TY - JOUR
T1 - Therapy of haematogenous osteomyelitis
T2 - a comparative study in a porcine model and Angolan children
AU - Johansen, Louise Kruse
AU - Koch, Janne
AU - Kirketerp-Møller, Klaus
AU - Wamsler, Oswin J.
AU - Nielsen, Ole Lerberg
AU - Leifsson, Páll S.
AU - Frees, Dorte
AU - Aalbæk, Bent
AU - Jensen, Henrik Elvang
PY - 2013
Y1 - 2013
N2 - Background: It is generally accepted that surgery is necessary for the proper treatment of chronic haematogenous osteomyelitis (HO) in children. However, the correct timing of surgery and the technique most effective for debridement of infectious bone tissue is debated. Theoretically, large animal models of HO can be used for refinement and testing of surgical protocols. We report, to our knowledge for the first time, a porcine model of HO exposed to surgical treatment together with our surgical experiences with Angolan children suffering from chronic HO. Materials and Methods: Surgically-debrided bone tissue from the children and pigs were analyzed microbiologically and histopathologically together with the entire operated bones from the pigs. Results: It was illustrated that surgical intervention on porcine bones with experimentally-induced HO is representative of the handling of the condition in children. The porcine HO model can easily be used for refinement and application of surgical techniques used in order to cure children with HO.
AB - Background: It is generally accepted that surgery is necessary for the proper treatment of chronic haematogenous osteomyelitis (HO) in children. However, the correct timing of surgery and the technique most effective for debridement of infectious bone tissue is debated. Theoretically, large animal models of HO can be used for refinement and testing of surgical protocols. We report, to our knowledge for the first time, a porcine model of HO exposed to surgical treatment together with our surgical experiences with Angolan children suffering from chronic HO. Materials and Methods: Surgically-debrided bone tissue from the children and pigs were analyzed microbiologically and histopathologically together with the entire operated bones from the pigs. Results: It was illustrated that surgical intervention on porcine bones with experimentally-induced HO is representative of the handling of the condition in children. The porcine HO model can easily be used for refinement and application of surgical techniques used in order to cure children with HO.
KW - Faculty of Health and Medical Sciences
KW - Haematogenous osteomyelitis
KW - Angolan children
KW - porcine model
KW - surgical treatment
M3 - Journal article
SN - 0258-851X
VL - 27
SP - 305
EP - 312
JO - In Vivo
JF - In Vivo
IS - 3
ER -