Alejandro Aguayo Orozco

Research output

Research output per year 2016 2018 2019 2019

• 6 Journal article
• 1 Review

Research output per year

Research output per year

Search results

• 2019

  A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

  Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Narayanan, D., Baig, A., Zang, J., Aguayo-Orozco, A., Carmona, R., Garcia, A. & Bach, A., 12 Sept 2019, In: Journal of Medicinal Chemistry. 62, 17, p. 8028-8052

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteins 100%
  • Oxidative Stress 89%
  • Surface Plasmon Resonance 86%
  • Disorder 77%
  • Polarization 67%
  28 Citations (Scopus)

• Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

  Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stoeber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., van Thriel, C., Golka, K., Tolosa, L., Castell, J. V., Damm, G., & 28 othersSeehofer, D., Lampen, A., Braeuning, A., Buhrke, T., Behr, A-C., Oberemm, A., Gu, X., Kittana, N., van de Water, B., Kreiling, R., Fayyaz, S., van Aerts, L., Smedsrød, B., Ellinger-Ziegelbauer, H., Steger-Hartmann, T., Gundert-Remy, U., Zeigerer, A., Ullrich, A., Runge, D., Lee, S. M. L., Schiergens, T. S., Kuepfer, L., Aguayo-Orozco, A., Sachinidis, A., Edlund, K., Gardner, I., Rahnenführer, J. & Hengstler, J. G., 1 Jun 2019, In: Archives of Toxicology. 93, 6, p. 1609-1637 29 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemical and Drug Induced Liver Injury 100%
  • Hepatotoxic 84%
  • Peak Plasma Concentration 77%
  • Dose 58%
  • No-Observed-Adverse-Effect Level 51%
  41 Citations (Scopus)

  6 Downloads (Pure)

• sAOP: linking chemical stressors to adverse outcomes pathway networks

  Aguayo-Orozco, A., Audouze, K., Siggaard, T., Barouki, R., Brunak, S. & Taboureau, O., 15 Dec 2019, In: Bioinformatics. 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adverse Outcome Pathways 100%
  • Pathway 71%
  • Linking 63%
  • Toxicological Phenomena 29%
  • Wikis 22%
  5 Citations (Scopus)

  4 Downloads (Pure)

• The use of systems biology in chemical risk assessment

  Aguayo-Orozco, A., Taboureau, O. & Brunak, S., 2019, In: Current Opinion in Toxicology. 15, p. 48-54 7 p.

  Research output: Contribution to journal › Review › peer-review

  • Risk Assessment 100%
  • Systems Biology 98%
  • Adverse Outcome Pathways 68%
  • Toxicology 60%
  • Pharmacologic Actions 29%
  4 Citations (Scopus)

  16 Downloads (Pure)
• 2018

  Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

  Aguayo-Orozco, A., Bois, F. Y., Brunak, S. & Taboureau, O., 2018, In: Frontiers in Genetics. 9, p. 1-15 396.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fatty Liver 100%
  • Gene Expression 84%
  • Adverse Outcome Pathways 77%
  • linolenic acid drug combination linoleic acid 77%
  • Liver 72%
  5 Citations (Scopus)

  101 Downloads (Pure)

• Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

  Grinberg, M., Stöber, R. M., Albrecht, W., Edlund, K., Schug, M., Godoy, P., Cadenas, C., Marchan, R., Lampen, A., Braeuning, A., Buhrke, T., Leist, M., Oberemm, A., Hellwig, B., Kamp, H., Gardner, I., Escher, S., Taboureau, O., Aguayo-Orozco, A., Sachinidis, A., & 3 othersEllinger-Ziegelbauer, H., Rahnenführer, J. & Hengstler, J. G., Dec 2018, In: Archives of Toxicology. 92, 12, p. 3517-3533 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Toxicogenetics 100%
  • Valproic Acid 96%
  • Directories 93%
  • Microarrays 71%
  • Hepatocytes 55%
  24 Citations (Scopus)
• 2016

  In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

  Orozco, A. A., Audouze, K., Brunak, S. & Taboureau, O., 1 Dec 2016, In: Current Pharmaceutical Design. 22, 46, p. 6895-6902 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Computer Simulation 100%
  • Therapeutic Uses 87%
  • Toxic 79%
  • Poisons 78%
  • Pharmacology 70%
  2 Citations (Scopus)

  47 Downloads (Pure)