Mikkel-Ole Skjødt

2018

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Hertz, C. E., Bayarri-Olmos, R., Kirketerp-Møller, N., van Putten, S., Pilely, K., Skjoedt, M.-O. & Garred, P., 28 Aug 2018, In: Frontiers in Immunology. 9, 13 p., 1945.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

36 Downloads (Pure)

Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)

Bayarri-Olmos, R., Kirketerp-Moller, N., Pérez-Alós, L., Skjodt, K., Skjoedt, M. O. & Garred, P., 28 Sept 2018, In: Frontiers in Immunology. 9, 14 p., 2238.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

28 Downloads (Pure)

2017

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques

Pilely, K., Fumagalli, S., Rosbjerg, A., Genster, N., Skjoedt, M.-O., Perego, C., Ferrante, A. M. R., De Simoni, M.-G. & Garred, P., 29 Aug 2017, In: Frontiers in Immunology. 8, 14 p., 1040.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

110 Downloads (Pure)

2016

Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury

Ozaki, M., Kang, Y., Tan, Y. S., Pavlov, V. I., Liu, B., Boyle, D. C., Kushak, R. I., Skjoedt, M.-O., Grabowski, E. F., Taira, Y. & Stahl, G. L., 1 Oct 2016, In: Kidney International. 90, 4, p. 774-782 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation

Kozarcanin, H., Lood, C., Fog, L. M., Sandholm, K., Hamad, O. A., Bengtsson, A. A., Skjoedt, M.-O., Huber-Lang, M., Garred, P., Ekdahl, K. N. & Nilsson, B., 1 Mar 2016, In: Journal of Thrombosis and Haemostasis. 14, 3, p. 531-545 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

57 Citations (Scopus)

2015

Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus

Hein, E., Nielsen, L. A., Nielsen, C. T., Munthe-Fog, L., Skjødt, M.-O., Jacobsen, S. & Garred, P., 1 Feb 2015, In: Molecular Immunology. 63, 2, p. 209-214 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways

Nordmaj, M. A., Munthe-Fog, L., Hein, E., Skjoedt, M.-O. & Garred, P., 1 Dec 2015, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29, 12, p. 4945-55 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency

Bay, J. T., Katzenstein, T. L., Kofoed, K., Patel, D., Skjødt, M.-O., Garred, P. & Schejbel, L., 1 Oct 2015, In: Clinical Immunology. 160, 2, p. 315-8 4 p.

Research output: Contribution to journal › Letter › peer-review

5 Citations (Scopus)

Pentraxin-3 level at admission is a strong predictor of short-term mortality in a community-based hospital setting

Bastrup-Birk, S., Munthe-Fog, L., Skjødt, M.-O., Ma, Y. J., Nielsen, H., Køber, L., Nielsen, O. W., Iversen, K. & Garred, P., 1 May 2015, In: Journal of Internal Medicine. 277, 5, p. 562-572 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway

Ma, Y. J., Hein, E., Munthe-Fog, L., Skjødt, M.-O., Bayarri-Olmos, R., Romani, L. & Garred, P., 1 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3365-73 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema

Hansen, C. B., Csuka, D., Munthe-Fog, L., Varga, L., Farkas, H., Hansen, K. M., Koch, C., Skjødt, K., Garred, P. & Skjødt, M.-O., 15 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 8, p. 3596-604 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

2014

A specific assay for quantification of human C4c by use of an anti-C4c monoclonal antibody

Pilely, K., Skjoedt, M.-O., Nielsen, C., Andersen, T. E., Louise Aabom, A., Vitved, L., Koch, C., Skjødt, K. & Palarasah, Y., Mar 2014, In: Journal of Immunological Methods. 405, p. 87-96 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Defining the complement biomarker profile of C3 glomerulopathy

Zhang, Y., Nester, C. M., Martin, B., Skjoedt, M.-O., Meyer, N. C., Shao, D., Borsa, N., Palarasah, Y. & Smith, R. J. H., 2014, In: Clinical Journal of American Society of Nephrology. . 9, 11, p. 1876-82 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

Heterocomplex Formation between MBL/Ficolin/CL-11–Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11–Associated Protein-1

Rosbjerg, A., Munthe-Fog, L., Garred, P. & Skjoedt, M.-O., 1 May 2014, In: Journal of immunology (Baltimore, Md. : 1950). 192, 9, p. 4352-60 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

2013

A novel assay to quantitate MASP-2/ficolin-3 complexes in serum

Csuka, D., Munthe-Fog, L., Skjoedt, M.-O., Hein, E., Bay, J. T., Varga, L., Füst, G. & Garred, P., 31 Jan 2013, In: Journal of Immunological Methods. 387, 1-2, p. 237-44 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study

Schoos, M. M., Munthe-Fog, L., Skjoedt, M.-O., Ripa, R. S., Lønborg, J., Kastrup, J., Kelbæk, H., Clemmensen, P. & Garred, P., Jul 2013, In: Molecular Immunology. 54, 3-4, p. 408-14 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure

Prohászka, Z., Munthe-Fog, L., Ueland, T., Gombos, T., Yndestad, A., Förhécz, Z., Skjoedt, M.-O., Pozsonyi, Z., Gustavsen, A., Jánoskuti, L., Karádi, I., Gullestad, L., Dahl, C. P., Askevold, E. T., Füst, G., Aukrust, P., Mollnes, T. E. & Garred, P., 15 Apr 2013, In: P L o S One. 8, 4, p. 1-9 9 p., e60976.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex

Ma, Y. J., Skjoedt, M.-O. & Garred, P., Apr 2013, In: Journal of Innate Immunity. 5, 3, p. 242-250 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

86 Citations (Scopus)

Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome

Bastrup-Birk, S., Skjoedt, M.-O., Munthe-Fog, L., Strom, J. J., Ma, Y. J. & Garred, P., 9 Sept 2013, In: P L o S One. 8, 9, p. 1-9 9 p., e73119.

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency

Csuka, D., Munthe-Fog, L., Skjoedt, M.-O., Kocsis, A., Zotter, Z., Gál, P., Varga, L., Farkas, H., Füst, G. & Garred, P., Jul 2013, In: Molecular Immunology. 54, 3-4, p. 271-277 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2012

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)

Skjoedt, M.-O., Roversi, P., Hummelshoj, T., Palarasah, Y., Rosbjerg, A., Johnson, S., Lea, S. M. & Garred, P., 21 Sept 2012, In: Journal of Biological Chemistry. 287, 39, p. 32913-32921

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis

Pavlov, V. I., Skjoedt, M.-O., Siow Tan, Y., Rosbjerg, A., Garred, P. & Stahl, G. L., 30 Oct 2012, In: Circulation. Supplement. 126, 18, p. 2227-35 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

56 Citations (Scopus)

The interaction pattern of murine serum ficolin-A with microorganisms

Hummelshøj, T., Ma, Y. J., Munthe-Fog, L., Bjarnsholt, T., Moser, C., Skjødt, M.-O., Romani, L., Fujita, T., Endo, Y. & Garred, P., 30 May 2012, In: P L o S One. 7, 5, p. 1-12 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation

Munthe-fog, L., Hummelshoj, T., Honoré, C., Moller, M. E., Skjoedt, M. O., Palsgaard, I., Borregaard, N., Madsen, H. O. & Garred, P., 1 Oct 2012, In: Genes and Immunity. 13, 7, p. 515-522

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

2011

Decreased material-activation of the complement system using low-energy plasma polymerized poly(vinyl pyrrolidone) coatings

Andersen, T. E., Palarasah, Y., Skjødt, M.-O., Ogaki, R., Benter, M., Alei, M., Kolmos, H. J., Koch, C. & Kingshott, P., Jul 2011, In: Biomaterials. 32, 20, p. 4481-8 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

Ma, Y. J., Doni, A., Skjoedt, M.-O., Honore, C., Arendrup, M., Mantovani, A. & Garred, P., 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3405-3417

Research output: Contribution to journal › Journal article › Research › peer-review

89 Citations (Scopus)

Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

Füst, G., Munthe-Fog, L., Illes, Z., Széplaki, G., Molnar, T., Pusch, G., Hirschberg, K., Szegedi, R., Széplaki, Z., Prohászka, Z., Skjoedt, M.-O. & Garred, P., 29 Dec 2011, In: Journal of Neuroinflammation. 8, p. 185

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Novel assays to assess the functional capacity of the classical, the alternative and the lectin pathways of the complement system

Palarasah, Y., Nielsen, C., Sprogøe, U., Christensen, M. L., Lillevang, S., Madsen, H. O., Bygum, A., Koch, C., Skjodt, K. & Skjoedt, M.-O., Jun 2011, In: Clinical and Experimental Immunology. 164, 3, p. 388-95 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Serum concentration and interaction properties of MBL/ficolin associated protein-1

Skjoedt, M.-O., Hummelshoj, T., Palarasah, Y., Hein, E., Munthe-fog, L., Koch, C., Skjodt, K. & Garred, P., 1 May 2011, In: Immunobiology. 216, 5, p. 625-632

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

2010

A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation

Skjoedt, M.-O., Hummelshoj, T., Palarasah, Y., Honore, C., Koch, C., Skjodt, K. & Garred, P., 12 Mar 2010, In: Journal of Biological Chemistry. 285, 11, p. 8234-8243 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

107 Citations (Scopus)

Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity

Hansen, S., Selman, L., Palaniyar, N., Ziegler, K., Brandt, J., Kliem, A., Jonasson, M., Skjoedt, M.-O., Nielsen, O., Hartshorn, K., Jørgensen, T. J. D., Skjødt, K. & Holmskov, U., 15 Nov 2010, In: Journal of immunology (Baltimore, Md. : 1950). 185, 10, p. 6096-104 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

134 Citations (Scopus)

Functional analysis of Ficolin-3 mediated complement activation

Hein, E., Honoré, C., Skjoedt, M.-O., Munthe-Fog, L., Hummelshøj, T. & Garred, P., 10 Nov 2010, In: PloS one. 5, 11, p. e15443

Research output: Contribution to journal › Journal article › Research › peer-review

46 Citations (Scopus)

Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3

Palarasah, Y., Skjodt, K., Brandt, J., Teisner, B., Koch, C., Vitved, L. & Skjoedt, M.-O., 31 Oct 2010, In: Journal of Immunological Methods. 362, 1-2, p. 142-50 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation

Skjoedt, M.-O., Palarasah, Y., Munthe-fog, L., Jie Ma, Y., Weiss, G., Skjodt, K., Koch, C. & Garred, P., 1 Nov 2010, In: Immunobiology. 215, 11, p. 921-931

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Sodium polyanethole sulfonate as an inhibitor of activation of complement function in blood culture systems

Palarasah, Y., Skjoedt, M.-O., Vitved, L., Andersen, T. E., Skjoedt, K. & Koch, C., Mar 2010, In: Journal of Clinical Microbiology. 48, 3, p. 908-14 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

Honore, C., Rorvig, S., Hummelshoj, T., Skjoedt, M.-O., Borregaard, N. & Garred, P., 1 Jul 2010, In: Journal of Leukocyte Biology. 88, 1, p. 145-158

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Two mannose-binding lectin homologues and an MBL-associated serine protease are expressed in the gut epithelia of the urochordate species Ciona intestinalis

Skjoedt, M.-O., Palarasah, Y., Rasmussen, K., Vitved, L., Salomonsen, J., Kliem, A., Hansen, S., Koch, C. & Skjodt, K., 1 Jan 2010, In: Developmental & Comparative Immunology. 34, 1, p. 59-68

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Mikkel-Ole Skjødt

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