@article{1ea56a4053eb11dd8d9f000ea68e967b,
title = "Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.",
abstract = "The parB locus of plasmid R1, which mediates plasmid stability via postsegregational killing of plasmid-free cells, encodes two genes, hok and sok. The hok gene product is a potent cell-killing protein. The hok gene is regulated at the translational level by the sok gene-encoded repressor, a small anti-sense RNA complementary to the hok mRNA. The hok mRNA is extraordinarily stable, while the sok RNA decays rapidly. The mechanism of postsegregational killing is explained by the following model; the sok RNA molecule rapidly disappears in cells that have lost a parB-carrying plasmid, leading to translation of the stable hok mRNA. Consequently, the Hok protein is synthesized and killing of the plasmid-free cell follows.",
author = "K Gerdes and K Helin and Christensen, {O W} and A L{\o}bner-Olesen",
note = "Keywords: Base Sequence; Chromosome Mapping; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Molecular Sequence Data; Promoter Regions (Genetics); Protein Biosynthesis; R Factors; RNA, Bacterial; RNA, Messenger; Rifampin; Suppression, Genetic",
year = "1988",
language = "English",
volume = "203",
pages = "119--29",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "1",
}