The role of RecQ helicases in non-homologous end-joining

Guido Keijzers; Scott Maynard; Raghavendra A Shamanna; Lene Juel Rasmussen; Deborah L Croteau; Vilhelm A Bohr

doi:10.3109/10409238.2014.942450

The role of RecQ helicases in non-homologous end-joining

Guido Keijzers, Scott Maynard, Raghavendra A Shamanna, Lene Juel Rasmussen, Deborah L Croteau, Vilhelm A Bohr

15 Citationer (Scopus)

Abstract

DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.

Originalsprog	Engelsk
Tidsskrift	Critical Reviews in Biochemistry and Molecular Biology
Vol/bind	49
Udgave nummer	6
Sider (fra-til)	463-472
Antal sider	10
ISSN	1040-9238
DOI	https://doi.org/10.3109/10409238.2014.942450
Status	Udgivet - 1 nov. 2014

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10.3109/10409238.2014.942450

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title = "The role of RecQ helicases in non-homologous end-joining",

abstract = "DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.",

author = "Guido Keijzers and Scott Maynard and Shamanna, {Raghavendra A} and Rasmussen, {Lene Juel} and Croteau, {Deborah L} and Bohr, {Vilhelm A}",

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doi = "10.3109/10409238.2014.942450",

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T1 - The role of RecQ helicases in non-homologous end-joining

AU - Keijzers, Guido

AU - Maynard, Scott

AU - Shamanna, Raghavendra A

AU - Rasmussen, Lene Juel

AU - Croteau, Deborah L

AU - Bohr, Vilhelm A

PY - 2014/11/1

Y1 - 2014/11/1

N2 - DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.

AB - DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.

U2 - 10.3109/10409238.2014.942450

DO - 10.3109/10409238.2014.942450

M3 - Review

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SN - 1040-9238

VL - 49

SP - 463

EP - 472

JO - Critical Reviews in Biochemistry and Molecular Biology

JF - Critical Reviews in Biochemistry and Molecular Biology

IS - 6

ER -

The role of RecQ helicases in non-homologous end-joining

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