Ole Østergaard

Research output

Research output per year 2002 2004 2007 2011 2012 2013 2014 2015 2016 2017 2018

• 27 Journal article
• 3 Review

Research output per year

Research output per year

Search results

• 2018

  Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

  Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J-M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C., & 31 othersBedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M. Á., Brigstock, D. R., Brisson, A., Broekman, M. L., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Jørgensen, M. M., Jacobsen, S., Nejsum, P., Østergaard, O. & Xu, J., 1 Jan 2018, In: Journal of Extracellular Vesicles. 7, 1, p. 1-47 1535750.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Extracellular Vesicles 100%
  • Guidelines 54%
  • Exosomes 22%
  • Cell-Derived Microparticles 15%
  • Checklist 9%
  1914 Citations (Scopus)

  75 Downloads (Pure)
• 2017

  A review of studies of the proteomes of circulating microparticles: Key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus

  Nielsen, C. T., Østergaard, O., Rasmussen, N. S., Jacobsen, S. & Heegaard, N. H. H., 2017, In: Clinical Proteomics. 14, 24 p., 11.

  Research output: Contribution to journal › Review › peer-review

  • Galectin 3 100%
  • Proteome 78%
  • Vascular Diseases 73%
  • Systemic Lupus Erythematosus 71%
  • Carrier Proteins 64%
  15 Citations (Scopus)

  49 Downloads (Pure)

• Biophysical comparison of diphtheria and tetanus toxins with the formaldehyde-detoxified toxoids, the main components of diphtheria and tetanus vaccines

  Alsarraf, H., Dedic, E., Bjerrum, M. J., Østergaard, O., Kristensen, M. P., Petersen, J. W. & Jørgensen, R., 17 Nov 2017, In: Virulence. 8, 8, p. 1880-1889 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  6 Citations (Scopus)

• Distinct proteome pathology of circulating microparticles in systemic lupus erythematosus

  Østergaard, O., Nielsen, C. T., Tanassi, J. T., Iversen, L. V., Jacobsen, S. & Heegaard, N. H. H., 21 Jun 2017, In: Clinical Proteomics. 14, 13 p., 23.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteome 100%
  • Systemic Lupus Erythematosus 90%
  • Pathology 60%
  • Protein 39%
  • Systemic Scleroderma 36%
  14 Citations (Scopus)

  156 Downloads (Pure)

• Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions

  Loke, I., Østergaard, O., Heegaard, N. H. H., Packer, N. H. & Thaysen-Andersen, M., Aug 2017, In: Molecular and Cellular Proteomics. 16, 8, p. 1507-1527 21 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human ELANE protein 100%
  • N-Glycan 80%
  • Glycosylation 65%
  • Bacteriostatic 21%
  • Inhibition of Growth 20%
  27 Citations (Scopus)
• 2016

  A Novel Fic (Filamentation Induced by cAMP) Protein from Clostridium difficile Reveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism

  Dedic, E., Alsarraf, H., Welner, D. H., Østergaard, O., Klychnikov, O. I., Hensbergen, P. J., Corver, J., van Leeuwen, H. C. & Jørgensen, R., 17 Jun 2016, In: The Journal of Biological Chemistry. 291, 25, p. 13286-13300 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clostridium difficile 100%
  • Protein Domains 84%
  • Adenosine Triphosphate 37%
  • Protein 34%
  • Proteins 30%
  6 Citations (Scopus)

• Quantitative Protein Profiling of Chlamydia trachomatis Growth Forms Reveals Defense Strategies Against Tryptophan Starvation

  Østergaard, O., Follmann, F., Olsen, A. W., Heegaard, N. H., Andersen, P. & Rosenkrands, I., Dec 2016, In: Molecular and Cellular Proteomics. 15, 12, p. 3540-3550 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chlamydia trachomatis 100%
  • Starvation 94%
  • Tryptophan 92%
  • Growth 43%
  • Protein 35%
  7 Citations (Scopus)
• 2015

  Cross-sectional study of soluble selectins, fractions of circulating microparticles and their relationship to lung and skin involvement in systemic sclerosis

  Iversen, L. V., Ullman, S., Østergaard, O., Nielsen, C. T., Halberg, P., Karlsmark, T., Heegaard, N. H. H. & Jacobsen, S., 12 Aug 2015, In: BMC Musculoskeletal Disorders. 16, 9 p., 191.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Selectins 100%
  • Systemic Scleroderma 87%
  • Annexin A5 68%
  • Vital Capacity 50%
  • Cross-Sectional Studies 50%
  12 Citations (Scopus)

• Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis

  Nielsen, C. T., Østergaard, O., Rekvig, O. P., Sturfelt, G., Jacobsen, S. & Heegaard, N. H. H., 11 Oct 2015, In: Lupus. 24, 11, p. 1150-60

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Galectin 3 100%
  • Lupus Nephritis 92%
  • Carrier Proteins 64%
  • Electrons 60%
  • Systemic Lupus Erythematosus 33%
  38 Citations (Scopus)

• Impact of microRNA-130a on the neutrophil proteome

  Pedersen, C. C., Refsgaard, J. C., Østergaard, O., Jensen, L. J., Heegaard, N. H. H., Borregaard, N. & Cowland, J. B., 25 Nov 2015, In: B M C Immunology. 16, 10 p., 70.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteome 100%
  • MicroRNAs 80%
  • Neutrophils 75%
  • Proteins 35%
  • Clone Cells 20%
  7 Citations (Scopus)

• Important options available--from start to finish--for translating proteomics results to clinical chemistry

  Heegaard, N. H. H., Østergaard, O., Bahl, J. M. C., Overgaard, M., Beck, H. C., Rasmussen, L. M. & Larsen, M. R., 1 Feb 2015, In: Proteomics - Clinical Applications. 9, 1-2, p. 235-52 18 p.

  Research output: Contribution to journal › Review › peer-review

  • Clinical Chemistry 100%
  • Proteomics 71%
  • Chemistry 44%
  • Application 12%
  • Clinical Studies 10%
  7 Citations (Scopus)
• 2014

  Filaggrin is a predominant member of the denaturation-resistant nickel-binding proteome of human epidermis

  Ross-Hansen, K., Østergaard, O., Tanassi, J. T., Thyssen, J. P., Johansen, J. D., Menné, T. & Heegaard, N. H. H., Apr 2014, In: The Journal of Investigative Dermatology. 134, 4, p. 1164-1166 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  26 Citations (Scopus)

• Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

  Sørensen, O. E., Clemmensen, S. N., Dahl, S. L., Østergaard, O., Heegaard, N. H. H., Glenthøj, A., Nielsen, F. C. & Borregaard, N., 1 Oct 2014, In: The Journal of Clinical Investigation. 124, 10, p. 4539-48 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cathepsin C 100%
  • Serine Proteases 82%
  • Neutrophils 57%
  • CAP18 lipopolysaccharide-binding protein 52%
  • Peptide Hydrolases 20%
  104 Citations (Scopus)

• Plasma levels of galectin-3-binding protein reflect type I interferon activity and are increased in patients with systemic lupus erythematosus

  Nielsen, C. T., Lood, C., Østergaard, O., Iversen, L. V., Voss, A., Bengtsson, A., Jacobsen, S. & Heegaard, N. H. H., 1 Jun 2014, In: Lupus Now. 1, p. 1-8 8 p., e000026.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Galectin 3 100%
  • Interferon Type I 90%
  • Systemic Lupus Erythematosus 71%
  • Carrier Proteins 64%
  • Sweden 21%
  23 Citations (Scopus)

• Protein expression, characterization, crystallization and preliminary X-ray crystallographic analysis of a Fic protein from Clostridium difficile

  Welner, D., Dedic, E., van Leeuwen, H. C., Kuijper, E., Bjerrum, M. J., Østergaard, O. & Jørgensen, R., Jun 2014, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 70, p. 827-831 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clostridium 100%
  • Crystallization 72%
  • Clostridium difficile 71%
  • bacteria 64%
  • virulence 52%
  4 Citations (Scopus)
• 2013

  A heparin-based method for flow cytometric analysis of microparticles directly from platelet-poor plasma in calcium containing buffer

  Iversen, L. V., Ostergaard, O., Nielsen, C., Jacobsen, S. & Heegaard, N. H. H., 28 Feb 2013, In: Journal of Immunological Methods. 388, 1-2, p. 49-59 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Buffers 100%
  • Heparin 98%
  • Blood Platelets 84%
  • Calcium 74%
  • Flow Cytometry 15%
  19 Citations (Scopus)

• Circulating microparticles and plasma levels of soluble E- and P-selectins in patients with systemic sclerosis

  Iversen, L., Østergaard, O., Ullman, S., Nielsen, C. T., Halberg, P., Karlsmark, T., Heegaard, N. H. H. & Jacobsen, S., 2013, In: Scandinavian Journal of Rheumatology. 42, 6, p. 473-482 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • E-Selectin 100%
  • P-Selectin 99%
  • Systemic Scleroderma 94%
  • Annexin A5 51%
  • Selectins 23%
  18 Citations (Scopus)

• Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

  Rørvig, S., Østergaard, O., Heegaard, N. H. H. & Borregaard, N., Oct 2013, In: Journal of Leukocyte Biology. 94, 4, p. 711-721 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Secretory Vesicles 100%
  • Proteome 91%
  • Gene Expression Profiling 90%
  • Neutrophils 68%
  • Cell Membrane 63%
  133 Citations (Scopus)

• Unique Protein Signature of Circulating Microparticles in Systemic Lupus Erythematosus

  Østergaard, O., Nielsen, C., Iversen, L. V., Tanassi, J. T., Knudsen, S., Jacobsen, S. & Heegaard, N. H. H., Oct 2013, In: Arthritis & Rheumatism. 65, 10, p. 2680-2690 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Systemic Lupus Erythematosus 100%
  • Proteins 39%
  • 14-3-3 Proteins 32%
  • Systemic Scleroderma 26%
  • Rheumatoid Arthritis 19%
  73 Citations (Scopus)
• 2012

  Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

  Nielsen, C. T., Østergaard, O., Stener, L., Iversen, L. V., Truedsson, L., Gullstrand, B., Jacobsen, S. & Heegaard, N. H. H., Apr 2012, In: Arthritis & Rheumatism. 64, 4, p. 1227-36 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell-Derived Microparticles 100%
  • Complement Activation 70%
  • Systemic Lupus Erythematosus 58%
  • Autoantibodies 57%
  • Immunoglobulin G 46%
  125 Citations (Scopus)

• Quantitative proteome profiling of normal human circulating microparticles

  Østergaard, O., Nielsen, C. T., Iversen, L. V., Jacobsen, S., Tanassi, J. T. & Heegaard, N. H. H., 6 Apr 2012, In: Journal of Proteome Research. 11, 4, p. 2154-63 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteome 100%
  • Cytoskeletal Proteins 38%
  • Flow Cytometry 24%
  • Data Analysis 23%
  • Protein 23%
  37 Citations (Scopus)
• 2011

  Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis

  Clemmensen, S. N., Jacobsen, L. C., Rørvig, S., Askaa, B., Christenson, K., Iversen, M., Jørgensen, M. H., Larsen, M. T., van Deurs, B., Østergaard, O., Heegaard, N. H., Cowland, J. B. & Borregaard, N., 1 Jun 2011, In: European Journal of Haematology. 86, 6, p. 517-30 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • alpha 1-Antitrypsin 100%
  • Exocytosis 84%
  • Granulocytes 75%
  • Neutrophils 59%
  • Protease Inhibitors 14%
  42 Citations (Scopus)

• Distinct features of circulating microparticles and their relationship to clinical manifestations in systemic lupus erythematosus

  Nielsen, C. T., Østergaard, O., Johnsen, C., Jacobsen, S. & Heegaard, N. H. H., Oct 2011, In: Arthritis & Rheumatism. 63, 10, p. 3067-77 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Annexin A5 100%
  • Systemic Lupus Erythematosus 83%
  • Cell-Derived Microparticles 39%
  • Endothelial Cells 18%
  • Leukocytes 12%
  92 Citations (Scopus)
• 2009

  Integration of the barley genetic and seed proteome maps for chromosome 1H, 2H, 3H, 5H and 7H

  Finnie, C., Bagge, M., Steenholdt, T., Østergaard, O., Bak-Jensen, K. S., Backes, G. M., Jensen, A., Giese, N. H., Larsen, J., Roepstorff, P. & Svensson, B., 2009, In: Functional & Integrative Genomics. 9, 1, p. 135-143 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  14 Citations (Scopus)
• 2007

  Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis

  Giorgetti, S., Stoppini, M., Tennent, G. A., Relini, A., Marchese, L., Raimondi, S., Monti, M., Marini, S., Østergaard, O., Heegaard, N. H. H., Pucci, P., Esposito, G., Merlini, G. & Bellotti, V., Feb 2007, In: Protein Science. 16, 2, p. 343-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid Fibril 100%
  • Two Dimensional Polyacrylamide Gel Electrophoresis 99%
  • Amyloidosis 94%
  • Lysine 82%
  • Electrophoresis 80%
  20 Citations (Scopus)

• Spatio-temporal profiling and degradation of alpha-amylase isozymes during barley seed germination

  Bak-Jensen, K. S., Laugesen, S., Ostergaard, O., Finnie, C., Roepstorff, P. & Svensson, B., May 2007, In: F E B S Journal. 274, 10, p. 2552-65 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Germination 100%
  • Hordeum 98%
  • alpha-Amylases 91%
  • Seeds 71%
  • Isoenzymes 69%
  39 Citations (Scopus)
• 2004

  Aspects of the barley seed proteome during development and germination

  Finnie, C., Maeda, K., ØStergaard, O., Bak-Jensen, K. S., Larsen, J. & Svensson, B., Jun 2004, In: Biochemical Society Transactions. 32, Pt3, p. 517-9 3 p.

  Research output: Contribution to journal › Review › peer-review

  • Germination 100%
  • Hordeum 98%
  • Proteome 72%
  • Seeds 71%
  • Protein 28%
  57 Citations (Scopus)

• Proteome analysis of barley seeds: Identification of major proteins from two-dimensional gels (pI 4-7)

  Østergaard, O., Finnie, C. S., Laugesen, S., Roepstorff, P. & Svensson, B., 2004, In: Proteomics. 4, p. 2437-2447 11 p., https://doi.org/10.1002/pmic.200300753.

  Research output: Contribution to journal › Journal article › Research › peer-review

  115 Citations (Scopus)
• 2003

  Identification, cloning and characterization of two thioredoxin h isoforms, HvTrxh1 and HvTrxh2, from the barley seed proteome

  Maeda, K., Finnie, C., ØStergaard, O. & Svensson, B., Jun 2003, In: European Journal of Biochemistry. 270, 12, p. 2633-43 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Thioredoxin h 100%
  • Hordeum 62%
  • Thioredoxin 55%
  • Proteome 45%
  • Seeds 44%
  50 Citations (Scopus)
• 2002

  Initial proteome analysis of mature barley seeds and malt

  Østergaard, O., Melchior, S., Roepstorff, P. & Svensson, B., Jun 2002, In: Proteomics. 2, 6, p. 733-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hordeum 100%
  • Proteome 73%
  • Seeds 72%
  • Protein 29%
  • alpha-Amylases 26%
  91 Citations (Scopus)