Jens Lykkesfeldt

Research output

Research output per year 1991 2013 2014 2015 2016 2017 2018 2020

• 170 Journal article
• 10 Review
• 7 Book chapter
• 5 Paper
• 14 More
  • 3 Poster
  • 2 Comment/debate
  • 2 Conference abstract in journal
  • 1 Doctoral thesis
  • 1 Article in proceedings
  • 1 Conference abstract in proceedings
  • 1 Conference abstract for conference
  • 1 Editorial
  • 1 Letter
  • 1 Net publication - Internet publication

Research output per year

Research output per year

Search results

• 2005

  Age-dependent change in Vitamin C status: a phenomenon of matruration rather than of ageing

  Lykkesfeldt, J. & Moos, T., 2005, In: Mechanisms of Ageing and Development. 126, 8, p. 892-898 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  31 Citations (Scopus)

• Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia

  Lauritzen, B., Lykkesfeldt, J., Djurup, R., Flodgaard, H. & Svendsen, O., 2005, In: Pharmacological Research. 51, 6, p. 509-514 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  3 Citations (Scopus)

• Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable?

  Schmitt, B., Finckh, B., Christen, S., Lykkesfeldt, J., Schmid, E. R., Bauersfeld, U., Critelli, H., Hajnal, B. L., Gessler, P. & Molinari, L., 2005, In: Pediatric Research. 58, 4, p. 771-778 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  10 Citations (Scopus)

• Evaluation of a single dose versus a divided dose regimen of amoxycillin in treatment of Actinobacillus pleuropneumoniae infection in pigs

  Lauritzen, B., Lykkesfeldt, J. & Friis, C., 2005, In: Research in Veterinary Science. 79, 1, p. 61-67 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  11 Citations (Scopus)

• Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation

  Christen, S., Finckh, B., Lykkesfeldt, J., Gessler, P., Frese-Schaper, M., Nielsen, P., Schmid, E. R. & Schmitt, B., 2005, In: Free Radical Biology & Medicine. 38, 10, p. 1323-1332 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  89 Citations (Scopus)

• Vitamin C: as biomarker and treatment of oxidative stress caused by smoking : methodological and clinical studies

  Lykkesfeldt, J., 2005, Copenhagen: Center for Skov, Landskab og Planlægning/Københavns Universitet. 59 p.

  Research output: Book/Report › Doctoral thesis
• 2004

  Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone

  Böttcher, T., Ren, H., Goiny, M., Gerber, J., Lykkesfeldt, J., Kuhnt, U., Lotz, M., Bunkowski, S., Werner, C., Schau, I., Spreer, A., Christen, S. & Nau, R., 2004, In: Journal of Neurochemistry. 91, 6, p. 1450-1460 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  32 Citations (Scopus)

• Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men 1-3

  Turnlund, J. R., Jacob, R. A., Keen, C. L., Strain, J. J., Kelly, D. S., Domek, J. M., Keyes, W. R., Ensunsa, J. L., Lykkesfeldt, J. & Coulter, J., 2004, In: American Journal of Clinical Nutrition. 79, 6, p. 1037-1044 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  96 Citations (Scopus)

• Optimized treatment regimens for enrofloxacin in pigs limits selection for resistance in salmonella and coliforms

  Wiuff, C., Lykkesfeldt, J., Aarestrup, F. M. & Svendsen, O., 2004. 1 p.

  Research output: Contribution to conference › Paper › Research

• Pharmacokinetics of amoxicillin after oral administration in recently weaned piglets with experimentally induced Escherichia coli subtype O149:F4 diarrhea

  Jensen, G. M., Lykkesfeldt, J., Frydendahl, K., Møller, K. & Svendsen, O., 2004, In: American Journal of Veterinary Research. 65, p. 992-995 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  11 Citations (Scopus)

• Plasma malondialdehyde is induced by smoking: a study with balanced antioxidant profiles

  Lykkesfeldt, J., Viscovich, M. & Poulsen, H. E., 2004, In: British Journal of Nutrition. 92, 2, p. 203-206 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  27 Citations (Scopus)

• Vitamin C and oxidative damage to DNA: chapter 11

  Poulsen, H. E., Møller, P., Lykkesfeldt, J., Weimann, A. & Loft, S., 2004, Vitamin C. Asard, H., May, J. M. & Smirnoff, N. (eds.). Oxford: BIOS Scientific Publishers, p. 189-202 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Vitamin C pharmacokinetics of plain and slow release formulations in smokers

  Viscovich, M., Lykkesfeldt, J. & Poulsen, H. E., 2004, In: Clinical Nutrition. 23, 5, p. 1043-1050 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)

• Vitamin C supplementation decreases oxidative DNA damage in mononuclear bood cells of smokers

  Møller, P., Viscovich, M., Lykkesfeldt, J., Loft, S., Jensen, A. & Poulsen, H. E., 2004, In: European Journal of Nutrition. 43, p. 267-274 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  77 Citations (Scopus)
• 2003

  Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo

  Lykkesfeldt, J., Viscovich, M. & Poulsen, H. E., 2003, In: Free Radical Biology & Medicine. 11, 11, p. 1439-1447 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  49 Citations (Scopus)

• Effect of smoking on erythorbic acid pharmacokinetics

  Lykkesfeldt, J., Bolbjerg, M. L. & Poulsen, H. E., 2003, In: British Journal of Nutrition. 89, 5, p. 667-671 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  8 Citations (Scopus)

• Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs

  Lauritzen, B., Lykkesfeldt, J. & Friis, C., 2003, In: Research in Veterinary Science. 74, 3, p. 271-277 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  23 Citations (Scopus)

• Putative biomarkers for evaluating antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection

  Lauritzen, B., Lykkesfeldt, J., Skaanild, M. T., Angen, Ø., Nielsen, J. P. & Friis, C., 2003, In: Research in Veterinary Science. 74, 3, p. 261-270 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  57 Citations (Scopus)

• The effects of oral and intramuscular administration and dose escalation of enrofloxacin on the selection of quinolone resistance among Salmonella and coliforms in pigs

  Wiuff, C., Lykkesfeldt, J., Svendsen, O. & Aarestrup, F. M., 2003, In: Research in Veterinary Science. 75, 3, p. 185-193 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  61 Citations (Scopus)
• 2002

  Biomarkers in evaluation of antibiotic treatment: an experimental model of porcine Actinobacillus pleuropneumoniae infection

  Lauritzen, B., Lykkesfeldt, J., Angen, Ø., Nielsen, J. P. & Friis, C., 2002.

  Research output: Contribution to conference › Paper › Research

• Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis

  Schaper, M., Gergely, S., Lykkesfeldt, J., Zbären, J., Leib, S. L., Täuber, M. G. & Christen, S., 2002, In: Journal of Neuropathology and Experimental Neurology. 61, 7, p. 605-613 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  31 Citations (Scopus)

• Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations

  Wiuff, C., Lykkesfeldt, J., Aarestrup, F. M. & Svendsen, O., 2002, In: Journal of Veterinary Pharmacology and Therapeutics. 25, 5, p. 335-342 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  46 Citations (Scopus)

• Evaluation of a single dose and a split-dose regimen of danofloxacin against Actinobacillus pleuropneumoniae infection in pigs

  Lauritzen, B., Lykkesfeldt, J. & Friis, C., 2002.

  Research output: Contribution to conference › Paper › Research

• Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

  Hagen, T. M., Liu, J., Lykkesfeldt, J., Wehr, C. M., Ingersoll, R. T., Vinarsky, V., Bartholomew, J. C. & Ames, B. N., 2002, In: Proceedings of the National Academy of Science of the United States of America. 99, 4, p. 1870-1875 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  261 Citations (Scopus)

• Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation

  Jiang, Q., Lykkesfeldt, J., Shigenaga, M. K., Shigeno, E. T., Christen, S. & Ames, B. N., 2002, In: Free Radical Biology & Medicine. 33, 11, p. 1534-1542 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  104 Citations (Scopus)

• Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigs

  Lykkesfeldt, J., 2002, In: Free Radical Research. 36, 5, p. 567-574 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  34 Citations (Scopus)

• Measurement of ascorbic acid and dehydroascorbic acid in biological samples

  Lykkesfeldt, J., 2002, Current protocols in toxicology. Maines, M., Costa, L. G., Hodson, E., Reed, D. J. & Sipes, I. G. (eds.). New York: Wiley, p. 7.6.1-7.6.15 15 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  19 Citations (Scopus)
• 2001

  Determination of malondialdehyde as dithiobarbituric acid adduct in biological samples by HPLC with fluorescence detection: comparison with ultraviolet-visible spectrophotometry

  Lykkesfeldt, J., 2001, In: Clinical Chemistry. 47, 9, p. 1725-1727 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  181 Citations (Scopus)

• Determination of the disappearance rate of iodine-125 labelled oils from the injection site after intramuscular and subcutaneous administration to pigs

  Weng Larsen, S., Reinvar, E., Svendsen, O., Lykkesfeldt, J., Friis, G. J. & Larsen, C., 2001, In: Internation Journal of Pharmaceutics. 230, p. 67-75 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  12 Citations (Scopus)

• Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment

  Christen, S., Schaper, M., Lykkesfeldt, J., Siegenthaler, C., Bifrare, Y-D., Banic, S. O., Leib, S. L. & Täuber, M. G., 2001, In: Free Radical Biology & Medicine. 31, 6, p. 754-762 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  50 Citations (Scopus)
• 2000

  Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes

  Lykkesfeldt, J., Christen, S., Wallock, L. M., Chang, H. H., Jacob, R. A. & Ames, B. N., 2000, In: American Journal of Clinical Nutrition. 71, p. 530-6 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  180 Citations (Scopus)

• Biochemical markers as indicators of the efficiency of antibiotic treatment of Actinobacillus pleuropneumoniae infection in pigs

  Lauritsen, B., Lykkesfeldt, J., Angen, Ø. & Friis, C., 2000. 1 p.

  Research output: Contribution to conference › Paper › Research

• Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride

  Lykkesfeldt, J., 2000, In: Analytical Biochemistry. 282, p. 89-93 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  209 Citations (Scopus)

• Morphine concentration in plasma andcerebrospinal fluid in the anaesthetised pig after a single intravenous administration

  Lykkegaard, K., Lykkesfeldt, J. & Svendsen, O., 2000. 1 p.

  Research output: Contribution to conference › Paper › Research

• On the possible connection between vitamin C, cardiovirus and guinea pig lameness

  Clausen, F. B., Lykkesfeldt, J. & Kornerup Hansen, A., 2000, Ikke angivet. Laboratory Animals Ltd, p. 101-104 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
• 1999

  (R)-alfa-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

  Hagen, T. M., Ingersoll, R. T., Lykkesfeldt, J., Liu, J., Wehr, C. M., Vinarsky, V., Bartholomew, J. C. & Ames, B. N., 1999, In: The FASEB Journal. 13, p. 411-4418 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

  Hagen, T. M., Ingersoll, R. T., Lykkesfeldt, J., Liu, J., Wehr, C. M., Vinarsky, V., Bartholomew, J. C. & Ames, B. N., 16 Feb 1999, In: FASEB Journal. 13, 2, p. 411-418 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • (R)-Lipoic Acid 100%
  • Thioctic Acid 67%
  • Metabolic 41%
  • Membrane Potential 13%
  • Mitochondrial Membrane Potential 13%
  250 Citations (Scopus)

• Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: decline with age

  Lykkesfeldt, J. & Ames, B. N., 1999, In: Methods in Enzymology. 299, p. 83-88 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: decline with age

  Lykkesfeldt, J. & Ames, B. N., 1999, Oxidants and antioxidants part A. Packer, L. (ed.). San Diego: Academic Press, Vol. 299. p. 83-88 6 p. (Methods in Enzymology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  10 Citations (Scopus)
• 1998

  Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

  Hagen, T. M., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song, M-H. & Ames, B. N., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, p. 9562-9566 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  227 Citations (Scopus)

• Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes: reversal with (R)-alfa-lipoic acid supplementation

  Lykkesfeldt, J., Hagen, T. M., Vinarsky, V. & Ames, B. N., 1998, In: The FASEB Journal. 12, p. 1183-1189 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  130 Citations (Scopus)

• Artemisinin induces omeprazole metabolism in human beings

  Svensson, U. S. H., Ashton, M., Hai, T. N., Bertilsson, L., Huong, D. X., Van Huong, N., Niêu, N. T., Sy, N. D., Lykkesfeldt, J. & Công, L. D., 1 Aug 1998, In: Clinical Pharmacology and Therapeutics. 64, 2, p. 160-167 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • artemisinine 100%
  • Omeprazole 93%
  • Cytochrome P-450 CYP2C19 56%
  • 5-hydroxymethylomeprazole 48%
  • omeprazole sulfone 33%
  74 Citations (Scopus)

• Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: Decline with age

  Lykkesfeldt, J. & Ames, B. N., 3 Nov 1998, In: Methods in Enzymology. 299, p. 83-88 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Oxidative DNA damage in vivo: relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion

  Poulsen, H. E., Loft, S., Prieme, H., Vistisen, K., Lykkesfeldt, J., Nyyssonen, K. & Salonen, J. T., 1998, In: Free Radical Research. 29, p. 565-571 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  90 Citations (Scopus)

• Oxidative DNA damage in vivo: Relationship to age, plasma antioxidants, drug metabolism, glutathione-S-transferase activity and urinary creatinine excretion

  Poulsen, H. E., Loft, S., Prieme, H., Vistisen, K. K., Lykkesfeldt, J., Nyyssonen, K. & Salonen, J. T., 1998, In: Free Radical Research. 29, p. 565-571

  Research output: Contribution to journal › Journal article › Research › peer-review

  90 Citations (Scopus)
• 1997

  Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking, 1-3

  Lykkesfeldt, J., Loft, S., Nielsen, J. B. & Poulsen, H. E., 1997, In: American Journal of Clinical Nutrition. 65, p. 959-963

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1996

  Effect of smoking cessation on plasma ascorbic acid concentration

  Lykkesfeldt, J., Priemé, H., Loft, S. & Poulsen, H. E., 13 Jul 1996, In: B M J (Clinical Research Edition). 313, 7049, p. 91

  Research output: Contribution to journal › Journal article › Research › peer-review

  71 Citations (Scopus)
• 1995

  Determination of Ascorbic Acid and Dehydroascorbic Acid in Plasma by High-Performance Liquid Chromatography with Coulometric Detection - Are They Reliable Biomarkers of Oxidative Stress?

  Lykkesfeldt, J., Loft, S. & Poulsen, H. E., 1995, In: Analytical Biochemistry. 229, p. 329-335

  Research output: Contribution to journal › Journal article › Research › peer-review

  175 Citations (Scopus)

• Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic acid-induced seedlings of Sinapis alba L.

  Du, L., Lykkesfeldt, J., Olsen, C. E. & Halkier, B. A., 19 Dec 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 26, p. 12505-12509 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sinapis 100%
  • jasmonic acid 94%
  • Glucosinolates 84%
  • Seedlings 80%
  • Oximes 72%
  66 Citations (Scopus)

• Involvment of cytochrome P450 in Oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomale enzyme system isolated from jasmonic acid-induced seedlings of Sinapis alba

  Du, L., Lykkesfeldt, J., Olsen, C. E. & Halkier, B. A., 1995, In: Proceedings of the National Academy of Science of the United States of America. 92, 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review