Alejandro Aguayo Orozco

Publikation

Publikationer pr. år 2016 2018 2019 2019

• 6 Tidsskriftartikel
• 1 Review

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

  Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Narayanan, D., Baig, A., Zang, J., Aguayo-Orozco, A., Carmona, R., Garcia, A. & Bach, A., 12 sep. 2019, I: Journal of Medicinal Chemistry. 62, 17, s. 8028-8052

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Proteins 100%
  • Oxidative Stress 89%
  • Surface Plasmon Resonance 86%
  • Disorder 77%
  • Polarization 67%
  28 Citationer (Scopus)

• Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

  Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stoeber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., van Thriel, C., Golka, K., Tolosa, L., Castell, J. V., Damm, G., & 28 flereSeehofer, D., Lampen, A., Braeuning, A., Buhrke, T., Behr, A-C., Oberemm, A., Gu, X., Kittana, N., van de Water, B., Kreiling, R., Fayyaz, S., van Aerts, L., Smedsrød, B., Ellinger-Ziegelbauer, H., Steger-Hartmann, T., Gundert-Remy, U., Zeigerer, A., Ullrich, A., Runge, D., Lee, S. M. L., Schiergens, T. S., Kuepfer, L., Aguayo-Orozco, A., Sachinidis, A., Edlund, K., Gardner, I., Rahnenführer, J. & Hengstler, J. G., 1 jun. 2019, I: Archives of Toxicology. 93, 6, s. 1609-1637 29 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Chemical and Drug Induced Liver Injury 100%
  • Hepatotoxic 84%
  • Peak Plasma Concentration 77%
  • Dose 58%
  • No-Observed-Adverse-Effect Level 51%
  41 Citationer (Scopus)

  6 Downloads (Pure)

• sAOP: linking chemical stressors to adverse outcomes pathway networks

  Aguayo-Orozco, A., Audouze, K., Siggaard, T., Barouki, R., Brunak, S. & Taboureau, O., 15 dec. 2019, I: Bioinformatics. 2 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Adverse Outcome Pathways 100%
  • Pathway 71%
  • Linking 63%
  • Toxicological Phenomena 29%
  • Wikis 22%
  5 Citationer (Scopus)

  4 Downloads (Pure)

• The use of systems biology in chemical risk assessment

  Aguayo-Orozco, A., Taboureau, O. & Brunak, S., 2019, I: Current Opinion in Toxicology. 15, s. 48-54 7 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Risk Assessment 100%
  • Systems Biology 98%
  • Adverse Outcome Pathways 68%
  • Toxicology 60%
  • Pharmacologic Actions 29%
  4 Citationer (Scopus)

  16 Downloads (Pure)
• 2018

  Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

  Aguayo-Orozco, A., Bois, F. Y., Brunak, S. & Taboureau, O., 2018, I: Frontiers in Genetics. 9, s. 1-15 396.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Fatty Liver 100%
  • Gene Expression 84%
  • Adverse Outcome Pathways 77%
  • linolenic acid drug combination linoleic acid 77%
  • Liver 72%
  5 Citationer (Scopus)

  101 Downloads (Pure)

• Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

  Grinberg, M., Stöber, R. M., Albrecht, W., Edlund, K., Schug, M., Godoy, P., Cadenas, C., Marchan, R., Lampen, A., Braeuning, A., Buhrke, T., Leist, M., Oberemm, A., Hellwig, B., Kamp, H., Gardner, I., Escher, S., Taboureau, O., Aguayo-Orozco, A., Sachinidis, A., & 3 flereEllinger-Ziegelbauer, H., Rahnenführer, J. & Hengstler, J. G., dec. 2018, I: Archives of Toxicology. 92, 12, s. 3517-3533 17 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Toxicogenetics 100%
  • Valproic Acid 96%
  • Directories 93%
  • Microarrays 71%
  • Hepatocytes 55%
  24 Citationer (Scopus)
• 2016

  In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects

  Orozco, A. A., Audouze, K., Brunak, S. & Taboureau, O., 1 dec. 2016, I: Current Pharmaceutical Design. 22, 46, s. 6895-6902 8 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Computer Simulation 100%
  • Therapeutic Uses 87%
  • Toxic 79%
  • Poisons 78%
  • Pharmacology 70%
  2 Citationer (Scopus)

  47 Downloads (Pure)