Kyoung Jae Won

Research output

Research output per year 2004 2013 2014 2015 2016 2017 2018 2019

• 60 Journal article
• 1 Article in proceedings
• 1 Review

Research output per year

Research output per year

Search results

• 2019

  Genomic architecture of Shh-dependent cochlear morphogenesis

  Muthu, V., Rohacek, A. M., Yao, Y., Rakowiecki, S. M., Brown, A. S., Zhao, Y-T., Meyers, J., Won, K-J., Ramdas, S., Brown, C. D., Peterson, K. A. & Epstein, D. J., 19 Sept 2019, In: Development (Cambridge, England). 146, 18, 12 p., 181339.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cochlea 100%
  • Cochlear Duct 99%
  • Morphogenesis 95%
  • Ear 83%
  • Chromatin Immunoprecipitation Sequencing 82%
  4 Citations (Scopus)
• 2018

  CellBIC: bimodality-based top-down clustering of single-cell RNA sequencing data reveals hierarchical structure of the cell type

  Kim, J., Stanescu, D. E. & Won, K. J., 30 Nov 2018, In: Nucleic Acids Research. 46, 21, p. 1-8 8 p., e124.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • RNA Sequence Analysis 100%
  • Cluster Analysis 79%
  • Type 2 Diabetes Mellitus 6%
  • Gene Expression 4%
  • Population 3%
  3 Citations (Scopus)

  48 Downloads (Pure)

• Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus

  Condon, D. E., Tran, P. V., Lien, Y-C., Schug, J., Georgieff, M. K., Simmons, R. A. & Won, K-J., 5 Feb 2018, In: BMC Bioinformatics. 19, 1, p. 31

  Research output: Contribution to journal › Journal article › Research › peer-review

  • DNA Methylation 100%
  • Hippocampus 95%
  • Annotation 83%
  • Iron 78%
  • hydrogen sulfite 76%
  12 Citations (Scopus)

• Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

  Hill, D. A., Lim, H-W., Kim, Y. H., Ho, W. Y., Foong, Y. H., Nelson, V. L., Nguyen, H. C. B., Chegireddy, K., Kim, J., Habertheuer, A., Vallabhajosyula, P., Kambayashi, T., Won, K-J. & Lazar, M. A., 29 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. E5096-E5105

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adipose Tissue 100%
  • Macrophages 83%
  • Crowns 78%
  • Adoptive Transfer 55%
  • Obesity 50%
  83 Citations (Scopus)

• PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

  Kim, D., Nam, H. J., Lee, W., Yim, H. Y., Ahn, J-Y., Park, S. W., Shin, H-J. R., Yu, R., Won, K-J., Bae, J-S., Kim, K. I. & Baek, S. H., 1 Feb 2018, In: Molecular Cell. 69, 3, p. 398-411.e6

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Epigenomics 100%
  • Phosphorylation 78%
  • Sepsis 61%
  • Demethylation 45%
  • Lung Injury 40%
  26 Citations (Scopus)

• Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription

  Kim, Y. H., Marhon, S. A., Zhang, Y., Steger, D. J., Won, K-J. & Lazar, M. A., 16 Mar 2018, In: Science (New York, N.Y.). 359, 6381, p. 1274-1277 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin 100%
  • Transcription Factors 85%
  • Gene Expression 67%
  • Peptide Elongation Factors 52%
  • Co-Repressor Proteins 48%
  76 Citations (Scopus)

• Shared nucleotide flanks confer transcriptional competency to bZip core motifs

  Cohen, D. M., Lim, H-W., Won, K-J. & Steger, D. J., 19 Sept 2018, In: Nucleic Acids Research. 46, 16, p. 8371-8384

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nucleotides 100%
  • Transcription Factors 93%
  • Binding Sites 38%
  • Genome 33%
  • DNA 27%
  3 Citations (Scopus)

  55 Downloads (Pure)

• Transcriptomic Analysis Reveals Novel Mechanisms Mediating Islet Dysfunction in the Intrauterine Growth-Restricted Rat

  Rashid, C. S., Lien, Y-C., Bansal, A., Jaeckle-Santos, L. J., Li, C., Won, K-J. & Simmons, R. A., 1 Feb 2018, In: Endocrinology. 159, 2, p. 1035-1049 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Intrauterine 100%
  • Fetal Growth Retardation 68%
  • Growth 31%
  • RNA Sequencing 12%
  • Hyaluronan Synthases 12%
  6 Citations (Scopus)
• 2017

  DNA hypermethylation induced by Epstein-Barr virus in the development of Epstein-Barr virus-associated gastric carcinoma

  Choi, S. J., Shin, Y. S., Kang, B. W., Kim, J. G., Won, K-J., Lieberman, P. M., Cho, H. & Kang, H., 1 Aug 2017, In: Archives of Pharmacal Research. 40, 8, p. 894-905 12 p.

  Research output: Contribution to journal › Review › peer-review

  • Human Herpesvirus 4 100%
  • Stomach 72%
  • Carcinoma 66%
  • DNA 56%
  • Epigenomics 26%
  11 Citations (Scopus)

• EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex

  Shapira, S. N., Lim, H-W., Rajakumari, S., Sakers, A. P., Ishibashi, J., Harms, M. J., Won, K-J. & Seale, P., 1 Apr 2017, In: Genes & Development. 31, 7, p. 660-673 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adipogenesis 100%
  • Chromatin Assembly and Disassembly 97%
  • Histones 77%
  • Brown Adipose Tissue 76%
  • B-Lymphocytes 64%
  30 Citations (Scopus)

• LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells

  Ediger, B. N., Lim, H-W., Juliana, C., Groff, D. N., Williams, L. T., Dominguez, G., Liu, J-H., Taylor, B. L., Walp, E. R., Kameswaran, V., Yang, J., Liu, C., Hunter, C. S., Kaestner, K. H., Naji, A., Li, C., Sander, M., Stein, R., Sussel, L., Won, K-J., & 2 othersMay, C. L. & Stoffers, D. A., 3 Jan 2017, In: The Journal of Clinical Investigation. 127, 1, p. 215-229 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • LIM Domain Proteins 100%
  • Carrier Proteins 52%
  • Homeobox Genes 27%
  • Mouse Ldb1 protein 18%
  • Endocrine Cells 18%
  39 Citations (Scopus)

• PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing

  Kissig, M., Ishibashi, J., Harms, M. J., Lim, H-W., Stine, R. R., Won, K-J. & Seale, P., 1 Jun 2017, In: E M B O Journal. 36, 11, p. 1528-1542 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Thermogenic 100%
  • Interferon Type I 68%
  • Brown 59%
  • Adipocytes 54%
  • Genes 23%
  25 Citations (Scopus)

• Single cell transcriptomic profiling of mouse pancreatic progenitors

  Stanescu, D. E., Yu, R., Won, K-J. & Stoffers, D. A., 14 Feb 2017, In: Physiological Genomics. 49, 2, p. 105-114 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pancreas 100%
  • Neutral Amino Acid Transport Systems 96%
  • Proglucagon 92%
  • Single-Cell Analysis 78%
  • Endocrine Cells 70%
  17 Citations (Scopus)

• Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice

  Soccio, R. E., Li, Z., Chen, E. R., Foong, Y. H., Benson, K. K., Dispirito, J. R., Mullican, S. E., Emmett, M. J., Briggs, E. R., Peed, L. C., Dzeng, R. K., Medina, C. J., Jolivert, J. F., Kissig, M., Rajapurkar, S. R., Damle, M., Lim, H-W., Won, K-J., Seale, P., Steger, D. J., & 1 othersLazar, M. A., 3 Apr 2017, In: The Journal of Clinical Investigation. 127, 4, p. 1451-1462 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Epigenome 100%
  • Peroxisome Proliferator-Activated Receptors 96%
  • Rosiglitazone 85%
  • Obesity 37%
  • High Fat Diet 26%
  26 Citations (Scopus)
• 2016

  AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy

  Shin, H-J. R., Kim, H., Oh, S., Lee, J-G., Kee, M., Ko, H-J., Kweon, M-N., Won, K-J. & Baek, S. H., 15 Jun 2016, In: Nature. 534, 7608, p. 553-7 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • human PRMT2 protein 100%
  • AMP-Activated Protein Kinases 69%
  • Autophagy 56%
  • Nutrients 28%
  • Starvation 27%
  191 Citations (Scopus)

• EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

  Stine, R. R., Shapira, S. N., Lim, H-W., Ishibashi, J., Harms, M., Won, K-J. & Seale, P., 1 Jan 2016, In: Molecular Metabolism. 5, 1, p. 57-65 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Beige Adipocytes 100%
  • White Adipose Tissue 75%
  • B-Lymphocytes 47%
  • Uncoupling Protein 1 19%
  • Primary Cell Culture 16%
  41 Citations (Scopus)

• EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1

  Lu, F., Chen, H-S., Kossenkov, A. V., DeWispeleare, K., Won, K-J. & Lieberman, P. M., Jan 2016, In: PLOS Pathogens. 12, 1, p. e1005339

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Regulatory B-Lymphocytes 100%
  • B-lymphocytes 65%
  • Human gammaherpesvirus 4 59%
  • binding sites 56%
  • Chromosomes 52%
  25 Citations (Scopus)

• Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation

  Kim, R., Sheaffer, K. L., Choi, I., Won, K-J. & Kaestner, K. H., 1 Nov 2016, In: Genes & Development. 30, 21, p. 2433-2442 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 5-hydroxymethylcytosine 100%
  • Cytosine 78%
  • Epigenomics 57%
  • Mixed Function Oxygenases 49%
  • Stem Cells 48%
  31 Citations (Scopus)

• Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells

  Gonzales-Cope, M., Sidoli, S., Bhanu, N. V., Won, K-J. & Garcia, B. A., 4 Feb 2016, In: BMC Genomics. 17, p. 95

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Embryonic Stem Cells 100%
  • Acetylation 98%
  • Histones 88%
  • Epigenomics 81%
  • Post Translational Protein Processing 55%
  30 Citations (Scopus)

• Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus

  Tran, P. V., Kennedy, B. C., Pisansky, M. T., Won, K-J., Gewirtz, J. C., Simmons, R. A. & Georgieff, M. K., Mar 2016, In: The Journal of Nutrition. 146, 3, p. 484-93 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Choline 100%
  • Iron 77%
  • Hippocampus 74%
  • Autistic Disorder 20%
  • Transcriptome 18%
  23 Citations (Scopus)

• Single-Cell Transcriptomics of the Human Endocrine Pancreas

  Wang, Y. J., Schug, J., Won, K-J., Liu, C., Naji, A., Avrahami, D., Golson, M. L. & Kaestner, K. H., 1 Oct 2016, In: Diabetes. 65, 10, p. 3028-38 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Islets of Langerhans 100%
  • Endocrine Cells 34%
  • RNA Sequence Analysis 31%
  • Tissue Donors 22%
  • Type 2 Diabetes Mellitus 21%
  157 Citations (Scopus)

• Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

  Shah, S., Carriveau, W. J., Li, J., Campbell, S. L., Kopinski, P. K., Lim, H-W., Daurio, N., Trefely, S., Won, K-J., Wallace, D. C., Koumenis, C., Mancuso, A. & Wellen, K. E., 12 Jul 2016, In: OncoTarget. 7, 28, p. 43713-43730 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ATP Citrate (pro-S)-Lyase 100%
  • Castration 69%
  • Androgen Receptors 67%
  • Prostatic Neoplasms 49%
  • Fatty Acids 26%
  36 Citations (Scopus)

• The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling

  Jager, J., Wang, F., Fang, B., Lim, H-W., Peed, L. C., Steger, D. J., Won, K-J., Kharitonenkov, A., Adams, A. C. & Lazar, M. A., 13 May 2016, In: The Journal of Biological Chemistry. 291, 20, p. 10867-75 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • fibroblast growth factor 21 100%
  • Cytoplasmic and Nuclear Receptors 70%
  • White 57%
  • Adipose Tissue 57%
  • Enhancer 40%
  18 Citations (Scopus)

• Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function

  Henley, K. D., Stanescu, D. E., Kropp, P. A., Wright, C. V. E., Won, K-J., Stoffers, D. A. & Gannon, M., 21 Jun 2016, In: Cell Reports. 15, 12, p. 2637-2650 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endocrine Cells 100%
  • Hormone 82%
  • Wave 76%
  • Pancreas 28%
  • Organogenesis 20%
  5 Citations (Scopus)
• 2015

  A stationary wavelet entropy-based clustering approach accurately predicts gene expression

  Nguyen, N., Vo, A., Choi, I. & Won, K-J., 1 Mar 2015, In: Journal of computational biology : a journal of computational molecular cell biology. 22, 3, p. 236-49 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gene Expression 100%
  • Entropy 95%
  • Gene expression 87%
  • Genes 75%
  • Clustering 75%
  7 Citations (Scopus)

• ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

  Cohen, D. M., Won, K-J., Nguyen, N., Lazar, M. A., Chen, C. S. & Steger, D. J., 25 Jun 2015, In: eLife. 4, p. e06821

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adipogenesis 100%
  • Heterodimer 94%
  • Licensure 90%
  • Human Activities 83%
  • Mesenchymal Stem Cells 74%
  25 Citations (Scopus)

• Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo

  Soccio, R. E., Chen, E. R., Rajapurkar, S. R., Safabakhsh, P., Marinis, J. M., Dispirito, J. R., Emmett, M. J., Briggs, E. R., Fang, B., Everett, L. J., Lim, H-W., Won, K-J., Steger, D. J., Wu, Y., Civelek, M., Voight, B. F. & Lazar, M. A., 3 Jul 2015, In: Cell. 162, 1, p. 33-44 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Antidiabetic Agent 100%
  • Peroxisome Proliferator-Activated Receptors 98%
  • Genetic Variation 79%
  • Single Nucleotide Polymorphism 57%
  • Drug 43%
  77 Citations (Scopus)

• Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

  Lim, H-W., Uhlenhaut, N. H., Rauch, A., Weiner, J., Hübner, S., Hübner, N., Won, K-J., Lazar, M. A., Tuckermann, J. & Steger, D. J., 1 Jun 2015, In: Genome Research. 25, 6, p. 836-44 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucocorticoid Receptors 100%
  • Glucocorticoids 82%
  • Chromatin Immunoprecipitation Sequencing 19%
  • Corticosterone 15%
  • Liver 15%
  105 Citations (Scopus)

• Integrative analysis of 111 reference human epigenomes

  Won, K. J. & Roadmap Epigenomics Consortium, 19 Feb 2015, In: Nature. 518, 7539, p. 317-30 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Epigenome 100%
  • Epigenomics 46%
  • Histone Code 15%
  • Human Genome 14%
  • DNA Methylation 13%
  2760 Citations (Scopus)

• Nonparametric Tests for Differential Histone Enrichment with ChIP-Seq Data

  Wu, Q., Won, K-J. & Li, H., 27 Jan 2015, In: Cancer Informatics. 14, Suppl 1, p. 11-22 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chromatin Immunoprecipitation Sequencing 100%
  • Histones 72%
  • Histone Code 39%
  • Genes 13%
  • Binomial Distribution 13%
  1 Citation (Scopus)

• PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

  Harms, M. J., Lim, H-W., Ho, Y., Shapira, S. N., Ishibashi, J., Rajakumari, S., Steger, D. J., Lazar, M. A., Won, K-J. & Seale, P., 1 Feb 2015, In: Genes & Development. 29, 3, p. 298-307 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brown Adipose Tissue 100%
  • Chromatin 72%
  • Chromatin Immunoprecipitation 22%
  • Genes 16%
  • Mediator Complex 15%
  76 Citations (Scopus)

• Proteogenomics analysis reveals specific genomic orientations of distal regulatory regions composed by non-canonical histone variants

  Won, K-J., Choi, I., LeRoy, G., Zee, B. M., Sidoli, S., Gonzales-Cope, M. & Garcia, B. A., 10 Apr 2015, In: Epigenetics & Chromatin. 8, p. 13

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteogenomics 100%
  • Nucleic Acid Regulatory Sequences 69%
  • Histones 56%
  • Chromatin Immunoprecipitation 26%
  • DNA Packaging 8%
  8 Citations (Scopus)

• The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress

  Lake, R. J., Boetefuer, E. L., Won, K-J. & Fan, H-Y., 17 Nov 2015, In: Nucleic Acids Research. 44, 5, p. 2125-35 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CCCTC-Binding Factor 100%
  • Cockayne Syndrome 57%
  • Chromatin 55%
  • Oxidative Stress 45%
  • Premature Aging 16%
  24 Citations (Scopus)

• Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation

  Kang, S. C., Kim, S. K., Chai, J. C., Kim, S. H., Won, K-J., Lee, Y. S., Jung, K. H. & Chai, Y. G., 11 Aug 2015, In: PLoS ONE. 10, 8, p. e0135276

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Differentiation 100%
  • Profiling 89%
  • Developmental Genes 86%
  • Transcription 85%
  • cell differentiation 63%
  10 Citations (Scopus)
• 2014

  5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation

  Choi, I., Kim, R., Lim, H-W., Kaestner, K. H. & Won, K-J., 14 Aug 2014, In: BMC Genomics. 15, p. 670

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 5-hydroxymethylcytosine 100%
  • Embryonic Stem Cells 70%
  • Epigenomics 57%
  • Mouse Embryonic Stem Cells 34%
  • Genes 26%
  19 Citations (Scopus)

• Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

  Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z-F., Lim, H-W., Liu, S., Jackson, E., Aiello, N. M., Haas, N. B., Rebbeck, T. R., Judkins, A., Won, K-J., Chodosh, L. A., Garcia, B. A., Stanger, B. Z., Feldman, M. D., & 2 othersBlair, I. A. & Wellen, K. E., 5 Aug 2014, In: Cell Metabolism. 20, 2, p. 306-319 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Histones 89%
  • Acetyl Coenzyme A 71%
  • Neoplasms 30%
  • ATP Citrate (pro-S)-Lyase 21%
  270 Citations (Scopus)

• Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers

  Step, S. E., Lim, H-W., Marinis, J. M., Prokesch, A., Steger, D. J., You, S-H., Won, K-J. & Lazar, M. A., 1 May 2014, In: Genes & Development. 28, 9, p. 1018-28 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Rosiglitazone 100%
  • Peroxisome Proliferator-Activated Receptors 94%
  • Adipocytes 74%
  • Transcriptome 72%
  • Ligands 33%
  66 Citations (Scopus)

• A wavelet approach to detect enriched regions and explore epigenomic landscapes

  Nguyen, N., Vo, A. & Won, K-J., 1 Nov 2014, In: Journal of computational biology : a journal of computational molecular cell biology. 21, 11, p. 846-54 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Transcription factors 100%
  • Histone Code 79%
  • Gene expression 76%
  • Genomics 72%
  • Genes 66%
  4 Citations (Scopus)

• A wavelet-based method to exploit epigenomic language in the regulatory region

  Nguyen, N., Vo, A. & Won, K-J., 1 Apr 2014, In: Bioinformatics (Online). 30, 7, p. 908-14 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nucleic Acid Regulatory Sequences 100%
  • Gene expression 94%
  • Histone 93%
  • Wavelets 76%
  • Epigenomics 75%
  5 Citations (Scopus)

• Ebf2 is a selective marker of brown and beige adipogenic precursor cells

  Wang, W., Kissig, M., Rajakumari, S., Huang, L., Lim, H-W., Won, K-J. & Seale, P., 7 Oct 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14466-71 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • B-Lymphocytes 100%
  • Brown Adipocytes 46%
  • Myoblasts 37%
  • Myogenic Regulatory Factor 5 30%
  • Embryonic Structures 26%
  111 Citations (Scopus)

• Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets

  Kameswaran, V., Bramswig, N. C., McKenna, L. B., Penn, M., Schug, J., Hand, N. J., Chen, Y., Choi, I., Vourekas, A., Won, K-J., Liu, C., Vivek, K., Naji, A., Friedman, J. R. & Kaestner, K. H., 7 Jan 2014, In: Cell Metabolism. 19, 1, p. 135-45 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Epigenomics 100%
  • MicroRNAs 96%
  • Type 2 Diabetes Mellitus 86%
  • Tissue Donors 44%
  • Down-Regulation 40%
  190 Citations (Scopus)

• Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice

  Harms, M. J., Ishibashi, J., Wang, W., Lim, H-W., Goyama, S., Sato, T., Kurokawa, M., Won, K-J. & Seale, P., 1 Apr 2014, In: Cell Metabolism. 19, 4, p. 593-604 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brown Adipocytes 100%
  • Brown Adipose Tissue 85%
  • Maintenance 49%
  • Beige Adipocytes 16%
  • Histone Methyltransferases 13%
  191 Citations (Scopus)

• RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking

  Lake, R. J., Tsai, P-F., Choi, I., Won, K-J. & Fan, H-Y., Mar 2014, In: PLOS Genetics. 10, 3, p. e1004204

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mitosis 100%
  • mitosis 97%
  • chromatin 90%
  • Chromatin 89%
  • cell 62%
  44 Citations (Scopus)

• The sequence-specific transcription factor c-Jun targets Cockayne syndrome protein B to regulate transcription and chromatin structure

  Lake, R. J., Boetefuer, E. L., Tsai, P-F., Jeong, J., Choi, I., Won, K-J. & Fan, H-Y., Apr 2014, In: PLOS Genetics. 10, 4, p. e1004284

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cockayne Syndrome 100%
  • IgA receptor 86%
  • genomics 65%
  • chromatin 58%
  • Chromatin 58%
  22 Citations (Scopus)
• 2013

  An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression

  Kim, J., Hoffman, J. P., Alpaugh, R. K., Rhim, A. D., Rhimm, A. D., Reichert, M., Stanger, B. Z., Furth, E. E., Sepulveda, A. R., Yuan, C-X., Won, K-J., Donahue, G., Sands, J., Gumbs, A. A. & Zaret, K. S., 27 Mar 2013, In: Cell Reports. 3, 6, p. 2088-99 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Induced Pluripotent Stem Cells 100%
  • Pancreatic Neoplasms 83%
  • Adenocarcinoma 69%
  • Cell Line 52%
  • Protein 36%
  96 Citations (Scopus)

• Comparative annotation of functional regions in the human genome using epigenomic data

  Won, K-J., Zhang, X., Wang, T., Ding, B., Raha, D., Snyder, M., Ren, B. & Wang, W., Apr 2013, In: Nucleic Acids Research. 41, 8, p. 4423-32 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Human Genome 100%
  • Epigenomics 83%
  • Housekeeping 11%
  • Encyclopedias 11%
  • Epigenome 10%
  30 Citations (Scopus)

• Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor

  Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S-H., Lim, H-W., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., Won, K-J. & Lazar, M. A., 26 Dec 2013, In: Molecular Cell. 52, 6, p. 769-82 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Co-Repressor Proteins 100%
  • Histone Deacetylases 91%
  • Liver 40%
  • Histones 36%
  • Genes 31%
  141 Citations (Scopus)

• Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells

  Xie, R., Everett, L. J., Lim, H-W., Patel, N. A., Schug, J., Kroon, E., Kelly, O. G., Wang, A., D'Amour, K. A., Robins, A. J., Won, K-J., Kaestner, K. H. & Sander, M., 7 Feb 2013, In: Cell Stem Cell. 12, 2, p. 224-37 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endocrine Cells 100%
  • Human Embryonic Stem Cells 99%
  • Chromatin Assembly and Disassembly 96%
  • Transcriptome 75%
  • Chromatin 73%
  153 Citations (Scopus)

• EBF2 determines and maintains brown adipocyte identity

  Rajakumari, S., Wu, J., Ishibashi, J., Lim, H-W., Giang, A-H., Won, K-J., Reed, R. R. & Seale, P., 2 Apr 2013, In: Cell Metabolism. 17, 4, p. 562-74 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brown Adipocytes 100%
  • White Adipocytes 62%
  • B-Lymphocytes 54%
  • Brown Adipose Tissue 34%
  • Binding Sites 21%
  207 Citations (Scopus)

• Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

  Alenghat, T., Osborne, L. C., Saenz, S. A., Kobuley, D., Ziegler, C. G. K., Mullican, S. E., Choi, I., Grunberg, S., Sinha, R., Wynosky-Dolfi, M., Snyder, A., Giacomin, P. R., Joyce, K. L., Hoang, T. B., Bewtra, M., Brodsky, I. E., Sonnenberg, G. F., Bushman, F. D., Won, K-J., Lazar, M. A., & 1 othersArtis, D., 5 Dec 2013, In: Nature. 504, 7478, p. 153-7 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • histone deacetylase 3 100%
  • Homeostasis 44%
  • Epithelial Cells 43%
  • Bacteria 41%
  • Paneth Cells 17%
  130 Citations (Scopus)