Lars Ellgaard

2019

Cellular functions and molecular mechanisms of non-lysine ubiquitination

McClellan, A. J., Laugesen, S. H. & Ellgaard, L., 2019, In: Open Biology. 9, 9, 16 p., 190147.

Research output: Contribution to journal › Review › peer-review

24 Citations (Scopus)

12 Downloads (Pure)

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi-Hemami, H., Teilum, K. & Ellgaard, L., 31 May 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2018

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

O'Brien, H., Kanemura, S., Okumura, M., Baskin, R. P., Bandyopadhyay, P. K., Olivera, B. M., Ellgaard, L., Inaba, K. & Safavi-Hemami, H., Nov 2018, In: International Journal of Molecular Sciences . 19, 11, p. 1-15 3418.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

45 Downloads (Pure)

Evolutionary Adaptations to Cysteine-rich Peptide Folding

Safavi-Hemami, H., Foged, M. M. & Ellgaard, L., 2018, Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering . Feige, M. J. (ed.). Royal Society of Chemistry, p. 99-128 30 p. (Chemical Biology, Vol. 9).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

How are proteins reduced in the endoplasmic reticulum?

Ellgaard, L., Sevier, C. S. & Bulleid, N. J., Jan 2018, In: Trends in Biochemical Sciences. 43, 1, p. 32-43 12 p.

Research output: Contribution to journal › Review › peer-review

43 Citations (Scopus)

21 Downloads (Pure)

2016

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

Boomsma, W. K., Nielsen, S. V., Lindorff-Larsen, K., Hartmann-Petersen, R. & Ellgaard, L., 2016, In: PeerJ. 4, 18 p., e1725.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

103 Downloads (Pure)

Co- and post-translational protein folding in the ER

Ellgaard, L., McCaul, N., Chatsisvili, A. & Braakman, I., 1 Jun 2016, In: Traffic (Malden). 17 , 6, p. 615-638 24 p.

Research output: Contribution to journal › Review › peer-review

55 Citations (Scopus)

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

Timms, R. T., Menzies, S. A., Tchasovnikarova, I. A., Christensen, L. C., Williamson, J. C., Antrobus, R., Dougan, G., Ellgaard, L. & Lehner, P. J., 10 Jun 2016, In: Nature Communications. 7, 10 p., 11786.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

390 Downloads (Pure)

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

Safavi-Hemami, H., Li, Q., Jackson, R. L., Song, A. S., Boomsma, W. K., Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, L., 22 Mar 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3227-3232 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2015

Specialized insulin is used for chemical warfare by fish-hunting cone snails

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S. D., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, L. & Olivera, B. M., 10 Feb 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743-1748 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

2014

Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

Hansen, H. G., Søltoft, C. L., Schmidt, J. D., Birk, J., Appenzeller-Herzog, C. & Ellgaard, L., 2014, In: Bioscience Reports. 34, 2, 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

767 Downloads (Pure)

Giftsnegle som medicinskabe

Safavi-Hemami, H., Andersen, K. M. & Ellgaard, L., 2014, In: Aktuel Naturvidenskab. 2, p. 12-16 5 p.

Research output: Contribution to journal › Journal article › Research

GPx8 peroxidase prevents leakage of H₂O₂ from the endoplasmic reticulum

Ramming, T., Hansen, H. G., Nagata, K., Ellgaard, L. & Appenzeller-Herzog, C., May 2014, In: Free Radical Biology & Medicine. 70, p. 106-116 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

75 Citations (Scopus)

The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D

Hagemann-Jensen, M. H., Uhlenbrock, F. K., Kehlet, S., Andresen, L., Gabel-Jensen, C., Ellgaard, L., Gammelgaard, B. & Skov, S., 7 Nov 2014, In: The Journal of Biological Chemistry. 289, p. 31576-31590 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

2012

HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin

Poulsen, E. G., Steinhauer, C., Lees, M., Lauridsen, A-M., Ellgaard, L. & Hartmann-Petersen, R., 27 Nov 2012, In: P L o S One. 7, 11, 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

1752 Downloads (Pure)

Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response

Hansen, H. G., Schmidt, J. D., Søltoft, C. L., Ramming, T., Geertz-Hansen, H. M., Christensen, B., Sørensen, E. S., Juncker, A., Appenzeller, C. A. & Ellgaard, L., 16 Nov 2012, In: Journal of Biological Chemistry. 287, 47, p. 39513-39523 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

Kriegenburg, F., Ellgaard, L. & Hartmann-Petersen, R., Feb 2012, In: F E B S Journal. 279, 4, p. 532-542 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

82 Citations (Scopus)

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

Lynes, E. M., Bui, M., Yap, M. C., Benson, M. D., Schneider, B., Ellgaard, L., Berthiaume, L. G. & Simmen, T., 18 Jan 2012, In: E M B O Journal. 31, 2, p. 457-470 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

128 Citations (Scopus)

The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, J. R., Hofmann, K., Teilum, K. & Ellgaard, L., 27 Jul 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

2011

Identification of the PDI-family member ERp90 as an interaction partner of ERFAD

Riemer, J., Hansen, H. G., Appenzeller-Herzog, C., Appenzeller-Herzog, C., Johansson, L. & Ellgaard, L., 2011, In: P L o S One. 6, 2, 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

873 Downloads (Pure)

Multiple ways to make disulfides

Bulleid, N. J. & Ellgaard, L., Sept 2011, In: Trends in Biochemical Sciences. 36, 9, p. 485-92 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

160 Citations (Scopus)

2010

A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

Roth, D., Lynes, E., Riemer, J., Hansen, H. G., Althaus, N., Simmen, T. & Ellgaard, L., 1 Jan 2010, In: Biochemical Journal. 425, 1, p. 195-205 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

A male with unilateral microphthalmia reveals a role for TMX3 in eye development

Chao, R., Nevin, L., Agarwal, P., Riemer, J., Bai, X., Delaney, A., Akana, M., JimenezLopez, N., Bardakjian, T., Schneider, A., Chassaing, N., Schorderet, D. F., FitzPatrick, D., Kwok, P., Ellgaard, L., Gould, D. B., Zhang, Y., Malicki, J., Baier, H. & Slavotinek, A., 2010, In: PLoS ONE. 5, 5, p. e10565 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

427 Downloads (Pure)

Disulphide production by Ero1a-PDI relay is rapid and effectively regulated

Appenzeller-Herzog, C., Riemer, J., Zito, E., Chin, K-T., Ron, D., Spiess, M. & Ellgaard, L., 6 Oct 2010, In: EMBO Journal. 29, 19, p. 3318-29 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

100 Citations (Scopus)

2009

A luminal flavoprotein in endoplasmic reticulum-associated degradation

Riemer, J., Appenzeller-Herzog, C., Johansson, L., Bodenmiller, B., Hartmann-Petersen, R. & Ellgaard, L., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 35, p. 14831-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

2008

A novel disulphide switch mechanism in Ero1 balances ER oxidation in human cells

Appenzeller-Herzog, C., Riemer, J., Christensen, B., Sørensen, E. B. & Ellgaard, L., 2008, In: EMBO Journal. 27, p. 2977–2987

Research output: Contribution to journal › Journal article › Research › peer-review

134 Citations (Scopus)

In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms

Appenzeller-Herzog, C. & Ellgaard, L., 2008, In: Antioxidants & Redox Signaling. 10, 1, p. 55-64 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

78 Citations (Scopus)

2007

Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells.

Schelhaas, M., Malmström, J., Pelkmans, L., Haugstetter, J., Ellgaard, L., Grünewald, K. & Helenius, A., 2007, In: Cell. 131, 3, p. 516-29 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

240 Citations (Scopus)

Structure-function analysis of the ER oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain

Haugstetter, J., Michael, M., Blicher, T., Pagac, M., Wider, G. & Ellgaard, L., 2007, In: Journal of Biological Chemistry. 280, 46, p. 33859-33867

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

The human PDI family: Versatility packed into a single fold.

Appenzeller-Herzog, C. & Ellgaard, L., 2007, In: BBA General Subjects.

Research output: Contribution to journal › Review › peer-review

290 Citations (Scopus)

2006

Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.

Kulp, M. S., Frickel, E. M., Ellgaard, L. & Weismann, J. S., 2006, In: Journal of Biological Chemistry. 281, 2, p. 876-84.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Lars Ellgaard

Research output

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