Andrea Heinz

2019

A comprehensive map of human elastin cross-linking during elastogenesis

Hedtke, T., Schräder, C. U., Heinz, A., Hoehenwarter, W., Brinckmann, J., Groth, T. & Schmelzer, C. E. H., 1 Sept 2019, In: The F E B S Journal (Online).

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex

Kawecki, C., Bocquet, O., Schmelzer, C. E. H., Heinz, A., Ihling, C., Wahart, A., Romier, B., Bennasroune, A., Blaise, S., Terryn, C., Linton, K. J., Martiny, L., Duca, L. & Maurice, P., 28 Feb 2019, In: Cellular and molecular life sciences : CMLS. 76, 4, p. 791–807

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

10 Downloads (Pure)

Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin

Schmelzer, C. E. H., Heinz, A., Troilo, H., Lockhart-Cairns, M. P., Jowitt, T. A., Marchand, M. F., Bidault, L., Bignon, M., Hedtke, T., Barret, A., McConnell, J. C., Sherratt, M. J., Germain, S., Hulmes, D. J. S., Baldock, C. & Muller, L., 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5468-5481

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

30 Downloads (Pure)

MMP-14 degrades tropoelastin and elastin

Miekus, N., Luise, C., Sippl, W., Baczek, T., Schmelzer, C. E. H. & Heinz, A., Oct 2019, In: Biochimie.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2018

Degradation of tropoelastin and skin elastin by neprilysin

Mora Huertas, A. C., Schmelzer, C. E. H., Luise, C., Sippl, W., Pietzsch, M., Hoehenwarter, W. & Heinz, A., Mar 2018, In: Biochimie. 146, p. 73-78 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Elastin is heterogeneously cross-linked

Schräder, C. U., Heinz, A., Majovsky, P., Karaman, B., Brinckmann, J., Sippl, W. & Schmelzer, C. E. H., 28 Sept 2018, In: The Journal of Biological Chemistry.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Production of Elastin-Derived Peptides Contribute to the Development of Non-Alcoholic Steatohepatitis

Romier, B., Ivaldi, C., Sartelet, H., Heinz, A., Schmelzer, C. E. H., Garnotel, R., Guillot, A., Jonquet, J., Bertin, E., Guéant, J.-L., Alberto, J.-M., Bronowicki, J.-P., Amoyel, J., Hocine, T., Duca, L., Maurice, P., Bennasroune, A., Martiny, L., Debelle, L. & Durlach, V. & 1 others, Blaise, S., 1 Aug 2018, In: Diabetes.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema

Joshi, R., Heinz, A., Fan, Q., Guo, S., Monia, B., Schmelzer, C. E. H., Weiss, A. S., Batie, M., Parameshwaran, H. & Varisco, B. M., 8 Feb 2018, In: American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 167-178 0361OC .

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2016

Cadmium toxicity investigated at the physiological and biophysical levels under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum

Andresen, E., Kappel, S., Stärk, H.-J., Riegger, U., Borovec, J., Mattusch, J., Heinz, A., Schmelzer, C. E. H., Matoušková, Š., Dickinson, B. & Küpper, H., 1 Jun 2016, In: New Phytologist. 210, 4, p. 1244-58 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Elastins from patients with Williams-Beuren syndrome and healthy individuals differ on the molecular level

Heinz, A., Huertas, A. C. M., Schräder, C. U., Pankau, R., Gosch, A. & Schmelzer, C. E. H., 1 Jul 2016, In: American Journal of Medical Genetics. Part A. 170, 7, p. 1832-42 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Molecular-level insights into aging processes of skin elastin

Mora Huertas, A. C., Schmelzer, C. E. H., Hoehenwarter, W., Heyroth, F. & Heinz, A., 1 Sept 2016, In: Biochimie. 128-129, p. 163-73 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Prolyl hydroxylation in elastin is not random

Schmelzer, C. E. H., Nagel, M. B. M., Dziomba, S., Merkher, Y., Sivan, S. S. & Heinz, A., 1 Oct 2016, In: B B A - Reviews on Cancer. 1860, 10, p. 2169-77 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

2015

Fingerprinting desmosine-containing elastin peptides

Schräder, C. U., Heinz, A., Majovsky, P. & Schmelzer, C. E. H., 1 May 2015, In: Journal of the American Society for Mass Spectrometry. 26, 5, p. 762-73 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms

Bultmann-Mellin, I., Conradi, A., Maul, A. C., Dinger, K., Wempe, F., Wohl, A. P., Imhof, T., Wunderlich, F. T., Bunck, A. C., Nakamura, T., Koli, K., Bloch, W., Ghanem, A., Heinz, A., von Melchner, H., Sengle, G. & Sterner-Kock, A., 1 Apr 2015, In: Disease models & mechanisms. 8, 4, p. 403-15 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2014

Molecular-level characterization of elastin-like constructs and human aortic elastin

Heinz, A., Schräder, C. U., Baud, S., Keeley, F. W., Mithieux, S. M., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., 1 Sept 2014, In: Matrix Biology. 38, p. 12-21 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2013

Elastin-derived peptides are new regulators of insulin resistance development in mice

Blaise, S., Romier, B., Kawecki, C., Ghirardi, M., Rabenoelina, F., Baud, S., Duca, L., Maurice, P., Heinz, A., Schmelzer, C. E. H., Tarpin, M., Martiny, L., Garbar, C., Dauchez, M., Debelle, L. & Durlach, V., Nov 2013, In: Diabetes. 62, 11, p. 3807-16 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

56 Citations (Scopus)

Investigating the role of (2S,4R)-4-hydroxyproline in elastin model peptides

Bochicchio, B., Laurita, A., Heinz, A., Schmelzer, C. E. H. & Pepe, A., 9 Dec 2013, In: Biomacromolecules. 14, 12, p. 4278-88 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials

Heinz, A., Ruttkies, C. K. H., Jahreis, G., Schräder, C. U., Wichapong, K., Sippl, W., Keeley, F. W., Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2013, In: B B A - Reviews on Cancer. 1830, 4, p. 2994-3004 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2012

Does human leukocyte elastase degrade intact skin elastin?

Schmelzer, C. E. H., Jung, M. C., Wohlrab, J., Neubert, R. H. H. & Heinz, A., Nov 2012, In: F E B S Journal. 279, 22, p. 4191-200 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid

Sivan, S.-S., Van El, B., Merkher, Y., Schmelzer, C. E. H., Zuurmond, A.-M., Heinz, A., Wachtel, E., Varga, P.-P., Lazary, A., Brayda-Bruno, M. & Maroudas, A., Oct 2012, In: B B A - Reviews on Cancer. 1820, 10, p. 1671-7 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

The action of neutrophil serine proteases on elastin and its precursor

Heinz, A., Jung, M. C., Jahreis, G., Rusciani, A., Duca, L., Debelle, L., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Jan 2012, In: Biochimie. 94, 1, p. 192-202 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

2011

Insights into the degradation of human elastin by matrilysin-1

Heinz, A., Taddese, S., Sippl, W., Neubert, R. H. H. & Schmelzer, C. E. H., Feb 2011, In: Biochimie. 93, 2, p. 187-94 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

Structure and activity of Aspergillus nidulans copper amine oxidase

McGrath, A. P., Mithieux, S. M., Collyer, C. A., Bakhuis, J. G., van den Berg, M., Sein, A., Heinz, A., Schmelzer, C., Weiss, A. S. & Guss, J. M., 28 Jun 2011, In: Biochemistry. 50, 25, p. 5718-30 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

2010

Degradation of tropoelastin by matrix metalloproteinases--cleavage site specificities and release of matrikines

Heinz, A., Jung, M. C., Duca, L., Sippl, W., Taddese, S., Ihling, C., Rusciani, A., Jahreis, G., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2010, In: F E B S Journal. 277, 8, p. 1939-56 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III

Taddese, S., Jung, M. C., Ihling, C., Heinz, A., Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2010, In: B B A - Reviews on Cancer. 1804, 4, p. 731-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

2009

Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy

Heinz, A., Strachan, C. J., Gordon, K. C. & Rades, T., Aug 2009, In: The Journal of pharmacy and pharmacology. 61, 8, p. 971-88 18 p.

Research output: Contribution to journal › Review › peer-review

153 Citations (Scopus)

Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy

Savolainen, M., Kogermann, K., Heinz, A., Aaltonen, J., Peltonen, L., Strachan, C. & Yliruusi, J., Jan 2009, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 71, 1, p. 71-9 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

115 Citations (Scopus)

Understanding the solid-state forms of fenofibrate - A spectroscopic and computational study

Heinz, A., Gordon, K. C., McGoverin, C. M., Rades, T. & Strachan, C. J., Jan 2009, In: European Journal of Pharmaceutics and Biopharmaceutics. 71, 1, p. 100-108

Research output: Contribution to journal › Journal article › Research › peer-review

2008

Characterizing an amorphous system exhibiting trace crystallinity: A case study with saquinavir

Heinz, A., Strachan, C. J., Atassi, F., Gordon, K. C. & Rades, T., Jan 2008, In: Crystal Growth & Design. 8, 1, p. 119-127

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2007

Quantifying ternary mixtures of different solid-state forms of indomethacin by Raman and near-infrared spectroscopy

Heinz, A., Savolainen, M., Rades, T. & Strachan, C. J., Nov 2007, In: European Journal of Pharmaceutical Sciences. 32, 3, p. 182-192

Research output: Contribution to journal › Journal article › Research › peer-review

Screening for differences in the amorphous state of indomethacin using multivariate visualization

Savolainen, M., Heinz, A., Strachan, C., Gordon, K. C., Yliruusi, J., Rades, T. & Sandler, N., Feb 2007, In: European Journal of Pharmaceutical Sciences. 30, 2, p. 113-123

Research output: Contribution to journal › Journal article › Research › peer-review

Andrea Heinz

Research output

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