The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania

Maria Faurholt-Jepsen; Daniel Faurholt-Jepsen; N Range; G Praygod; K Jeremiah; M G Aabye; J Changalucha; H Krarup; Dirk Lund Christensen; A B Andersen; Søren Brage; Henrik Friis

doi:10.1017/s0950268813002070

The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania

Maria Faurholt-Jepsen, Daniel Faurholt-Jepsen, N Range, G Praygod, K Jeremiah, M G Aabye, J Changalucha, H Krarup, Dirk Lund Christensen, A B Andersen, Søren Brage, Henrik Friis

3 Citationer (Scopus)

Abstract

We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-Acid glycoprotein (AGP). Sputum-positive [e^B 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (e^B 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (e^B 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.

Originalsprog	Engelsk
Tidsskrift	Epidemiology and Infection
Vol/bind	142
Udgave nummer	6
Sider (fra-til)	1334-1342
Antal sider	9
ISSN	0950-2688
DOI	https://doi.org/10.1017/s0950268813002070
Status	Udgivet - jun. 2014

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10.1017/s0950268813002070

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/BD49CA6BB066CCF370E0238F14C25CCC/S0950268813002070a.pdf/div-class-title-the-use-of-combined-heart-rate-response-and-accelerometry-to-assess-the-level-and-predictors-of-physical-activity-in-tuberculosis-patients-in-tanzania-div.pdf

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Faurholt-Jepsen, M., Faurholt-Jepsen, D., Range, N., Praygod, G., Jeremiah, K., Aabye, M. G., Changalucha, J., Krarup, H., Christensen, D. L., Andersen, A. B., Brage, S., & Friis, H. (2014). The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania. Epidemiology and Infection, 142(6), 1334-1342. https://doi.org/10.1017/s0950268813002070

The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania. / Faurholt-Jepsen, Maria; Faurholt-Jepsen, Daniel; Range, N et al.
I: Epidemiology and Infection, Bind 142, Nr. 6, 06.2014, s. 1334-1342.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Faurholt-Jepsen, M, Faurholt-Jepsen, D, Range, N, Praygod, G, Jeremiah, K, Aabye, MG, Changalucha, J, Krarup, H, Christensen, DL, Andersen, AB, Brage, S & Friis, H 2014, 'The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania', Epidemiology and Infection, bind 142, nr. 6, s. 1334-1342. https://doi.org/10.1017/s0950268813002070

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abstract = "We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-Acid glycoprotein (AGP). Sputum-positive [eB 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (eB 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (eB 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.",

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AU - Faurholt-Jepsen, Maria

AU - Faurholt-Jepsen, Daniel

AU - Range, N

AU - Praygod, G

AU - Jeremiah, K

AU - Aabye, M G

AU - Changalucha, J

AU - Krarup, H

AU - Christensen, Dirk Lund

AU - Andersen, A B

AU - Brage, Søren

AU - Friis, Henrik

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N2 - We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-Acid glycoprotein (AGP). Sputum-positive [eB 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (eB 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (eB 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.

AB - We assessed the role of tuberculosis (TB) disease and HIV infection on the level of physical activity. A combined heart rate and movement sensor was used to assess habitual physical activity in TB patients and non-TB controls. The association between sputum-negative TB, sputum-positive TB, HIV and physical activity estimates were assessed in multivariable linear regression models adjusted for age, sex, haemoglobin and alpha-1-Acid glycoprotein (AGP). Sputum-positive [eB 0·43, 95% confidence interval (CI) 0·29-0·64] and sputum-negative (eB 0·67, 95% CI 0·47-0·94) TB as well as HIV infection (eB 0·59, 95% CI 0·46-0·75) were associated with reduced activity compared to controls. Anaemia accounted for a substantial part of the effects of HIV, while elevated AGP primarily mediated the TB effect. The level of physical activity is highly influenced by TB and HIV, and mainly mediated through anaemia of infection and associated with elevated acute phase response.

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KW - Female

KW - Heart Rate

KW - Humans

KW - Male

KW - Monitoring, Physiologic

KW - Motor Activity

KW - Tanzania

KW - Tuberculosis

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ER -

The use of combined heart rate response and accelerometry to assess the level and predictors of physical activity in tuberculosis patients in Tanzania

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