Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development

Stoyan Petkov; Kristine Freude; Kaveh Mashayekhi-Nezamabadi; Poul Hyttel; Vanessa Hall

doi:10.1002/9781118881286.ch19

Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development

Stoyan Petkov, Kristine Freude, Kaveh Mashayekhi-Nezamabadi, Poul Hyttel, Vanessa Hall

Abstract

The lack in production of bona fide porcine pluripotent stem cells has definitely been hampered by a lack of research into porcine embryo development. Embryonic development in mammals is the extraordinary transition of a single-celled fertilized zygote into a complex fetus, which occurs in the uterus of the maternal adult during the early stages of gestation. Biomedical pig models could serve as genetic backgrounds for establishment of embryonic stem cells (ESCs) or other pluripotent stem cells (such as iPSC), which may be used to model and study diseases in vitro. This chapter provides insight into the current knowledge of pluripotent states in the developing pig embryo and the current status in establishment of bona fide porcine ESC (pESC) and piPSCs. It reflects the potential causes underlying the difficulty in establishing pluripotent stem cells and reviews recent data on global profiling of the pluripotent states in this species.

Originalsprog	Engelsk
Titel	Animal Models and Human Reproduction : Cell and Molecular Approaches with Reference to Human Reproduction
Redaktører	Heide Schatten, Gheorghe M. Constantinescu
Antal sider	24
Forlag	Wiley-Blackwell
Publikationsdato	20 mar. 2017
Sider	485-508
Kapitel	19
ISBN (Trykt)	9781118881606
ISBN (Elektronisk)	9781118881286
DOI	https://doi.org/10.1002/9781118881286.ch19
Status	Udgivet - 20 mar. 2017

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10.1002/9781118881286.ch19

Citationsformater

Petkov, S., Freude, K., Mashayekhi-Nezamabadi, K., Hyttel, P., & Hall, V. (2017). Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development. I H. Schatten, & G. M. Constantinescu (red.), Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction (s. 485-508). Wiley-Blackwell. https://doi.org/10.1002/9781118881286.ch19

Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development. / Petkov, Stoyan ; Freude, Kristine ; Mashayekhi-Nezamabadi, Kaveh et al.

Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction. red. / Heide Schatten; Gheorghe M. Constantinescu. Wiley-Blackwell, 2017. s. 485-508.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

Petkov, S , Freude, K , Mashayekhi-Nezamabadi, K , Hyttel, P & Hall, V 2017, Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development. i H Schatten & GM Constantinescu (red), Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction. Wiley-Blackwell, s. 485-508. https://doi.org/10.1002/9781118881286.ch19

Petkov S , Freude K , Mashayekhi-Nezamabadi K , Hyttel P , Hall V. Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development. I Schatten H, Constantinescu GM, red., Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction. Wiley-Blackwell. 2017. s. 485-508 doi: 10.1002/9781118881286.ch19

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Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development

Abstract

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