Ivana Novak

2020

Pannexin-1 mediated ATP release in adipocytes is sensitive to glucose and insulin and modulates lipolysis and macrophage migration

Tozzi, M., Hansen, J. B. & Novak, I., 1 Feb 2020, In: Acta Physiologica. 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2019

Role of the P2X7 receptor in the pathogenesis of type 2 diabetes and its microvascular complications

Solini, A. & Novak, I., 2019, In: Current Opinion in Pharmacology. 47, p. 75-81 7 p.

Research output: Contribution to journal › Review › peer-review

13 Citations (Scopus)

2018

Deconstructing the principles of ductal network formation in the pancreas

Dahl-Jensen, S. B., Yennek, S., Flasse, L., Larsen, H. L., Sever, D., Karremore, G., Novak, I., Sneppen, K. & Botton, A., 26 Jul 2018, In: PLOS Biology. 16, 7, 25 p., e2002842.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

80 Downloads (Pure)

P2X receptor-ion channels in the inflammatory response in adipose tissue and pancreas-potential triggers in onset of type 2 diabetes?

Novak, I. & Solini, A., Jun 2018, In: Current Opinion in Immunology. 52, p. 1-7 7 p.

Research output: Contribution to journal › Review › peer-review

16 Citations (Scopus)

The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells

Tozzi, M., Larsen, A. T., Lange, S. C., Giannuzzo, A., Andersen, M. N. & Novak, I., 1 Dec 2018, In: Scientific Reports. 8, 15 p., 8926.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

64 Downloads (Pure)

2017

Alternating pH landscapes shape epithelial cancer initiation and progression: focus on pancreatic cancer

Pedersen, S. H. F., Novak, I., Alves, F., Schwab, A. & Pardo, L. A., Jun 2017, In: BioEssays. 39, 6, 10 p., 1600253.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Ion channels in control of pancreatic stellate cell migration

Storck, H., Hild, B., Schimmelpfennig, S., Sargin, S., Nielsen, N., Zaccagnino, A., Budde, T., Novak, I., Kalthoff, H. & Schwab, A., 3 Jan 2017, In: OncoTarget. 8, 1, p. 769-784 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

255 Downloads (Pure)

Normal and malignant cells exhibit differential responses to calcium electroporation

Frandsen, S. K., Krüger, M. B., Mangalanathan, U. M., Tramm, T., Mahmood, F., Novak, I. & Gehl, J., 15 Aug 2017, In: Cancer Research. 77, 16, p. 4389-4401 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Purinergic receptors in adipose tissue as potential targets in metabolic disorders

Tozzi, M. & Novak, I., 24 Nov 2017, In: Frontiers in Pharmacology. 8, 8 p., 878.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

65 Downloads (Pure)

2016

ATP signals

Novak, I., 2016, In: PEN: Science & Technology. 2016, 21, p. 174-174 1 p.

Research output: Contribution to journal › Comment/debate › Communication

Difference in membrane repair capacity between cancer cell lines and a normal cell line

Frandsen, S. K., McNeil, A. K., Novak, I., McNeil, P. L. & Gehl, J., 1 Aug 2016, In: Journal of Membrane Biology. 249, 4, p. 569-576 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

82 Downloads (Pure)

Fundamentals of bicarbonate secretion in epithelia

Novak, I. & Prætorius, J., 2016, Ion channels and transporters of epithelia in health and disease. Hamilton, K. L. & Devor, D. C. (eds.). New York, NY: Springer, p. 187-263 77 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Identification of K_Ca3.1 channel as a novel regulator of Oxidative phosphorylation in a subset of pancreatic carcinoma cell lines

Kovalenko, I., Glasauer, A., Schöckel, L., Sauter, D. R. P., Ehrmann, A., Sohler, F., Hägebarth, A., Novak, I. & Christian, S., Aug 2016, In: P L o S One. 11, 8, 20 p., e0160658.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

106 Downloads (Pure)

In silico analysis of the transportome in human pancreatic ductal adenocarcinoma

Zaccagnino, A., Pilarsky, C., Tawfik, D., Sebens, S., Trauzold, A., Novak, I., Schwab, A. & Kalthoff, H., 1 Oct 2016, In: European Biophysics Journal. 45, 7, p. 749-763 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

K_Ca3.1 (IK) modulates pancreatic cancer cell migration, invasion and proliferation: anomalous effects on TRAM-34

Bonito, B., Sauter, D. R. P., Schwab, A., Djamgoz, M. B. A. & Novak, I., 1 Nov 2016, In: Pfluegers Archiv. 468, 11, p. 1865-1875 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Monocarboxylate transporters MCT1 and MCT4 regulate migration and invasion of pancreatic ductal adenocarcinoma cells

Kong, S. C., Nøhr-Nielsen, A., Zeeberg, K., Reshkin, S. J., Hoffmann, E. K., Novak, I. & Pedersen, S. H. F., 1 Aug 2016, In: Pancreas. 45, 7, p. 1036-1047 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

pH-sensitive K⁺ channel TREK-1 is a novel target in pancreatic cancer

Sauter, D. R. P., Sørensen, C. E., Rapedius, M., Brüggemann, A. & Novak, I., 1 Oct 2016, In: B B A - Molecular Basis of Disease. 1862, 10, p. 1994-2003 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

141 Downloads (Pure)

Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

Giannuzzo, A., Saccomano, M., Napp, J., Ellegaard, M., Alves, F. & Novak, I., 1 Dec 2016, In: International Journal of Cancer. 139, 11, p. 2540-2552 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

136 Downloads (Pure)

The adenosine A_2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells

Hayashi, M., Inagaki, A., Novak, I. & Matsuda, H., 1 Jul 2016, In: Pfluegers Archiv. 468, 7, p. 1171-1181 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

57 Downloads (Pure)

2015

ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC)

Sauter, D. R. P., Novak, I., Pedersen, S. H. F., Larsen, E. H. & Hoffmann, E. K., 13 Jul 2015, In: Pflügers Archiv - European Journal of Physiology. 467, 7, p. 1495-1508 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

60 Citations (Scopus)

757 Downloads (Pure)

ATP release, generation and hydrolysis in exocrine pancreatic duct cells

Kowal, J. M., Yegutkin, G. G. & Novak, I., 1 Dec 2015, In: Purinergic Signalling. 11, 4, p. 533-550 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells

Kowal, J. M., Haanes, K. A., Christensen, N. & Novak, I., 9 Jun 2015, In: Cell Communication and Signaling. 13, 16 p., 28 .

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

160 Downloads (Pure)

Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction

Kringelbach, T. M., Aslan, D., Novak, I., Ellegaard, M., Syberg, S., Andersen, C. K. B., Kristiansen, K. A., Vang, O., Schwarz, P. & Jørgensen, N. R., 1 Dec 2015, In: Cellular Signalling. 27, 12, p. 2401-2409 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Proton pump inhibitors inhibit pancreatic secretion: role of gastric and non-gastric H+/K+-ATPases

Wang, J., Barbuskaite, D., Tozzi, M., Giannuzzo, A., Sørensen, C. E. & Novak, I., 18 May 2015, In: PloS one. 10, 5, 20 p., e0126432.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

130 Downloads (Pure)

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

Giannuzzo, A., Pedersen, S. H. F. & Novak, I., 25 Nov 2015, In: Molecular Cancer. 14, 15 p., 203.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

92 Downloads (Pure)

2014

Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential [Plus] Corrigendum

Kong, S. C., Giannuzzo, A., Novak, I. & Pedersen, S. H. F., 17 Aug 2014, In: Biochemistry and Cell Biology. 92, 6, p. 449-459 11 p.

Research output: Contribution to journal › Review › peer-review

26 Citations (Scopus)

Role of vesicular nucleotide transporter VNUT (SLC₁₇A₉) in release of ATP from AR₄₂J cells and mouse pancreatic acinar cells

Haanes, K. A., Kowal, J. M., Arpino, G., Lange, S. C., Moriyama, Y., Pedersen, P. A. & Novak, I., Sept 2014, In: Purinergic Signalling. 10, 3, p. 431-440 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

UTP-induced ATP release is a fine-tuned signalling pathway in osteocytes

Kringelbach, T. M., Aslan, D., Novak, I., Schwarz, P. & Jørgensen, N. R., Jun 2014, In: Purinergic Signalling. 10, 2, p. 337-347 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

2013

Acid-base transport in pancreas-new challenges

Novak, I., Haanes, K. A. & Wang, J., 2013, In: Frontiers in Physiology. 4, 7 p., 380.

Research output: Contribution to journal › Review › peer-review

21 Citations (Scopus)

766 Downloads (Pure)

Cell volume regulation in epithelial physiology and cancer

Pedersen, S. H. F., Hoffmann, E. K. & Novak, I., 2013, In: Frontiers in Physiology. 4, 12 p., 233.

Research output: Contribution to journal › Review › peer-review

1846 Downloads (Pure)

Ion Transport in Human Pancreatic Duct Epithelium, Capan-1 Cells, Is Regulated by Secretin, VIP, Acetylcholine, and Purinergic Receptors

Wang, J. & Novak, I., Apr 2013, In: Pancreas. 42, 3, p. 452-460 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Molecular basis of potassium channels in pancreatic duct epithelial cells

Hayashi, M. & Novak, I., 2013, In: Channels (Austin). 7, 6, p. 432-441 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

1001 Downloads (Pure)

Purinergic regulation of CFTR and Ca²⁺ -activated C^l- channels and K⁺ channels in human pancreatic duct epithelium

Wang, J., Haanes, K. A. & Novak, I., 1 Apr 2013, In: American Journal of Physiology: Cell Physiology. 304, 7, p. C673-84 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Purinergic signalling and diabetes

Burnstock, G. & Novak, I., Sept 2013, In: Purinergic Signalling. 9, 3, p. 307-324 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

73 Citations (Scopus)

Purinergic signalling - a possible mechanism for KCNQ1 channel response to cell volume challenges

Bomholtz, S. H., Willumsen, N. J., Meinild, A.-K., Klærke, D. A. & Novak, I., Mar 2013, In: Acta Physiologica (Print). 207, 3, p. 503-515 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

The cystic fibrosis of exocrine pancreas

Wilschanski, M. & Novak, I., May 2013, In: Cold Spring Harbor Perspectives in Medicine. 3, 5, p. 1-17 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

71 Citations (Scopus)

2012

An intermediate-conductance Ca²⁺-activated K⁺ channel is important for secretion in pancreatic duct cells

Hayashi, M., Wang, J., Hede, S. E. & Novak, I., 15 Jul 2012, In: American Journal of Physiology: Cell Physiology. 303, 2, p. C151-C159 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

Elevated ammonium levels: differential acute effects on three glutamate transporter isoforms

Søgaard, R., Novak, I. & MacAulay, N., Mar 2012, In: American Journal of Physiology: Cell Physiology. 302, 6, p. C880-C891 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Purinergic signalling in the pancreas in health and disease

Burnstock, G. & Novak, I., May 2012, In: Journal of Endocrinology. 213, 2, p. 123-41 19 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

The P2X7 Receptor Supports Both Life and Death in Fibrogenic Pancreatic Stellate Cells

Haanes, K., Schwab, A. & Novak, I., 17 Dec 2012, In: P L o S One. 7, 12, 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

465 Downloads (Pure)

UTP and mechanical stimulation induce ATP release from osteocytes

Kringelbach, T. M., Novak, I., Bonewald, L. F., Vang, O., Schwarz, P. & Jørgensen, N. R., 2012, In: Bone. 50, Supplement 1, p. S95

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

2011

Cell Volume Regulation and Signaling in 3T3-L1 Pre-adipocytes and Adipocytes: on the Possible Roles of Caveolae, Insulin Receptors, FAK and ERK1/2

Eduardsen, K., Larsen, S., Novak, I., Lambert, I. H., Hoffmann, E. K. & Pedersen, S. H. F., 2011, In: Cellular Physiology and Biochemistry. 28, 6, p. 1231-46 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Pancreatic bicarbonate secretion involves two proton pumps

Novak, I., Wang, J., Henriksen, K. L., Haanes, K. A., Krabbe, S., Nitschke, R. & Hede, S. E., 7 Jan 2011, In: Journal of Biological Chemistry. 286, 1, p. 280-289 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Purinergic signalling in epithelial ion transport: regulation of secretion and absorption

Novak, I., Jul 2011, In: Acta Physiologica. 202, 3, p. 501-22 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

2010

ATP storage and uptake by isolated pancreatic zymogen granules

Haanes, K. A. & Novak, I., 15 Jul 2010, In: Biochemical Journal. 429, 2, p. 303-311 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

ATP storage and uptake in isolated pancreatic zymogen granules

Haanes, K. A. & Novak, I., 15 Jul 2010, In: Purinergic Signalling. Suppl. 1, p. 12 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

47 Citations (Scopus)

Effect of P2X(7) receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands

Novak, I., Jans, I. M. & Wohlfahrt, L., 15 Sept 2010, In: Journal of Physiology. 588, Pt 18, p. 3615-27 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Ion transport proteins control pancreatic cancer cell behaviour

Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R. D., Pedersen, S. H. F., Andersen, A.-D., Hoffmann, E. K., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., Borowiec, A. S., Arcangeli, A., Zanieri, F., D´Amico, M., Fraser, S. P., Djamgoz, M. B., Alves, F. & Kalthoff, H. & 2 others, Pardo, L. A. & Stühmer, W., 2010, In: Acta Physiologica (Print Edition). 198, 677, p. 17 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Ion transport proteins control pancreatic ductal adenocarcinoma

Schwab, A., Stock, C., Swietach, P., Hulikova, A., Vaughan-Jones, R., Pedersen, S. H. F., Andersen, A. D., Hoffmann, E., Novak, I., Reshkin, S., Prevarskaya, N., Lemonnier, L., A-S, B., Fraser, S. P., Arcangeli, A., Zanieri, F., D'Amico, M., Kalthoff, H., Djamgoz, M. B. & Alves, F. & 2 others, Pardo, L. & Stuehmer, W., 1 Oct 2010, In: Onkologie. 33, Suppl. 6, p. 269 1 p.

Research output: Contribution to journal › Journal article › Research › peer-review

KCNQ1 channel response to cell volume changes is not mediated by ATP release

Hammami, S., Willumsen, N., Novak, I. & Klærke, D. A., 2010, In: Acta Physiologica Scandinavica. Supplementum. 198, Suppl 677, p. 213 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Ivana Novak

Research output

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