Publikationer pr. år
Publikationer pr. år
Personlig profil
Primære forskningsområder
Neuroinflammation, Neurodegeneration, Parkinson's disease
Kort præsentation
Originally from Vancouver, Canada, Erika obtained her BSc in Honours Health Studies from the University of Waterloo in 2008. She continued to earn her MSc in Biology from the University of British Columbia Okanagan in 2011 under the supervision of Dr. Andis Klegeris on a project characterizing the impact of a glial secreted proinflammatory phospholipase on neuronal health. From 2012 to 2015, Erika worked as a research technician in the laboratory of Dr. Michael Hayden characterizing several preclinical mouse models of Huntington’s disease.
In 2016, Erika moved to Copenhagen, Denmark, to join Prof. Shohreh Issazadeh-Navikas’ group as a PhD candidate. Her current projects investigate the impact of defective type I interferon signaling on the development of spontaneous synucleinopathy and aging-related neurodegeneration in mice, with the aim of identifying potential novel therapeutic targets for Parkinson’s disease and other neurodegenerative disorders involving neuroinflammation and proteinopathies.
Uddannelse (Akademiske kvalifikationer)
Characterizing the role of secretory phospholipase A2 group IIA in glial cell-mediated neurotoxicity, Department of Biology, University of British Columbia Okanagan
2 jan. 2009 → 30 apr. 2011
Dimissionsdato: 30 apr. 2011
Eksterne ansættelser
Centre for Molecular Medicine and Therapeutics at BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.
5 feb. 2012 → 15 dec. 2015
Emneord
- BRIC
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Erika Villanueva er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 4 Lignende profiler
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ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT
Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, E. B., Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., sep. 2018, s. A91-A91.Publikation: Konferencebidrag › Poster › Forskning
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HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 jan. 2018, I: Human Molecular Genetics. 27, 2, s. 239-253 15 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, I: Science Translational Medicine. 10, 461, s. 1-12 eaar3959.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W. & Swayze, E. E. & 2 flere, , 15 mar. 2017, I: Human Molecular Genetics. 26, 6, s. 1115-1132 18 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides
Southwell, A. L., Skotte, N. H., Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, E. B., Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., 11 dec. 2014, I: Molecular Therapy. 22, 12, s. 2093-106 14 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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A fully humanized transgenic mouse model of Huntington disease
Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, N. H., Zhang, W., Villanueva, E. B., Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 jan. 2013, I: Human Molecular Genetics. 22, 1, s. 18-34 17 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, N. H., Doty, C. N., Vaid, K., Villanueva, E. B., Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., nov. 2013, I: Nucleic Acids Research. 41, 21, s. 9634-50 17 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells
Villanueva, E. B., Little, J. P., Lambeau, G. & Klegeris, A., apr. 2012, I: Molecular and Cellular Neuroscience.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review