Research output per year
Research output per year
Personal profile
Primary fields of research
Neuroinflammation, Neurodegeneration, Parkinson's disease
Short presentation
Originally from Vancouver, Canada, Erika obtained her BSc in Honours Health Studies from the University of Waterloo in 2008. She continued to earn her MSc in Biology from the University of British Columbia Okanagan in 2011 under the supervision of Dr. Andis Klegeris on a project characterizing the impact of a glial secreted proinflammatory phospholipase on neuronal health. From 2012 to 2015, Erika worked as a research technician in the laboratory of Dr. Michael Hayden characterizing several preclinical mouse models of Huntington’s disease.
In 2016, Erika moved to Copenhagen, Denmark, to join Prof. Shohreh Issazadeh-Navikas’ group as a PhD candidate. Her current projects investigate the impact of defective type I interferon signaling on the development of spontaneous synucleinopathy and aging-related neurodegeneration in mice, with the aim of identifying potential novel therapeutic targets for Parkinson’s disease and other neurodegenerative disorders involving neuroinflammation and proteinopathies.
Education/Academic qualification
Characterizing the role of secretory phospholipase A2 group IIA in glial cell-mediated neurotoxicity, Department of Biology, University of British Columbia Okanagan
2 Jan 2009 → 30 Apr 2011
Award Date: 30 Apr 2011
External positions
Centre for Molecular Medicine and Therapeutics at BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.
5 Feb 2012 → 15 Dec 2015
Keywords
- BRIC
- Neuroinflammation
- Neurodegeneration
- Parkinson's disease
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- 4 Similar Profiles
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ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT
Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, E. B., Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., Sept 2018, p. A91-A91.Research output: Contribution to conference › Poster › Research
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HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 Jan 2018, In: Human Molecular Genetics. 27, 2, p. 239-253 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W. & Swayze, E. E. & 2 others, , 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides
Southwell, A. L., Skotte, N. H., Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, E. B., Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., 11 Dec 2014, In: Molecular Therapy. 22, 12, p. 2093-106 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A fully humanized transgenic mouse model of Huntington disease
Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, N. H., Zhang, W., Villanueva, E. B., Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 Jan 2013, In: Human Molecular Genetics. 22, 1, p. 18-34 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, N. H., Doty, C. N., Vaid, K., Villanueva, E. B., Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., Nov 2013, In: Nucleic Acids Research. 41, 21, p. 9634-50 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells
Villanueva, E. B., Little, J. P., Lambeau, G. & Klegeris, A., Apr 2012, In: Molecular and Cellular Neuroscience.Research output: Contribution to journal › Journal article › Research › peer-review