Tumorcelledissociering som prognostisk markør ved kolorektal cancer

Louise Klarskov, Ulla Højholt Engel, Anne Mellon Mogensen, Helle Lone Jensen, Susanne Holck, Louise Klarskov, Ulla Engel, Anne Mellon Mogensen, Helle Lone Jensen, Susanne Holck

Abstract

The invasive front of the colorectal carcinoma (CRC) in some cases displays budding, characterized by groups of up to five tumour cells. In 2006, budding was introduced in the Danish Colorectal Cancer Group's (DCCG) and the Danish Society of Pathology and Cytology's (DSPAC) CRC register form. Based on a literature survey, molecular mechanisms that may contribute to budding are reviewed, as is the mode by which this process is registered and its putative clinical significance. Despite diverse modes of budding registration, its significance as a prognostic marker has consistently been substantiated. Additionally, data on budding may prove of value in patient management.
Udgivelsesdato: 2009-Sep
Bidragets oversatte titelTumour-cell dissociation as a prognostic marker in colorectal cancer
OriginalsprogDansk
TidsskriftUgeskrift for læger
Vol/bind171
Udgave nummer39
Sider (fra-til)2812-2817
Antal sider6
ISSN0041-5782
StatusUdgivet - 2009

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