The role of mitochondrial dysfunction in the progression of Alzheimer’s disease

Claus Desler, Meryl S. Lillenes, Tone Tønjum, Lene Juel Rasmussen

14 Citationer (Scopus)

Abstract

The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.
OriginalsprogEngelsk
TidsskriftCurrent Medicinal Chemistry
Vol/bind25
Udgave nummer40
Sider (fra-til)5578 - 5587
ISSN0929-8673
DOI
StatusUdgivet - 2018

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