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lysergic Acid Diethylamide 100%
  • brain 63%
  • death 54%
  • drug 51%
  • Brain 37%
  3 Citations (Scopus)

• Nomenclature for alleles of the human carboxylesterase 1 gene

  INDICES Consortium, 1 Jan 2017, In: Pharmacogenetics and Genomics. 27, 2, p. 78-80 3 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  4 Citations (Scopus)

• Postmortem concentrations of gamma-hydroxybutyrate (GHB) in peripheral blood and brain tissue - Differentiating between postmortem formation and antemortem intake

  Thomsen, R., Rasmussen, B. S., Johansen, S. S. & Linnet, K., 1 Mar 2017, In: Forensic Science International. 272, p. 154-158

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sodium Oxybate 100%
  • brain 56%
  • Brain 32%
  • drug 18%
  • intoxication 16%
  10 Citations (Scopus)

• The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects

  Stage, C., Jürgens, G., Guski, L. S., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., Lyauk, Y. K., Berg Rasmussen, H., Dalhoff, K. & INDICES Consortium, Jul 2017, In: British Journal of Clinical Pharmacology. 83, 7, p. 1506–1514

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Methylphenidate 100%
  • Pharmacokinetics 60%
  • Genotype 57%
  • Healthy Volunteers 53%
  • Area Under Curve 49%
  15 Citations (Scopus)

• The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers

  Stage, C., Jürgens, G., Guski, L. S., Thomsen, R., Bjerre, D., Ferrero-Miliani, L., Lyauk, Y. K., Berg Rasmussen, H., Dalhoff, K. & INDICES Consortium, 6 Dec 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 6, p. 487–492

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Enalapril 100%
  • Carboxylesterase 84%
  • Pharmacokinetics 47%
  • Genotype 45%
  • Healthy Volunteers 42%
  10 Citations (Scopus)
• 2016

  Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants

  Lyauk, Y. K., Stage, C., Bergmann, T. K., Ferrero, L., Bjerre, D., Thomsen, R., Dalhoff, K. P., Rasmussen, H. B. & Jürgens, G., 1 Dec 2016, In: Clinical and Translational Science. 9, 6, p. 337–345

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Methylphenidate 100%
  • Carboxylesterase 82%
  • Pharmacokinetics 46%
  • Plasma Concentration 35%
  • Safety 26%
  4 Citations (Scopus)

  84 Downloads (Pure)
• 2015

  Synthetic cannabimimetic agents metabolized by carboxylesterases

  Thomsen, R., Nielsen, L. M., Holm, N. B., Rasmussen, H. B., Linnet, K. & INDICES Consortium, 1 Jul 2015, In: Drug Testing and Analysis. 7, 7, p. 565-76 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Carboxylic Ester Hydrolases 100%
  • N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide 89%
  • AB-FUBINACA 86%
  • Synthetic Cannabinoid 60%
  • enzyme 49%
  61 Citations (Scopus)
• 2014

  In Vitro Drug Metabolism by Human Carboxylesterase 1: Focus on Angiotensin-Converting Enzyme Inhibitors

  Thomsen, R., Rasmussen, H. B., Linnet, K. & INDICES Consortium, Jan 2014, In: Drug Metabolism and Disposition. 42, 1, p. 126-33 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human CES1 protein 100%
  • Ramipril 84%
  • Enalapril 82%
  • Trandolapril 76%
  • Angiotensin-Converting Enzyme Inhibitor 72%
  63 Citations (Scopus)
• 2012

  Enantioselective Determination of Methylphenidate and Ritalinic Acid in Whole Blood from Forensic Cases Using Automated Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry

  Thomsen, R., Rasmussen, H. B., Linnet, K. & the INDICES Consortium, 1 Oct 2012, In: Journal of Analytical Toxicology. 36, 8, p. 560-568 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ritalinic acid 100%
  • Ritalinic Acid 92%
  • Methylphenidate 79%
  • Liquid chromatography 74%
  • Solid Phase Extraction 69%
  16 Citations (Scopus)