Michael Askvad Sørensen

Research output

Research output per year 1989 1998 2017 2018

• 24 Journal article
• 2 Book chapter
• 1 Article in proceedings
• 1 Review

Research output per year

Research output per year

Search results

• 2018

  Ribosome Hibernation

  Prossliner, T., Winther, K. S., Sørensen, M. A. & Gerdes, K., 23 Nov 2018, In: Annual Review of Genetics. 52, p. 321-348

  Research output: Contribution to journal › Review › peer-review

  • Hibernation 100%
  • Ribosomes 71%
  • Terminology 17%
  • Proteins 12%
  • Escherichia coli 12%
  38 Citations (Scopus)

• Transfer RNA instability as a stress response in Escherichia coli: rapid dynamics of the tRNA pool as a function of demand

  Sørensen, M. A., Fehler, A. O. & Svenningsen, S. L., 4 May 2018, In: RNA Biology. 15, 4/5, p. 586-593 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA Stability 100%
  • Transfer RNA 99%
  • Escherichia coli 63%
  • DNA-Directed RNA Polymerases 20%
  • Starvation 19%
  12 Citations (Scopus)

  62 Downloads (Pure)
• 2017

  Prophages and growth dynamics confound experimental results with antibiotic-tolerant persister cells

  Harms, A., Fino, C., Sørensen, M. A., Semsey, S. & Gerdes, K., 12 Dec 2017, In: mBio. 8, 6, 18 p., e01964-17.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Prophages 100%
  • Anti-Bacterial Agents 47%
  • Growth 36%
  • Antitoxins 28%
  • Bacteriophages 20%
  104 Citations (Scopus)

  111 Downloads (Pure)

• Quantification of the abundance and charging levels of transfer RNAs in Escherichia coli

  Stenum, T. S., Sørensen, M. A. & Svenningsen, S. L., 22 Aug 2017, In: Journal of Visualized Experiments. 126, e56212.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transfer RNA 100%
  • Transfer RNA Aminoacylation 96%
  • Escherichia coli 76%
  • RNA 22%
  • Northern Blotting 12%
  6 Citations (Scopus)

• Transfer RNA is highly unstable during early amino acid starvation in Escherichia coli

  Svenningsen, S. L., Kongstad, M., Stenum, T. S., Muñoz Gomez, A. J. & Sørensen, M. A., 1 Jan 2017, In: Nucleic Acids Research. 45, 2, p. 793-804 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transfer RNA 100%
  • Starvation 98%
  • Escherichia coli 64%
  • Amino Acids 64%
  • Amino Acid-Specific Transfer RNA 15%
  31 Citations (Scopus)

  76 Downloads (Pure)
• 2016

  Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Encoded mRNases

  Tian, C., Roghanian, M., Jørgensen, M. G., Sneppen, K., Sørensen, M. A., Gerdes, K. & Mitarai, N., Jul 2016, In: Journal of Bacteriology. 198, 14, p. 1918-1926

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Antitoxins 100%
  • Starvation 77%
  • Guanosine Pentaphosphate 34%
  • guanosine 3',5'-polyphosphate synthetases 33%
  • Guanosine Tetraphosphate 31%
  17 Citations (Scopus)
• 2014

  Force spectroscopy of DNA and RNA: structure and kinetics from single-molecule experiments

  Ettlinger, R. B., Sørensen, M. A. & Oddershede, L. B., 2014, Nucleic Acid Nanotechnology. Springer, Vol. 29. p. 23-52 31 p. (Nucleic Acids and Molecular Biology, Vol. 29).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 2013

  A novel complex: a quantum dot conjugated to an active T7 RNA Polymerase

  Eriksen, M., Horvath, P., Sørensen, M. A., Semsey, S., Oddershede, L. B. & Pedersen, L. J., 2013, In: Journal of Nanomaterials. 2013, 9 p., 468105.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA 100%
  • Quantum Dot 73%
  • Biotinylation 39%
  • Molecules 32%
  • Statistical Ensemble 27%
  2 Citations (Scopus)

  1629 Downloads (Pure)
• 2012

  mRNA pseudoknot structures can act as ribosomal roadblocks

  Hansen, J. T., Oddershede, L. B. & Sørensen, M. A., Jan 2012, In: Nucleic Acids Research. 40, 1, p. 303-313 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ribosomes 100%
  • Messenger RNA 82%
  • Ribosomal Frameshifting 76%
  • Terminator Codon 57%
  • Electrophoresis, Gel, Two-Dimensional 56%
  51 Citations (Scopus)
• 2007

  Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting.

  Hansen, T. M., Reihani, S. N. S., Oddershede, L. B. & Sørensen, M. A., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 14, p. 5830-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ribosomal Frameshifting 100%
  • Reading Frames 82%
  • Ribosomes 65%
  • Messenger RNA 35%
  • Transfer RNA 34%
  84 Citations (Scopus)

• Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination.

  Ejby, M., Sørensen, M. A. & Pedersen, S., 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 49, p. 19410-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 23S Ribosomal RNA 100%
  • Codon 71%
  • Pseudouridine 69%
  • Terminator Codon 51%
  • Reading 25%
  48 Citations (Scopus)
• 2005

  Over Expression of a tRNALeu Isoacceptor Changes Charging Pattern of Leucine tRNAs and Reveals New Codon Reading

  Sørensen, M. A., Elf, J., Bouakaz, E., Tenson, T., Sanyal, S., Björk, G. R. & Ehrenberg, M., 2005, In: Journal of Molecular Biology. 354, 1, p. 16-24

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA, Transfer, Leu 100%
  • Transfer RNA 70%
  • Transfer RNA Aminoacylation 68%
  • Leucine 65%
  • Codon 63%
  42 Citations (Scopus)

• Selective charging of tRNA isoacceptors induced by amino-acid starvation

  Dittmar, K. A., Sørensen, M. A., Elf, J., Ehrenberg, M. & Pan, T., 2005, In: EMBO Reports. 6, 2, p. 151–157

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transfer RNA Aminoacylation 100%
  • Threonine 69%
  • Starvation 67%
  • Leucine 64%
  • Arginine 62%
  149 Citations (Scopus)
• 2001

  Charging Levels of Four tRNA Species in Escherichia coli Rel⁺ and REL^- Strains during Amino Acid Starvation: A Simple Model for the Effect of ppGpp on Translational Accuracy

  Sørensen, M. A., 2001, In: Journal of Molecular Biology. 307, 3, p. 785-798

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transfer RNA 100%
  • Starvation 98%
  • Escherichia coli 64%
  • Amino Acids 64%
  • RNA, Transfer, His 27%
  62 Citations (Scopus)
• 1998

  Aminoacylation of hypomodified tRNA^Glu in vivo

  Krüger, M. K. & Sørensen, M. A., 1998, In: Journal of Molecular Biology. 284, 3, p. 609-620

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA, Transfer, Glu 100%
  • Aminoacylation 82%
  • Transfer RNA 62%
  • Amino Acyl-tRNA Synthetases 58%
  • Glutamate-tRNA Ligase 52%
  54 Citations (Scopus)

• Determination of the Peptide Elongation Rate in vivo

  Sørensen, M. A. & Pedersen, S., 1998, Protein Synthesis: Methods and protocols. Totowa, N.J., U.S.A.: Humana Press, p. 129-142

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  7 Citations (Scopus)

• Ribosomal Protein S1 required for translation of most, if not all, natural mRNAs in Escherichia coli in vivo

  Sørensen, M. A., Fricke, J. & Pedersen, S., 1998, In: Journal of Molecular Biology. 280, p. 561-569

  Research output: Contribution to journal › Journal article › Research › peer-review

• The modification of the wobble base of tRNA(Glu) modulates the translation rate of glutamic acid codons in vivo

  Krüger, M. K., Pedersen, S., Hagervall, T. G. & Sørensen, M. A., 4 Dec 1998, In: Journal of Molecular Biology. 284, 3, p. 621-631 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA, Transfer, Glu 100%
  • Codon 55%
  • Glutamic Acid 49%
  • Base Pairing 13%
  • RNA, Transfer, Lys 7%
  101 Citations (Scopus)

• The modification of the wobble base of tRNA^Glu modulates the translation rate of glutamic acid codons in vivo

  Krüger, M. K., Pedersen, S., Hagervall, T. G. & Sørensen, M. A., 1998, In: J. Mol. Biol.. 284, p. 609-620

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1994

  High Concentrations of ppGpp Decrease the RNA Chain Growth Rate. Implications for Protein Synthesis and Translation Fidelity During Amino Acid Starvation in Escherichia coli

  Sørensen, M. A., Jensen, K. F. & Pedersen, S., 1994, In: Journal of Molecular Biology. Vol 236, p. 441-454

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1993

  Isolation and characterization of mutants with impaired regulation of rpsA, the gene encoding ribosomal protein S1 of Escherichia coli

  Rasmussen, M. D., Sørensen, M. A. & Pedersen, S., 1993, In: Molecular Genetics and Genomics. 240, p. 23-28

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)

• Synthesis of proteins in Escherichia coli is limited by the concentration of free ribosomes

  Vind, J., Sørensen, M. A., Rasmussen, M. D. & Pedersen, S., 1993, In: Journal of Molecular Biology. Vol. 231, p. 678-688

  Research output: Contribution to journal › Journal article › Research › peer-review

  145 Citations (Scopus)
• 1992

  Decreasing transcription elongation rate in Escherichia coli exposed to amino acid starvation

  Vogel, U., Sørensen, M. A., Pedersen, S., Jensen, K. F. & Kilstrup, M., 1992, In: Molecular Microbiology. 6, 15, p. 2191-2200

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Starvation 100%
  • Escherichia coli 64%
  • Amino Acids 64%
  • Messenger RNA 52%
  • Isoleucine 49%
  52 Citations (Scopus)

• The rates of macromolecular chain elongation modulate the initiation frequences for transcription and translation in Escherichia coli

  Sørensen, M. A., Vogel, U., Jensen, K. F. & Pedersen, S., 1992, In: Antonie van Leeuwenhoek. International Journal of General and Molecular Microbiology. 63, p. 323-331

  Research output: Contribution to journal › Journal article › Research

  8 Citations (Scopus)
• 1991

  Absolute in vivo translation rates of individual codons in Escherichia coli: The two glutamic acid codons GAA and GAG are translated with a threefold difference in rate

  Sørensen, M. A. & Pedersen, S., 1991, In: Journal of Molecular Biology. 222, 2, p. 265-280

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Codon 100%
  • Glutamic Acid 88%
  • Escherichia coli 71%
  • Transfer RNA 22%
  • Ribosomes 21%
  220 Citations (Scopus)

• Cysteine, Even in Low Concentrations, Induces Transient Amino Acid Starvation in Escherichia coli

  Sørensen, M. A. & Pedersen, S., 1991, In: J. Bacteriol.. Vol.173, no.16, p. 5244-46

  Research output: Contribution to journal › Journal article › Research › peer-review

  38 Citations (Scopus)
• 1990

  Measurement of translation rates in vivo at individual codons and implication of these rate differences for gene expression

  Sørensen, M. A., Jensen, K. F. & Pedersen, S., 1990, Post-Transcriptional Control of Gene Expression. NATO Asi Series, vol 49. Vol. 49. p. 207-216

  Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
• 1989

  Codon usage determines translation rate in Escherichia coli

  Sørensen, M. A., Kurland, C. G. & Pedersen, S., 1989, In: Journal of Molecular Biology. 207, 2, p. 365-77 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Codon Usage 100%
  • Codon 62%
  • Escherichia coli 51%
  • Messenger RNA 41%
  • Reading Frames 35%
  438 Citations (Scopus)