Michael Askvad Sørensen

2018

Ribosome Hibernation

Prossliner, T., Winther, K. S., Sørensen, M. A. & Gerdes, K., 23 Nov 2018, In: Annual Review of Genetics. 52, p. 321-348

Research output: Contribution to journal › Review › peer-review

38 Citations (Scopus)

Transfer RNA instability as a stress response in Escherichia coli: rapid dynamics of the tRNA pool as a function of demand

Sørensen, M. A., Fehler, A. O. & Svenningsen, S. L., 4 May 2018, In: RNA Biology. 15, 4/5, p. 586-593 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

62 Downloads (Pure)

2017

Prophages and growth dynamics confound experimental results with antibiotic-tolerant persister cells

Harms, A., Fino, C., Sørensen, M. A., Semsey, S. & Gerdes, K., 12 Dec 2017, In: mBio. 8, 6, 18 p., e01964-17.

Research output: Contribution to journal › Journal article › Research › peer-review

104 Citations (Scopus)

111 Downloads (Pure)

Quantification of the abundance and charging levels of transfer RNAs in Escherichia coli

Stenum, T. S., Sørensen, M. A. & Svenningsen, S. L., 22 Aug 2017, In: Journal of Visualized Experiments. 126, e56212.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Transfer RNA is highly unstable during early amino acid starvation in Escherichia coli

Svenningsen, S. L., Kongstad, M., Stenum, T. S., Muñoz Gomez, A. J. & Sørensen, M. A., 1 Jan 2017, In: Nucleic Acids Research. 45, 2, p. 793-804 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

76 Downloads (Pure)

2016

Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Encoded mRNases

Tian, C., Roghanian, M., Jørgensen, M. G., Sneppen, K., Sørensen, M. A., Gerdes, K. & Mitarai, N., Jul 2016, In: Journal of Bacteriology. 198, 14, p. 1918-1926

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2014

Force spectroscopy of DNA and RNA: structure and kinetics from single-molecule experiments

Ettlinger, R. B., Sørensen, M. A. & Oddershede, L. B., 2014, Nucleic Acid Nanotechnology. Springer, Vol. 29. p. 23-52 31 p. (Nucleic Acids and Molecular Biology, Vol. 29).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2013

A novel complex: a quantum dot conjugated to an active T7 RNA Polymerase

Eriksen, M., Horvath, P., Sørensen, M. A., Semsey, S., Oddershede, L. B. & Pedersen, L. J., 2013, In: Journal of Nanomaterials. 2013, 9 p., 468105.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

1629 Downloads (Pure)

2012

mRNA pseudoknot structures can act as ribosomal roadblocks

Hansen, J. T., Oddershede, L. B. & Sørensen, M. A., Jan 2012, In: Nucleic Acids Research. 40, 1, p. 303-313 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

51 Citations (Scopus)

2007

Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting.

Hansen, T. M., Reihani, S. N. S., Oddershede, L. B. & Sørensen, M. A., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 14, p. 5830-5 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

84 Citations (Scopus)

Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.

Ejby, M., Sørensen, M. A. & Pedersen, S., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 49, p. 19410-5 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

2005

Over Expression of a tRNALeu Isoacceptor Changes Charging Pattern of Leucine tRNAs and Reveals New Codon Reading

Sørensen, M. A., Elf, J., Bouakaz, E., Tenson, T., Sanyal, S., Björk, G. R. & Ehrenberg, M., 2005, In: Journal of Molecular Biology. 354, 1, p. 16-24

Research output: Contribution to journal › Journal article › Research › peer-review

42 Citations (Scopus)

Selective charging of tRNA isoacceptors induced by amino-acid starvation

Dittmar, K. A., Sørensen, M. A., Elf, J., Ehrenberg, M. & Pan, T., 2005, In: EMBO Reports. 6, 2, p. 151–157

Research output: Contribution to journal › Journal article › Research › peer-review

149 Citations (Scopus)

2001

Charging Levels of Four tRNA Species in Escherichia coli Rel⁺ and REL^- Strains during Amino Acid Starvation: A Simple Model for the Effect of ppGpp on Translational Accuracy

Sørensen, M. A., 2001, In: Journal of Molecular Biology. 307, 3, p. 785-798

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

1998

Aminoacylation of hypomodified tRNA^Glu in vivo

Krüger, M. K. & Sørensen, M. A., 1998, In: Journal of Molecular Biology. 284, 3, p. 609-620

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Determination of the Peptide Elongation Rate in vivo

Sørensen, M. A. & Pedersen, S., 1998, Protein Synthesis: Methods and protocols. Totowa, N.J., U.S.A.: Humana Press, p. 129-142

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

7 Citations (Scopus)

Ribosomal Protein S1 required for translation of most, if not all, natural mRNAs in Escherichia coli in vivo

Sørensen, M. A., Fricke, J. & Pedersen, S., 1998, In: Journal of Molecular Biology. 280, p. 561-569

Research output: Contribution to journal › Journal article › Research › peer-review

The modification of the wobble base of tRNA(Glu) modulates the translation rate of glutamic acid codons in vivo

Krüger, M. K., Pedersen, S., Hagervall, T. G. & Sørensen, M. A., 4 Dec 1998, In: Journal of Molecular Biology. 284, 3, p. 621-631 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

101 Citations (Scopus)

The modification of the wobble base of tRNA^Glu modulates the translation rate of glutamic acid codons in vivo

Krüger, M. K., Pedersen, S., Hagervall, T. G. & Sørensen, M. A., 1998, In: J. Mol. Biol.. 284, p. 609-620

Research output: Contribution to journal › Journal article › Research › peer-review

1994

High Concentrations of ppGpp Decrease the RNA Chain Growth Rate. Implications for Protein Synthesis and Translation Fidelity During Amino Acid Starvation in Escherichia coli

Sørensen, M. A., Jensen, K. F. & Pedersen, S., 1994, In: Journal of Molecular Biology. Vol 236, p. 441-454

Research output: Contribution to journal › Journal article › Research › peer-review

1993

Isolation and characterization of mutants with impaired regulation of rpsA, the gene encoding ribosomal protein S1 of Escherichia coli

Rasmussen, M. D., Sørensen, M. A. & Pedersen, S., 1993, In: Molecular Genetics and Genomics. 240, p. 23-28

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Synthesis of proteins in Escherichia coli is limited by the concentration of free ribosomes

Vind, J., Sørensen, M. A., Rasmussen, M. D. & Pedersen, S., 1993, In: Journal of Molecular Biology. Vol. 231, p. 678-688

Research output: Contribution to journal › Journal article › Research › peer-review

145 Citations (Scopus)

1992

Decreasing transcription elongation rate in Escherichia coli exposed to amino acid starvation

Vogel, U., Sørensen, M. A., Pedersen, S., Jensen, K. F. & Kilstrup, M., 1992, In: Molecular Microbiology. 6, 15, p. 2191-2200

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

The rates of macromolecular chain elongation modulate the initiation frequences for transcription and translation in Escherichia coli

Sørensen, M. A., Vogel, U., Jensen, K. F. & Pedersen, S., 1992, In: Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 63, p. 323-331

Research output: Contribution to journal › Journal article › Research

8 Citations (Scopus)

1991

Absolute in vivo translation rates of individual codons in Escherichia coli: The two glutamic acid codons GAA and GAG are translated with a threefold difference in rate

Sørensen, M. A. & Pedersen, S., 1991, In: Journal of Molecular Biology. 222, 2, p. 265-280

Research output: Contribution to journal › Journal article › Research › peer-review

220 Citations (Scopus)

Cysteine, Even in Low Concentrations, Induces Transient Amino Acid Starvation in Escherichia coli

Sørensen, M. A. & Pedersen, S., 1991, In: J. Bacteriol.. Vol.173, no.16, p. 5244-46

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

1990

Measurement of translation rates in vivo at individual codons and implication of these rate differences for gene expression

Sørensen, M. A., Jensen, K. F. & Pedersen, S., 1990, Post-Transcriptional Control of Gene Expression. NATO Asi Series, vol 49. Vol. 49. p. 207-216

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

1989

Codon usage determines translation rate in Escherichia coli

Sørensen, M. A., Kurland, C. G. & Pedersen, S., 1989, In: Journal of Molecular Biology. 207, 2, p. 365-77 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

438 Citations (Scopus)

Michael Askvad Sørensen

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